Kansas Center for Metabolism and Obesity REsearch (KC-MORE) - Cells, Tissues, Bioanalysis and Biostatistics Core

堪萨斯代谢和肥胖研究中心 (KC-MORE) - 细胞、组织、生物分析和生物统计学核心

• 批准号: 10598036
• 负责人: Udayan Apte
• 金额: $ 29.71万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598036
• 关键词: Address; Adipose tissue; Animal Experiments; Animal Model; Arkansas; Award; Basic Science; Big Data; Bioinformatics; Biological Assay; Biomedical Research; Biometry; Biostatistics Core; Blood; Cell Culture Techniques; Cells; Cellular Structures; Centers of Research Excellence; Charge; Clinical; Collaborations; Communities; Computing Methodologies; Confusion; Core Facility; Custom; Data Collection; Data Set; Dedications; Development; Disease; Experimental Models; Face; Flow Cytometry; Funding; Genomics; Goals; Grant; Human; In Vitro; Infrastructure; Institution; Institutional Review Boards; Investigation; Kansas; Liver; Logistics; Medical; Medical center; Metabolic; Metabolic Diseases; Metabolism; Methodology; Methods; Muscle; Nuts; Obesity; Obesity associated disease; Organ; Pathogenesis; Patients; Plasma; Process; Proteomics; Research; Research Personnel; Research Project Grants; Research Training; Resources; Rodent; Sampling; Science; Scientist; Serum; Services; Technical Expertise; Techniques; Technology; Testing; Tissue Banks; Tissue Sample; Tissues; Training; Translational Research; United States National Institutes of Health; Universities; biobank; design; disease mechanisms study; energy balance; high throughput screening; metabolomics; multidimensional data; patient population; population based; precision medicine; skills; transcriptomics; translational pipeline

CELLS, TISSUES, BIOANALYSIS AND BIOSTATISTICS CORE: PROJECT SUMMARY Adding a translational component to confirm ideas generated using in vitro and animal models is a vital part of biomedical research. This is especially critical for a multi-organ disease like obesity. The most common path followed by basic scientists is to obtain human samples and perform bioanalytical tests confirming their findings obtained from experimental models. But this is easier said than done. Researchers face many challenges in bridging this translational gap including confusing regulatory paperwork, lack of willing clinical collaborators, lack of infrastructure to obtain and store patient samples, and much more. The Cells, Tissues, Bioanalysis and Biostatistics (CTBB) core is designed to address this very issue. The CTBB core will be a “soup to nuts” solution where the entire pipeline of translational research will be made efficient and easy to use for basic science researchers who are part of Kansas Center for Metabolism and Obesity REsearch (KC-MORE) and beyond. The CTBB core has three components. The first is the Cells and Tissues Biorepository, which will develop collaborations with clinicians willing to collect samples after obtaining necessary IRB permissions, and collect, store, and dispense clinical samples to basic scientists, supported by clinical coordinator. The second component is Bioanalytical services, where a trained research technician will be available to provide technical help to develop and perform specific bioanalytical assays. Further, we will function as liaisons between several existing institutional and regional NIH-funded core facilities and the COBRE investigators. These include Genomics core and Flow Cytometry core facilities at the University of Kansas Medical Center (KUMC) and IDEA National Resource for Quantitative Proteomics at University of Arkansas for Medical Sciences. The third component of the CTBB core is focused on biostatistics and bioinformatics expertise. For this, the CTBB core will collaborate with the Quantitative Omics core, which is part of Kansas Institute for Precision Medicine COBRE at KUMC. The CTBB core will partly support additional statisticians which will provide biostatistics and bioinformatics expertise to KC-MORE researchers. Taken together, the CTBB core will generate an efficient, comprehensive translational research pipeline, which will provide one stop solution for basic scientists to achieve translational research goals.

细胞、组织、生物分析和生物统计学核心：项目摘要 添加翻译成分以确认使用体外和动物模型产生的想法是 生物医学研究。这对于像肥胖这样的多器官疾病尤其关键。最常见的路径 基础科学家紧随其后的是获取人体样本并进行生物分析测试以证实他们的发现 从实验模型中获得。但这说起来容易做起来难。研究人员面临着许多挑战 弥合这一翻译差距，包括令人困惑的监管文书工作，缺乏自愿的临床合作者，缺乏 用于获取和存储患者样本的基础设施，以及更多。细胞、组织、生物分析和 生物统计(CTBB)核心就是为解决这一问题而设计的。CTBB核心将是一个“从汤到坚果”的解决方案 在那里，整个转化研究管道将变得高效和易于用于基础科学 堪萨斯新陈代谢和肥胖研究中心(KC-MORE)及以后的研究人员。 CTBB核心有三个组成部分。第一个是细胞和组织生物库，它将发展 与愿意在获得必要的IRB许可后收集样本的临床医生合作，并收集 在临床协调员的支持下，储存和分发临床样本给基础科学家。第二个组成部分 是生物分析服务，将有训练有素的研究技术人员提供技术帮助，以开发 并进行特定的生物分析测试。此外，我们将作为几个现有的 机构和区域NIH资助的核心设施和科布雷调查人员。其中包括基因组学核心 和位于堪萨斯大学医学中心(KUMC)和IDEA National的流式细胞术核心设施 阿肯色大学医学科学定量蛋白质组学资源。的第三个组成部分 CTBB的核心侧重于生物统计和生物信息学的专门知识。为此，CTBB核心将合作 与Quantity Omics核心，这是堪萨斯精密医学科布雷在KUMC的一部分。这个 CTBB核心将部分支持额外的统计员，他们将提供生物统计和生物信息学方面的专门知识 致KC-更多的研究人员。综上所述，CTBB核心将产生高效、全面的翻译 研究流水线，将为基础科学家实现翻译研究目标提供一站式解决方案。