The When to Worry about Language Study (W2W-L): Joint consideration of developmental patterning and neural substrates for enhancing earlyidentification of language impairment

何时担心语言研究 (W2W-L)：联合考虑发展模式和神经基质以增强语言障碍的早期识别

• 批准号: 10596241
• 负责人: Elizabeth Spencer Norton
• 金额: $ 7.86万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-05 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10596241
• 关键词: Accounting; Affect; Age; Agreement; Algorithms; Behavioral; Biological Markers; Brain; Characteristics; Child; Child Behavior; Classification; Clinical; Communities; Development; Distal; Early Intervention; Education; Electroencephalography; Environment; Family; Family history of; Funding; Goals; Gold; Growth; Health; Heterogeneity; Impairment; Individual; Individual Differences; Infant; Infrastructure; Intervention; Joints; Language; Language Delays; Language Development; Language Disorders; Life; Machine Learning; Measurement; Measures; Mental Health; Methods; Modeling; Neuronal Plasticity; Nursery Schools; Outcome; Parents; Pathway interactions; Pattern; Productivity; Public Health; Recording of previous events; Resources; Risk; Risk Marker; Role; Sampling; Shapes; Specific qualifier value; Standardization; Syndrome; Time; Toddler; Variant; Vocabulary; Work; base; brain behavior; cohort; design; experience; high risk; improved; individual variation; innovation; language impairment; language processing; model building; novel; predictive modeling; prevent; primary outcome; recruit; relating to nervous system; skills; social; standard measure; translational approach; visual tracking

PROJECT SUMMARY Primary language impairment (PLI) begins early in life and affects 6-8% of children. Language intervention is maximally effective the earlier it is delivered. However, normative variation in language acquisition across toddlerhood (here, 24-36 months) contributes to a high rate of false positives, impeding accurate identification of PLI prior to late preschool age. The proposed study introduces a novel, theoretically- grounded, neurodevelopmental framework designed to generate a sensitive and specific model of toddler PLI risk. Innovations introduced in this developmentally-sensitive, translational approach include: (1) a developmental precursor model using state-of-the-art methods to characterize multiple features and growth patterns of toddler emergent language patterns, within a large community sample; (2) incorporating EEG/ERP neural biomarkers of language and transactional synchrony into PLI predictive models; and (3) considering emergent mental health risk. Mental health risk is captured via multi-method measures of irritability, a developmentally meaningful marker of risk for internalizing and externalizing problems that are common correlates of PLI. The proposed When to Worry about Language Study (W2W-L) will capitalize on the team's existed funded study of 350 infants (50% irritable and 50% non irritable) (R01MH107652, Wakschlag, PI) and enrich it via recruitment of a new sub-sample of 200 late talking toddlers. This will yield a large and diverse sample of 550 24 month olds, followed to age 54 months (when PLI can be reliably evaluated). The key predictor will be toddler emergent language patterns measured via language skill, language processing, and corollary neural biomarkers. The central outcome is primary language impairment (PLI) status at preschool age, assessed via clinical gold standard measures. Key risk modifiers are distal and proximal features of the transactional language environment, and longitudinal patterns of irritability. SPECIFIC AIMS: Aim 1. Specify the contribution of language skills, processing, neural biomarkers, and their growth to early PLI prediction. Hypotheses: 1a. Language skills, processing, and neural biomarkers will each contribute incrementally to PLI prediction. 1b. Considering longitudinal patterns will enhance prediction. Aim 2. Identify the distal risk- and proximal protective- features of the transactional language environment that provide greatest explanatory power for individual differences in PLI. Hypothesis 2: Family history and poor parental language ability will increase PLI risk, and features of parental input, and behavioral and neural synchrony will decrease PLI risk. Aim 3. Examine the mutual influences of toddler irritability, proximal language environment, and emergent language patterns on PLI pathways. Hypothesis 3: A model specifying these reciprocal influences over time will sharpen PLI prediction beyond variance explained by their individual influences. Aim 4. Evaluate feasibility of a clinical algorithm for earlier PLI risk identification. We will use machine learning approaches to generate a sensitive/specific, feasible clinical model building on Aims 1-3.

