Cancer Animal Models

癌症动物模型

• 批准号: 10595759
• 负责人: Melissa GILBERT-ROSS
• 金额: $ 10.27万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-07 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10595759
• 关键词: 3-Dimensional; Animal Cancer Model; Animal Model; Animals; Applications Grants; Award; Brain Neoplasms; Cancer Center Support Grant; Cancer Control; Categories; Cell Line; Cells; Cellular biology; Collaborations; Colon Carcinoma; Cost Savings; Custom; Development; Developmental Therapeutics Program; Drug Delivery Systems; Ensure; Epigenetic Process; Equipment; Fostering; Funding; Future; Genetic; Genetically Engineered Mouse; Goals; Health; Image; Imaging Techniques; Imaging technology; Immunocompetent; Immunotherapy; In Vitro; Individual; Institutes; Label; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Malignant neoplasm of prostate; Measurement; Measures; Modeling; Monitor; Multimodal Imaging; Mus; Neoplasm Metastasis; Operative Surgical Procedures; Patients; Phenotype; Play; Publications; Reproducibility; Research; Research Personnel; Resolution; Resource Sharing; Resources; Role; Service delivery model; Services; Signal Transduction; Source; Techniques; Technology; Testing; Therapeutic; Therapeutic Clinical Trial; Time; Training Support; Translating; Translations; Universities; Xenograft Model; anticancer research; base; bioluminescence imaging; cancer cell; cancer genetics; cancer prevention; cellular imaging; clinical optical imaging; clinical translation; cost effective; fluorescence imaging; gene induction; imaging system; in vivo; in vivo imaging; in vivo imaging system; malignant breast neoplasm; member; mouse model; multimodality; multiphoton microscopy; pre-clinical; programs; screening; tomography; translational potential; treatment response; tumor; tumor growth; tumor xenograft

CANCER ANIMAL MODELS SHARED RESOURCE PROJECT SUMMARY/ ABSTRACT The Cancer Animal Models Shared Resource (Mouse SR; Categories 1.02, 1.04, 1.06) of Winship Cancer Institute of Emory University (Winship) was established in 2012 to promote cancer discovery by providing expertise to Winship investigators in the development and analysis of animal models of cancer, with a particular focus on genetically engineered mouse models (GEMMs). Since its inception, Mouse SR has supported investigators across all four Winship programs (Cancer Genetics and Epigenetics (CGE), Cancer Cell Biology (CCB), Discovery and Developmental Therapeutics (DDT), and Cancer Prevention and Control (CPC)) with genetic mouse models of colon, prostate, breast, pancreatic, and lung cancer and brain tumors. The number of Winship members actively using Mouse SR increased during the current funding period from seven to twenty- one individual investigators. In 2014, Winship appointed a new Mouse SR Director and added an additional full- time staff member. Mouse SR has expanded its services to include cell-line and patient-derived orthotopic xenograft models and has acquired an IVIS Spectrum pre-clinical optical imaging system. The IVIS Spectrum is capable of detecting high-resolution bioluminescent and fluorescent sources deep within the animal and allows for longitudinal monitoring of therapeutic responses in vivo. Mouse SR provides a significant cost savings to Winship investigators by offering a source of centralized expertise and equipment. Future goals of Mouse SR include establishing immune-competent syngeneic models to support testing of immunotherapies and to establish a bank of GEMM-derived cells lines for rapid in vitro compound screening prior to in vivo studies. During the current funding period, Mouse SR has supported multiple grant applications and awards, contributed to high- impact publications, and supported the successful submission for two new multi-PI R01s and a U01 award. To further support Winship's programmatic initiatives, Mouse SR proposes to: 1) support outstanding cancer research by providing access to high quality services and technologies that promote scientific collaboration and translational potential and 2) provide the outstanding in vivo imaging technologies and associated expertise in support of pre-clinical animal model research.

共享资源的肿瘤动物模型 项目摘要/摘要 Winship癌症动物模型共享资源(小鼠SR；1.02、1.04、1.06类) 埃默里大学(Winship)研究所成立于2012年，旨在通过提供 Winship研究人员在开发和分析癌症动物模型方面的专业知识，特别是 关注转基因小鼠模型(GEMM)。自成立以来，Mouse SR一直支持 所有四个Winship项目(癌症遗传学和表观遗传学(CGE)、癌细胞生物学)的研究人员 (CCB)、发现和开发治疗(DDT)和癌症预防和控制(CPC))与 结肠癌、前列腺癌、乳腺癌、胰腺癌、肺癌和脑瘤的小鼠遗传模型。数量 积极使用Mouse SR的Winship成员在当前资助期内从7个增加到20个- 一名个人调查员。2014年，Winship任命了一位新的Mouse SR总监，并增加了一名额外的完整- 时代周刊工作人员。MICE SR已经将其服务扩展到包括细胞系和患者来源的原位移植 异种移植模型，并已获得IVIS Spectrum临床前光学成像系统。IVIS频谱是 能够探测动物体内的高分辨率生物发光和荧光源，并允许 用于体内治疗反应的纵向监测。MICE SR可显著节省成本 Winship调查人员通过提供集中的专业知识和设备来源。小鼠SR的未来目标 包括建立具有免疫能力同基因模型，以支持免疫疗法的测试并 建立GEMM来源的细胞库，用于在体内研究之前快速进行体外化合物筛选。在.期间 在当前的资助期内，Mouse SR支持了多项赠款申请和奖励，为 支持成功提交两个新的多圆周率R01和一个U01奖。至 进一步支持Winship的计划倡议，Mouse SR建议：1)支持未解决的癌症 通过提供高质量的服务和技术来促进科学合作和研究 翻译潜力和2)提供出色的活体成像技术和相关专业知识 支持临床前动物模型研究。