Sumer Undergraduate Research Program in Neuroscience of Addiction

项目摘要/摘要 此续订申请寻求在物质使用方面支持我们久负盛名的研究教育计划 精神障碍以支持本科生在医学院寻求短期暑期研究经验 南卡罗来纳大学(MUSC)。我们的目标是培养下一代独立研究人员 世卫组织可以逐步加强现有的治疗方法，并开发治疗物质使用障碍的新方法。 具体目标是：1)培养学生对这些有才华、积极进取的学生追求职业生涯的兴趣 通过提供一个有成就的研究人员的论坛，在成瘾研究领域进行生物医学研究 可以成为分享他们的热情和专业知识的导师；2)利用现有的研究培训计划， 补充和扩展学生的整体体验；3)提供一个论坛，让学生 不仅获得如何解决研究问题的基础知识，而且还学习前沿研究 技术、研究伦理和研究数据的呈现；4)有助于提高学生的整体素质 通过培养对科学本质的欣赏和获得社会科学技能和 价值；以及5)实施一项全面的评估计划，以衡量该计划被 实现其目标。每年，14名本科生将有机会进行 生物医学研究项目在主要设在本系的教师导师的指导下进行 神经科学。学生们进行的为期十周的暑期研究项目将在一个正式的 科学的陈述。其他活动包括关于集中主题的系列讲座；研究伦理 正式和非正式讨论科学素养、专业发展和 职业机会；以及社会功能。参与的教职员工构成了一个高度协作的、 以实验室为基础的跨学科研究团队。培训机会围绕以下主题进行组织 四个研究领域：可卡因复发的神经生物学基础；甲基苯丙胺的神经生物学 物质使用障碍中与性和性别有关的研究；压力和物质使用 精神错乱。该计划建立在并利用(1)南加州大学对研究的坚定和持续的承诺 培训；(2)为有才华的本科生提供有意义的研究经验的良好声誉 学生；(3)其在吸引来自代表性不足群体的学生方面取得的成绩以及 本科院校；(4)其有效的项目管理。这项R25计划将教授和推广 临床和基础科学知识的整合，强调在基础研究中获得技能 物质使用的神经生物学。

PROJECT SUMMARY/ABSTRACT This renewal application seeks support for our well-established research education program in substance use disorders to support undergraduate students pursuing short-term summer research experiences at the Medical University of South Carolina (MUSC). The goal is to develop the next generation of independent researchers who can progressively enhance existing therapies and develop novel approaches to substance use disorders. The specific aims are to: 1) Foster interest in these talented and highly motivated students to pursue careers in biomedical research in the areas of addiction research by providing a forum where accomplished investigators can be mentors sharing their enthusiasm and expertise; 2) Leverage existing research training programs at MUSC to complement and expand the overall experience of the students; 3) Provide a forum where students not only acquire the basics of how to address research problems, but also learn cutting edge research techniques, research ethics, and presentation of research data; 4) Contribute to enhancing the students' overall science literacy by nurturing an appreciation of the nature of science and acquisition of socioscientific skills and values.; and 5) Implement a comprehensive evaluation plan that measures the degree to which the program is achieving its objectives. Each year, fourteen undergraduate students will have the opportunity to conduct biomedical research projects under the guidance of faculty mentors based primarily in the Department of Neuroscience. The ten-week summer research projects conducted by the students will culminate in a formal scientific presentation. Additional activities include a lecture series on focused topics; a research ethics component; formal and informal discussions on the meaning of scientific literacy, professional development and career opportunities; and social functions. The participating faculty constitutes a highly collaborative, interdisciplinary team of laboratory-based researchers. Training opportunities are thematically organized around four areas of research: neurobiological basis of cocaine relapse; neurobiology of methamphetamine dependence; sex and gender related research in substance use disorders; and stress and substance use disorders. The program builds upon and leverages (1) MUSC's strong and continued commitment to research training; (2) its excellent reputation in providing meaningful research experiences for talented undergraduate students; (3) its record of accomplishment of attracting students from underrepresented groups and undergraduate institutions, and (4) its effective program management. This R25 program will teach and promote the integration of clinical and basic science knowledge, with an emphasis on acquiring research skills in the basic neurobiology of substance use.