Emory Integrated Genomics Core

埃默里综合基因组学核心

• 批准号: 10595761
• 负责人: Christopher D Scharer
• 金额: $ 15.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-07 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10595761
• 关键词: Adopted; Adoption; Bioinformatics Shared Resource; Biological Assay; Biometry; Cancer Center Support Grant; Cancer Diagnostics; Categories; Cells; Clinical; Clinical Laboratory Improvement Amendments; Clinical Trials; Cloning; Collaborations; Custom; DNA; Data; Diagnostic tests; Doctor of Philosophy; Ensure; Environment; Experimental Designs; Funding; Gene Expression; Genetic; Genomics; Genomics Shared Resource; Goals; Improve Access; Individual; Institutes; Laboratories; Licensing; Malignant Neoplasms; Mission; Modeling; Mutation; Nucleic Acids; Organizational Efficiency; Positioning Attribute; Price; Protocols documentation; Research; Research Design; Research Personnel; Research Support; Resource Sharing; SNP genotyping; Scientist; Services; Technology; Time; Tissue Sample; Universities; Vendor; Work; anticancer research; cancer genomics; computing resources; cost; density; experimental study; functional genomics; genomic data; genomic platform; member; methylation pattern; microbiome; next generation sequencing; novel; sequencing platform; tumor

EMORY INTEGRATED GENOMICS SHARED RESOURCE PROJECT SUMMARY/ ABSTRACT The Emory Integrated Genomics Core Shared Resource (Genomics SR; Categories 1.16, 1.21, and 1.35) provides services allowing scientists to conduct deep genomic sequencing, probe gene expression and methylation patterns in a tissue sample, or search for mutations in an individual's DNA or in a tumor. The central mission of this facility as a Winship shared resource is to support the research efforts of Winship members by providing exceptional cancer genomics services Genomics SR provides services in research and CLIA settings which include nucleic acid extraction, Illumina sequencing, high-density microarray services on both the Affymetrix and Illumina platforms, targeted enrichment, and single nucleotide polymorphism (SNP) genotyping. Significant improvements in shared resource organization and efficiency have increased capacity, lowered costs, and increased service offerings. Service offerings for Illumina next generation sequencing (NGS) have dramatically increased after the adoption of a broker model in which all large-scale service requests are competitively outsourced to one of several academic or commercial vendors. New services, including microbiome and single cell services, have been launched for Winship members. Genomics SR has maintained its CLIA license (CLIA: 11D1086150) and developed closer ties with the Emory Genetics Laboratory, which is now offering clinical cancer diagnostic testing. Improved access to computational resources through the Emory Integrated Computational Core (EICC) and increased collaboration with Winship’s Biostatistics and Bioinformatics Shared Resource (BBISR) have significantly enhanced the analysis of large-scale genomics data sets by Winship members. As a consequence of these changes, usage by Winship members have significantly increased during the current funding period. Genomics SR currently provides valuable services in support of Winship discovery and is well positioned to adopt novel genomic services which will advance Winship research.

Emory集成基因组学共享资源 项目摘要/摘要 Emory集成基因组学核心共享资源(基因组学SR；类别1.16、1.21和1.35) 提供服务，允许科学家进行深入的基因组测序，探测基因表达和 组织样本中的甲基化模式，或搜索个人DNA或肿瘤中的突变。中环 该设施作为Winship共享资源的使命是通过以下方式支持Winship成员的研究工作 提供卓越的癌症基因组学服务基因组学SR在研究和CLIA环境中提供服务 其中包括核酸提取、光照测序、高密度微阵列服务 Affymetrix和Illumina平台、靶向浓缩和单核苷酸多态(SNP)基因分型。 在共享资源组织和效率方面的重大改进增加了容量，降低了成本， 和更多的服务提供。Illumina下一代测序(NGS)服务产品包括 在采用代理模型后显著增加，在该模型中，所有大规模服务请求 竞争性地外包给几家学术或商业供应商之一。新服务，包括 微生物群和单细胞服务已经为Winship成员推出。基因组学SR坚持认为 它的CLIA许可证(CLIA：11D1086150)，并与埃默里遗传实验室建立了更紧密的联系，后者是 现在提供临床癌症诊断测试。通过Emory改进对计算资源的访问 集成计算核心(EICC)并加强与Winship的生物统计和 生物信息学共享资源(BBISR)显著提高了大规模基因组数据的分析能力 由Winship成员提供的套装。由于这些变化，Winship成员的使用量显著增加 在本供资期间增加了。基因组学SR目前提供有价值的服务，以支持 Winship发现，并处于有利地位，采用新的基因组服务，将推动Winship的研究。