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Core B: Tissue Procurement and Processing

核心 B：组织采购和加工

基本信息

批准号：
10707425
负责人：
Bryan Copits
金额：
$ 18.44万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-30 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10707425
关键词：
Bar Codes Biological Biological Factors Biopsy Body Fluids Cancer Center Catalogs Collaborations Computer software Core Facility Data Databases Disease Genetic Human Knowledge Link Medical Medical History Medical Records Nerve Nervous System Neurosurgical Procedures Organ Procurements Orthopedic Surgery Orthopedics Pain Pain Clinics Pain Research Pathology Patients Peripheral Nerves Phenotype Procedures Process Protocols documentation Research Research Personnel Research Project Grants Resources Sampling Secure Services Source Spinal Cord System Tissue Preservation Tissue Procurements Tissue Sample Tissues Transplantation Universities Washington Work biobank clinical diagnosis experience experimental study human disease human tissue insight medical schools neural neurosurgery opioid use disorder patient health information pre-clinical programs success synergism tissue processing

项目摘要

Project Description: Tissue Procurement and Processing Core B The Tissue Processing and Procurement Core will establish a central resource to procure, process, catalog, and distribute all human tissues for the research projects in this center. This will build upon the ongoing collaborations established by investigators in the Washington University Pain Center. We will obtain human tissues from our local organ procurement organization Mid-America Transplant (DRG, spinal cord, nerve), the National Disease Research Interchange (DRG), and neurosurgical procedures (DRG, nerve) and orthopedic surgery (nerves) at Washington University School of Medicine. Dr. Bryan Copits will oversee all aspects of this core, which will use this established network of tissue sources, our validated tissue processing procedures, our knowledge of best practices for tissue preservation for all downstream applications in the research projects, and databases for handling de-identified patient medical histories. Tissues will be cataloged and linked to de-identified patient medical history using OpenSpecimen software, and transferred to the Siteman Cancer Center Tissue Procurement Core at Washington University in St Louis to take advantage of their extensive expertise in coordinating tissue storage and distribution. All investigators will have access to these tissue and medical records through OpenSpecimen to easily request samples from this Core. This Core will also coordinate with other U19 Centers in the PRECISION Human Pain Network to establish uniform protocols for human tissue procurement and processing.

项目描述：组织采购与处理核心B 组织加工和采购核心将建立一个中央资源，以采购、加工、编目和为这个中心的研究项目分发所有人体组织。这将建立在正在进行的合作基础上由华盛顿大学疼痛中心的研究人员建立。我们将从我们的当地器官采购组织中美移植(DRG，脊髓，神经)，国家疾病研究交换(DRG)、神经外科手术(DRG、神经)和整形外科手术(神经) 华盛顿大学医学院。Bryan Copits博士将监督这一核心的所有方面，它将使用这个已建立的组织来源网络，我们经过验证的组织处理程序，我们对研究项目中所有下游应用的组织保存实施规程和数据库处理未确认的患者病历。组织将被编目并与身份不清的患者联系起来病史使用Openspecimen软件，并转移到Siteman癌症中心组织位于圣路易斯的华盛顿大学的采购核心，以利用他们在协调组织的储存和分配。所有调查人员都能接触到这些组织和医疗记录通过Openspecimen轻松地从此核心请求样本。该核心还将与其他U19进行协调精密人体疼痛网络中心为人体组织采购建立统一的协议和处理中。