Core B: Tissue Procurement and Processing

核心 B：组织采购和加工

• 批准号: 10593848
• 负责人: Bryan Copits
• 金额: $ 18.58万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593848
• 关键词: Americas; Bar Codes; Biological; Biological Factors; Biopsy; Cancer Center; Catalogs; Collaborations; Computer software; Core Facility; Data; Databases; Disease; Genetic; Human; Intercept; Knowledge; Link; Liquid substance; Medical; Medical History; Medical Records; Nerve; Nervous system structure; Neurosurgical Procedures; Organ Procurements; Orthopedic Surgery; Orthopedics; Pain; Pain Clinics; Pain Research; Pathology; Patients; Peripheral Nerves; Phenotype; Procedures; Process; Protocols documentation; Research; Research Personnel; Research Project Grants; Resources; Sampling; Secure; Services; Source; Spinal Cord; System; Tissue Preservation; Tissue Procurements; Tissue Sample; Tissues; Transplant-Related Disorder; Universities; Washington; Work; biobank; clinical diagnosis; experience; experimental study; human disease; human tissue; insight; medical schools; opioid use disorder; patient health information; pre-clinical; programs; relating to nervous system; success; tissue processing

Project Description: Tissue Procurement and Processing Core B The Tissue Processing and Procurement Core will establish a central resource to procure, process, catalog, and distribute all human tissues for the research projects in this center. This will build upon the ongoing collaborations established by investigators in the Washington University Pain Center. We will obtain human tissues from our local organ procurement organization Mid-America Transplant (DRG, spinal cord, nerve), the National Disease Research Interchange (DRG), and neurosurgical procedures (DRG, nerve) and orthopedic surgery (nerves) at Washington University School of Medicine. Dr. Bryan Copits will oversee all aspects of this core, which will use this established network of tissue sources, our validated tissue processing procedures, our knowledge of best practices for tissue preservation for all downstream applications in the research projects, and databases for handling de-identified patient medical histories. Tissues will be cataloged and linked to de-identified patient medical history using OpenSpecimen software, and transferred to the Siteman Cancer Center Tissue Procurement Core at Washington University in St Louis to take advantage of their extensive expertise in coordinating tissue storage and distribution. All investigators will have access to these tissue and medical records through OpenSpecimen to easily request samples from this Core. This Core will also coordinate with other U19 Centers in the PRECISION Human Pain Network to establish uniform protocols for human tissue procurement and processing.

项目描述：组织采购和处理核心B 组织处理和采购核心将建立一个中央资源，以采购、处理、编目和 分发本中心研究项目的所有人体组织。这将建立在正在进行的合作的基础上， 由华盛顿大学疼痛中心的研究人员建立。我们将从我们的 地方器官采购组织中美洲移植（DRG，脊髓，神经），国家疾病 研究交流（DRG），神经外科手术（DRG，神经）和整形外科手术（神经）， 华盛顿大学医学院。Bryan Copits博士将监督这个核心的各个方面， 我们建立的组织来源网络，我们经过验证的组织处理程序，我们的最佳 研究项目中所有下游应用的组织保存实践，以及 处理去身份化的病人病史将对组织进行编目，并将其链接到去识别患者 使用OpenSpecimen软件采集病史，并转移至Siteman癌症中心组织 圣刘易斯的华盛顿大学的采购中心，利用他们广泛的专业知识， 协调组织储存和分配。所有调查人员都可以接触到这些组织和医疗记录 通过OpenSpecimen轻松地从该Core请求样本。该核心还将与其他U19协调 PRECISION Human Pain Network中的中心建立统一的人体组织采购协议 和处理