Children's National Hospital Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)

国家儿童医院基地联盟 - HIV/艾滋病干预青少年医学试验网络 (ATN) 运营和合作中心（UM2 临床试验可选）

• 批准号: 10599559
• 负责人: Natella Yurievna Rakhmanina
• 金额: $ 33.5万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10599559
• 关键词: AIDS prevention; AIDS/HIV problem; Academy; Acquired Immunodeficiency Syndrome; Adolescent; Adolescent Medicine Trials Network; Adolescent and Young Adult; Adult; American; Area; Assessment tool; Behavioral Sciences; Black race; Capital; Caring; Child; Childhood; Chlamydia; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Cohort Studies; Collaborations; Communities; Counseling; County; Data; Development; District of Columbia; Enrollment; Ensure; Epidemic; European; Funding; Goals; Gonorrhea; Guidelines; HIV; HIV Infections; HIV diagnosis; HIV prevention trial; HIV-infected adolescents; Health; Health Services Accessibility; Hospitals; Hotlines; Human immunodeficiency virus test; Incidence; Industry; Infection; International Maternal Pediatric Adolescent AIDS Clinical Trials; Intervention; Intervention Studies; Investigational Drugs; Laboratories; Leadership; Maryland; Methodology; Minority; Modeling; National Children' s Study; Outcome; Participant; Pediatric HIV/AIDS Cohort Study; Pediatrics; Pharmacy facility; Physicians; Positioning Attribute; Prevalence; Prevention; Productivity; Psychosocial Assessment and Care; Public Health; Publishing; Readiness; Recording of previous events; Research; Research Personnel; Risk; Role; Schools; Sexually Transmitted Diseases; Site; Social Sciences; Teletherapy; United States; United States Dept. of Health and Human Services; United States National Institutes of Health; Washington; age group; aged; antiretroviral therapy; base; care systems; clinical center; community engagement; cooking; high school; implementation science; innovation; metropolitan; novel; operation; pediatric human immunodeficiency virus; peer support; pre-exposure prophylaxis; prevent; prevention service; programs; recruit; screening; testing services; tool; treatment services

ABSTRACT Children's National Hospital (CNH) CRS Despite the substantial progress in the HIV epidemic, adolescents, and young adults (AYA) aged 13-24 years living with HIV have worse health outcomes compared to any other age groups in the United States (US). Children's National Hospital (CNH), provides comprehensive HIV prevention and treatment services to the majority of AYA from the District of Columbia (DC) eligible metropolitan area (EMA) including three national HIV epidemic hotspots—Washington, DC, and two Maryland counties (Montgomery and Prince George's). Within DC, which continues to have the highest rates of new HIV infection in the United States, AYA have a high HIV prevalence of 0.3%, and high incidence of sexually transmitted infections, placing them at substantial risk for acquiring HIV. Through universal HIV counselling and opt-out screening, CNH reaches out to thousands of AYA in the DC EMA yearly with HIV prevention and testing services. Currently ~300 primarily minority Black AYA are in care at CNH for pre-exposure prophylaxis and antiretroviral treatment. CNH has a longstanding history of collaboration within local, regional, and national scientific networks, including prior participation in the Adolescent Trials Network (ATN). CNH has served as a successful recruitment site to multiple industry-sponsored investigational new drug clinical trials and received an uninterrupted line of DC Department of Health funding for HIV prevention and testing for more than 10 years. CNH has well-established partnerships with local and regional community-based organizations and a strong track-record of leadership in AYA HIV research within the broader local community of academic and community-based investigators, including its active role in DC Center for AIDS Research and DC Cohort Study. The overarching goal of the proposed ATN CNH consortium site is to contribute to the Westat-led ATN Operation and Collaboration Center (OCC) long-term scientific impact while expanding its role in delivering direct public health impacts on the local, regional, and national HIV epidemic among AYA. To achieve this goal, CNH will: (a) actively participate in the development and implementation of the Westat-led ATN OCC clinical trials identified by the ATN Executive and Scientific Leadership Committees; (b) deliver innovative solutions to optimize recruitment, enrollment, and retention of AYA at multiple sites in the DC EMA in ATN studies and ensure local laboratory capacity and pharmacy support; (c) propose novel concepts, approaches, and methodologies in implementation and clinical science, and development and optimization of biomedical prevention and treatment tools for AYA; and (d) meaningfully contribute to the Westat-led ATN OCC leadership model through sustained CNH site and AYA community engagement, expanding network collaborations through established regional collaborations among clinical, academic, community-based AYA focused partners, local DOHs, and schools. By participating in the Westat-led ATN OCC, CNH is uniquely positioned to contribute to advancing the National HIV/AIDS Strategy and the national plan of Ending the HIV Epidemic in the United States.

国立儿童医院(CNH)CRS 尽管艾滋病毒流行取得了实质性进展，但13-24岁的青少年和青壮年(Aya) 与美国其他年龄段的人相比，艾滋病毒携带者的健康状况更差。 国立儿童医院(CNH)为儿童提供全面的艾滋病毒预防和治疗服务 大多数Aya来自哥伦比亚特区(DC)符合资格的大都市区(EMA)，包括三个国家 艾滋病毒流行热点-华盛顿特区和马里兰州的两个县(蒙哥马利和乔治王子的县)。 在华盛顿特区，它仍然是美国新艾滋病毒感染率最高的地区，阿雅有一个 艾滋病毒感染率高达0.3%，性传播感染发病率高，使其处于相当高的水平 感染艾滋病毒的风险。通过普遍的艾滋病毒咨询和选择退出筛查，CNH向 每年在哥伦比亚特区EMA提供艾滋病毒预防和检测服务的数千名Aya。目前以约300人为主 少数民族Black Aya在CNH接受暴露前预防和抗逆转录病毒治疗。CNH有一个 在地方、区域和国家科学网络内的长期合作历史，包括以前 参与青少年试验网络(ATN)。CNH已经成为一个成功的招聘网站 多项行业赞助的研究性新药临床试验，并收到了不间断的DC生产线 卫生部为艾滋病毒预防和检测提供了10多年的资金。CNH已经有了很好的历史 与当地和地区性社区组织建立伙伴关系，并在以下领域拥有良好的领导记录 在学术和社区调查人员的更广泛的当地社区内进行艾滋病毒研究， 包括在DC艾滋病研究中心和DC队列研究中的积极作用。的首要目标是 拟议的ATN CNH联合体选址将为Westat领导的ATN运营和协作中心做出贡献 (OCC)长期科学影响，同时扩大其在对当地直接公共卫生影响方面的作用， 地区性和全国性的艾滋病毒在阿亚之间流行。为实现这一目标，CNH将：(A)积极参与 由ATN执行人员确定的由Westat领导的ATN OCC临床试验的开发和实施 和科学领导委员会；(B)提供创新的解决方案，以优化招聘、注册和 在ATN研究中将Aya保留在DC EMA的多个地点，并确保当地实验室能力和 药房支持；(C)在实施和临床方面提出新的概念、途径和方法 科学，以及开发和优化针对Aya的生物医学预防和治疗工具；以及 (D)通过持续的CNH现场和AYA对Westat领导的ATN OCC领导模式做出有意义的贡献 社区参与，通过已建立的区域协作扩展网络协作 以临床、学术、社区为重点的AYA合作伙伴、当地DOHS和学校。通过参与 由Westat领导的ATN OCC，CNH处于独特的地位，为推进国家艾滋病毒/艾滋病战略做出贡献 以及结束美国艾滋病毒流行的国家计划。