项目摘要 初级语言障碍（PLI）在生命的早期开始，影响了6-8％的儿童。语言干预 最大效率是越早提供的。但是，语言习得的规范性差异 幼儿（在这里，24-36个月）有助于高阳性率，阻碍了准确的识别 幼儿园晚期之前的PLI。拟议的研究介绍了一项新颖的，理论上的基础 神经发育框架旨在生成幼儿PLI的敏感和特定模型 风险。这种对发展敏感的，翻译方法中引入的创新包括：（1） 使用最先进的方法来表征多个特征和增长的发展前体模型 大型社区样本中的幼儿新兴语言模式的模式； （2）合并EEG/ERP 语言和交易同步的神经生物标志物成PLI预测模型； （3）考虑 紧急的心理健康风险。心理健康风险是通过烦躁的多方法来捕获的 具有内在化和外在化问题的风险有意义的标志，这是常见的 PLI的相关性。何时担心语言研究的提议（W2W-L）将利用 团队的350名婴儿的资助研究（50％易怒和50％rirdibal）（R01MH107652，Wakschlag， PI）并通过招募200个较晚幼儿的新子样本来丰富它。这将产生一个大的 550个24个月大的样本随后到54个月（可以可靠地评估PLI）。这 关键预测指标将是通过语言技能，语言处理测量的幼儿新兴语言模式， 和推论神经生物标志物。核心结果是主要语言障碍（PLI）状态 通过临床黄金标准措施评估的学龄前年龄。关键风险修饰符是远端和近端 交易语言环境的特征和纵向模式。 具体目的：目标1。指定语言技能，处理，神经生物标志物和 它们的增长到早期PLI预测。假设：1a。语言技能，处理和神经生物标志物将 每个都会逐步贡献PLI预测。 1B。考虑纵向模式将增强预测。 目标2。确定交易语言环境的远端风险和近端保护特征 为PLI的个体差异提供最大的解释能力。假设2：家族史和贫穷 父母的语言能力将增加PLI风险和父母输入的特征以及行为和神经 同步将降低PLI风险。目标3。检查幼儿烦躁，近端语言的相互影响 环境和PLI途径上的新兴语言模式。假设3：指定这些的模型 随着时间的推移，相互影响的影响将使PLI预测超出其个人所解释的差异 影响。目标4。评估临床算法对早期PLI风险识别的可行性。我们将使用 机器学习方法以产生目标1-3的敏感/特异性，可行的临床模型。

项目成果

Understanding event-related potentials (ERPs) in clinical and basic language and communication disorders research: a tutorial.

• DOI: 10.1111/1460-6984.12535
• 发表时间: 2020-07
• 期刊: International journal of language & communication disorders
• 影响因子: 2.4
• 作者: McWeeny S;Norton ES
• 通讯作者: Norton ES

Social EEG: A novel neurodevelopmental approach to studying brain-behavior links and brain-to-brain synchrony during naturalistic toddler-parent interactions.

• DOI: 10.1002/dev.22240
• 发表时间: 2022-03
• 期刊: DEVELOPMENTAL PSYCHOBIOLOGY
• 影响因子: 2.2
• 作者: Norton, Elizabeth S.;Manning, Brittany L.;Harriott, Emily M.;Nikolaeva, Julia, I;Nyabingi, Olufemi Shakuur;Fredian, Kaitlyn M.;Page, Jessica M.;McWeeny, Sean;Krogh-Jespersen, Sheila;MacNeill, Leigha A.;Roberts, Megan Y.;Wakschlag, Lauren S.
• 通讯作者: Wakschlag, Lauren S.

Disruption Leads to Methodological and Analytic Innovation in Developmental Sciences: Recommendations for Remote Administration and Dealing With Messy Data.

• DOI: 10.3389/fpsyg.2021.732312
• 发表时间: 2021
• 期刊: Frontiers in psychology
• 影响因子: 3.8
• 作者: Krogh-Jespersen S;MacNeill LA;Anderson EL;Stroup HE;Harriott EM;Gut E;Blum A;Fareedi E;Fredian KM;Wert SL;Wakschlag LS;Norton ES
• 通讯作者: Norton ES

Nonrapid eye movement sleep characteristics and relations with motor, memory, and cognitive ability from infancy to preadolescence.

• DOI: 10.1002/dev.22202
• 发表时间: 2021-12
• 期刊: Developmental psychobiology
• 影响因子: 2.2
• 作者: Page JM;Wakschlag LS;Norton ES
• 通讯作者: Norton ES

Using Animated Action Scenes to Remotely Assess Sentence Diversity in Toddlers.

• DOI: 10.1097/tld.0000000000000280
• 发表时间: 2022-04
• 期刊: TOPICS IN LANGUAGE DISORDERS
• 影响因子: 1.4
• 作者: Krok, Windi;Norton, Elizabeth S.;Buchheit, Mary Kate;Harriott, Emily M.;Wakschlag, Lauren;Hadley, Pamela A.
• 通讯作者: Hadley, Pamela A.