Cancer Animal Models

癌症动物模型

• 批准号: 9905358
• 负责人: Melissa GILBERT-ROSS
• 金额: $ 10.08万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9905358
• 关键词: 3-Dimensional; Animal Cancer Model; Animal Model; Animals; Applications Grants; Award; Brain Neoplasms; Cancer Center Support Grant; Cancer Control; Categories; Cell Line; Cells; Cellular biology; Collaborations; Colon Carcinoma; Cost Savings; Custom; Development; Developmental Therapeutics Program; Drug Delivery Systems; Ensure; Epigenetic Process; Equipment; Fostering; Funding; Future; Genetic; Genetically Engineered Mouse; Goals; Health; Image; Imaging Techniques; Imaging technology; Immunocompetent; Immunotherapy; In Vitro; Individual; Institutes; Label; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Malignant neoplasm of prostate; Measurement; Measures; Modeling; Monitor; Multimodal Imaging; Mus; Neoplasm Metastasis; Operative Surgical Procedures; Patients; Phenotype; Play; Publications; Reproducibility; Research; Research Personnel; Resolution; Resource Sharing; Resources; Role; Service delivery model; Services; Signal Transduction; Source; Techniques; Technology; Testing; Therapeutic; Therapeutic Clinical Trial; Time; Training Support; Translating; Translations; Universities; Xenograft Model; anticancer research; base; cancer cell; cancer genetics; cancer prevention; cellular imaging; clinical optical imaging; clinical translation; cost effective; fluorescence imaging; gene induction; imaging system; in vivo; in vivo imaging; in vivo imaging system; malignant breast neoplasm; member; mouse model; multimodality; multiphoton microscopy; pre-clinical; programs; screening; tomography; treatment response; tumor; tumor growth; tumor xenograft

CANCER ANIMAL MODELS SHARED RESOURCE PROJECT SUMMARY/ ABSTRACT The Cancer Animal Models Shared Resource (Mouse SR; Categories 1.02, 1.04, 1.06) of Winship Cancer Institute of Emory University (Winship) was established in 2012 to promote cancer discovery by providing expertise to Winship investigators in the development and analysis of animal models of cancer, with a particular focus on genetically engineered mouse models (GEMMs). Since its inception, Mouse SR has supported investigators across all four Winship programs (Cancer Genetics and Epigenetics (CGE), Cancer Cell Biology (CCB), Discovery and Developmental Therapeutics (DDT), and Cancer Prevention and Control (CPC)) with genetic mouse models of colon, prostate, breast, pancreatic, and lung cancer and brain tumors. The number of Winship members actively using Mouse SR increased during the current funding period from seven to twenty- one individual investigators. In 2014, Winship appointed a new Mouse SR Director and added an additional full- time staff member. Mouse SR has expanded its services to include cell-line and patient-derived orthotopic xenograft models and has acquired an IVIS Spectrum pre-clinical optical imaging system. The IVIS Spectrum is capable of detecting high-resolution bioluminescent and fluorescent sources deep within the animal and allows for longitudinal monitoring of therapeutic responses in vivo. Mouse SR provides a significant cost savings to Winship investigators by offering a source of centralized expertise and equipment. Future goals of Mouse SR include establishing immune-competent syngeneic models to support testing of immunotherapies and to establish a bank of GEMM-derived cells lines for rapid in vitro compound screening prior to in vivo studies. During the current funding period, Mouse SR has supported multiple grant applications and awards, contributed to high- impact publications, and supported the successful submission for two new multi-PI R01s and a U01 award. To further support Winship's programmatic initiatives, Mouse SR proposes to: 1) support outstanding cancer research by providing access to high quality services and technologies that promote scientific collaboration and translational potential and 2) provide the outstanding in vivo imaging technologies and associated expertise in support of pre-clinical animal model research.

癌症动物模型共享资源 项目总结/摘要 Winship Cancer的癌症动物模型共享资源（小鼠SR;类别1.02，1.04，1.06） 埃默里大学研究所（Winship）成立于2012年，旨在通过提供 在癌症动物模型的开发和分析方面， 基因工程小鼠模型（GEMM）自成立以来，Mouse SR一直支持 所有四个Winship项目的研究人员（癌症遗传学和表观遗传学（CGE），癌症细胞生物学 (CCB)、发现和发展治疗学（DDT）和癌症预防和控制（CPC））， 结肠癌、前列腺癌、乳腺癌、胰腺癌和肺癌以及脑肿瘤的遗传小鼠模型。的数量 在当前的资助期内，积极使用Mouse SR的Winship成员从7人增加到20人， 一个独立的调查员。2014年，Winship任命了一位新的鼠标SR总监，并增加了一个额外的全职员工， 时间工作人员。Mouse SR已将其服务扩展到包括细胞系和患者源性原位 该公司已经建立了异种移植模型，并获得了IVIS光谱临床前光学成像系统。IVIS光谱是 能够检测动物体内深处的高分辨率生物发光和荧光源， 用于体内治疗反应的纵向监测。鼠标SR可显著节省成本， 通过提供集中的专业知识和设备来赢得调查人员的信任。Mouse SR的未来目标 包括建立具有免疫能力的同基因模型以支持免疫疗法的测试， 在体内研究之前建立用于快速体外化合物筛选的GEMM衍生细胞系库。期间 在当前的资助期内，Mouse SR支持了多个赠款申请和奖项，为高 影响出版物，并支持成功提交两个新的多PI R 01和U 01奖。到 为了进一步支持Winship的计划性举措，Mouse SR建议：1）支持杰出的癌症 通过提供高质量的服务和技术，促进科学合作， 翻译潜力和2）提供杰出的体内成像技术和相关的专业知识， 支持临床前动物模型研究。