Children's National Hospital Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)

国家儿童医院基地联盟 - HIV/艾滋病干预青少年医学试验网络 (ATN) 运营和合作中心(UM2 临床试验可选)

基本信息

  • 批准号:
    10599559
  • 负责人:
  • 金额:
    $ 33.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-22 至 2029-06-30
  • 项目状态:
    未结题

项目摘要

ABSTRACT Children's National Hospital (CNH) CRS Despite the substantial progress in the HIV epidemic, adolescents, and young adults (AYA) aged 13-24 years living with HIV have worse health outcomes compared to any other age groups in the United States (US). Children's National Hospital (CNH), provides comprehensive HIV prevention and treatment services to the majority of AYA from the District of Columbia (DC) eligible metropolitan area (EMA) including three national HIV epidemic hotspots—Washington, DC, and two Maryland counties (Montgomery and Prince George's). Within DC, which continues to have the highest rates of new HIV infection in the United States, AYA have a high HIV prevalence of 0.3%, and high incidence of sexually transmitted infections, placing them at substantial risk for acquiring HIV. Through universal HIV counselling and opt-out screening, CNH reaches out to thousands of AYA in the DC EMA yearly with HIV prevention and testing services. Currently ~300 primarily minority Black AYA are in care at CNH for pre-exposure prophylaxis and antiretroviral treatment. CNH has a longstanding history of collaboration within local, regional, and national scientific networks, including prior participation in the Adolescent Trials Network (ATN). CNH has served as a successful recruitment site to multiple industry-sponsored investigational new drug clinical trials and received an uninterrupted line of DC Department of Health funding for HIV prevention and testing for more than 10 years. CNH has well-established partnerships with local and regional community-based organizations and a strong track-record of leadership in AYA HIV research within the broader local community of academic and community-based investigators, including its active role in DC Center for AIDS Research and DC Cohort Study. The overarching goal of the proposed ATN CNH consortium site is to contribute to the Westat-led ATN Operation and Collaboration Center (OCC) long-term scientific impact while expanding its role in delivering direct public health impacts on the local, regional, and national HIV epidemic among AYA. To achieve this goal, CNH will: (a) actively participate in the development and implementation of the Westat-led ATN OCC clinical trials identified by the ATN Executive and Scientific Leadership Committees; (b) deliver innovative solutions to optimize recruitment, enrollment, and retention of AYA at multiple sites in the DC EMA in ATN studies and ensure local laboratory capacity and pharmacy support; (c) propose novel concepts, approaches, and methodologies in implementation and clinical science, and development and optimization of biomedical prevention and treatment tools for AYA; and (d) meaningfully contribute to the Westat-led ATN OCC leadership model through sustained CNH site and AYA community engagement, expanding network collaborations through established regional collaborations among clinical, academic, community-based AYA focused partners, local DOHs, and schools. By participating in the Westat-led ATN OCC, CNH is uniquely positioned to contribute to advancing the National HIV/AIDS Strategy and the national plan of Ending the HIV Epidemic in the United States.
国家儿童医院(CNH) CRS

项目成果

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Natella Yurievna Rakhmanina其他文献

Natella Yurievna Rakhmanina的其他文献

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{{ truncateString('Natella Yurievna Rakhmanina', 18)}}的其他基金

Children's National Hospital Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)
国家儿童医院站点联盟 - HIV/艾滋病干预青少年医学试验网络 (ATN) 运营和合作中心(UM2 临床试验可选)
  • 批准号:
    10709605
  • 财政年份:
    2022
  • 资助金额:
    $ 33.5万
  • 项目类别:
Effect of Puberty on the Phamacokinetics of Efavirenz in HIV-infected Children
青春期对 HIV 感染儿童依非韦伦药代动力学的影响
  • 批准号:
    7687034
  • 财政年份:
    2009
  • 资助金额:
    $ 33.5万
  • 项目类别:
Effect of Puberty on the Phamacokinetics of Efavirenz in HIV-infected Children
青春期对 HIV 感染儿童依非韦伦药代动力学的影响
  • 批准号:
    8099653
  • 财政年份:
    2009
  • 资助金额:
    $ 33.5万
  • 项目类别:
Effect of Puberty on the Phamacokinetics of Efavirenz in HIV-infected Children
青春期对 HIV 感染儿童依非韦伦药代动力学的影响
  • 批准号:
    8306188
  • 财政年份:
    2009
  • 资助金额:
    $ 33.5万
  • 项目类别:
Effect of Puberty on the Phamacokinetics of Efavirenz in HIV-infected Children
青春期对 HIV 感染儿童依非韦伦药代动力学的影响
  • 批准号:
    7891190
  • 财政年份:
    2009
  • 资助金额:
    $ 33.5万
  • 项目类别:
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