Children's National Hospital Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)

国家儿童医院站点联盟 - HIV/艾滋病干预青少年医学试验网络 (ATN) 运营和合作中心（UM2 临床试验可选）

• 批准号: 10709605
• 负责人: Natella Yurievna Rakhmanina
• 金额: $ 33.92万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709605
• 关键词: AIDS prevention; Academy; Acquired Immunodeficiency Syndrome; Adolescent; Adolescent Medicine Trials Network; Adolescent and Young Adult; Adult; American; Area; Assessment tool; Behavioral Sciences; Black race; Capital; Caring; Child; Childhood; Chlamydia; Clinical; Clinical Sciences; Clinical Trials; Cohort Studies; Collaborations; Communities; Counseling; County; Data; Development; District of Columbia; Eligibility Determination; Enrollment; Ensure; Epidemic; European; Funding; Goals; Gonorrhea; Guidelines; HIV; HIV Infections; HIV diagnosis; HIV prevention trials network; HIV-infected adolescents; HIV/AIDS; Health; Health Services Accessibility; Hospitals; Hotlines; Human immunodeficiency virus test; Incidence; Industry; Infection; International Maternal Pediatric Adolescent AIDS Clinical Trials; Intervention; Investigational Drugs; Laboratories; Leadership; Maryland; Methodology; Minority; Modeling; National Children' s Study; Outcome; Participant; Pediatric HIV/AIDS Cohort Study; Pediatrics; Pharmacy facility; Physicians; Positioning Attribute; Prevalence; Prevention; Productivity; Psychosocial Assessment and Care; Public Health; Publishing; Readiness; Recording of previous events; Research; Research Personnel; Risk; Role; Schools; Sexually Transmitted Diseases; Site; Social Sciences; Teletherapy; United States; United States Dept. of Health and Human Services; United States National Institutes of Health; Washington; age group; aged; antiretroviral therapy; care systems; clinical center; community engagement; community organizations; cooking; high school; implementation science; innovation; metropolitan; novel; operation; pediatric human immunodeficiency virus; peer support; poor health outcome; pre-exposure prophylaxis; prevent; prevention service; programs; recruit; screening; testing services; tool; treatment services

ABSTRACT Children's National Hospital (CNH) CRS Despite the substantial progress in the HIV epidemic, adolescents, and young adults (AYA) aged 13-24 years living with HIV have worse health outcomes compared to any other age groups in the United States (US). Children's National Hospital (CNH), provides comprehensive HIV prevention and treatment services to the majority of AYA from the District of Columbia (DC) eligible metropolitan area (EMA) including three national HIV epidemic hotspots—Washington, DC, and two Maryland counties (Montgomery and Prince George's). Within DC, which continues to have the highest rates of new HIV infection in the United States, AYA have a high HIV prevalence of 0.3%, and high incidence of sexually transmitted infections, placing them at substantial risk for acquiring HIV. Through universal HIV counselling and opt-out screening, CNH reaches out to thousands of AYA in the DC EMA yearly with HIV prevention and testing services. Currently ~300 primarily minority Black AYA are in care at CNH for pre-exposure prophylaxis and antiretroviral treatment. CNH has a longstanding history of collaboration within local, regional, and national scientific networks, including prior participation in the Adolescent Trials Network (ATN). CNH has served as a successful recruitment site to multiple industry-sponsored investigational new drug clinical trials and received an uninterrupted line of DC Department of Health funding for HIV prevention and testing for more than 10 years. CNH has well-established partnerships with local and regional community-based organizations and a strong track-record of leadership in AYA HIV research within the broader local community of academic and community-based investigators, including its active role in DC Center for AIDS Research and DC Cohort Study. The overarching goal of the proposed ATN CNH consortium site is to contribute to the Westat-led ATN Operation and Collaboration Center (OCC) long-term scientific impact while expanding its role in delivering direct public health impacts on the local, regional, and national HIV epidemic among AYA. To achieve this goal, CNH will: (a) actively participate in the development and implementation of the Westat-led ATN OCC clinical trials identified by the ATN Executive and Scientific Leadership Committees; (b) deliver innovative solutions to optimize recruitment, enrollment, and retention of AYA at multiple sites in the DC EMA in ATN studies and ensure local laboratory capacity and pharmacy support; (c) propose novel concepts, approaches, and methodologies in implementation and clinical science, and development and optimization of biomedical prevention and treatment tools for AYA; and (d) meaningfully contribute to the Westat-led ATN OCC leadership model through sustained CNH site and AYA community engagement, expanding network collaborations through established regional collaborations among clinical, academic, community-based AYA focused partners, local DOHs, and schools. By participating in the Westat-led ATN OCC, CNH is uniquely positioned to contribute to advancing the National HIV/AIDS Strategy and the national plan of Ending the HIV Epidemic in the United States.

摘要 国立儿童医院 (CNH) CRS 尽管艾滋病毒流行取得了实质性进展，但 13-24 岁的青少年和年轻人 (AYA) 与美国任何其他年龄组相比，艾滋病毒感染者的健康状况更差。 国家儿童医院 (CNH) 为儿童提供全面的艾滋病毒预防和治疗服务 大多数 AYA 来自哥伦比亚特区 (DC) 符合条件的大都市区 (EMA)，其中包括三个全国性的 HIV 流行热点 — 华盛顿特区和马里兰州的两个县（蒙哥马利县和乔治王子城县）。 在华盛顿特区，新发艾滋病毒感染率仍然是美国最高的，AYA 拥有 艾滋病毒感染率高达 0.3%，性传播感染的发病率也很高，使这些国家处于相当高的水平 感染艾滋病毒的风险。通过普遍的艾滋病毒咨询和选择退出筛查，CNH 向 DC EMA 每年为数千名 AYA 提供艾滋病毒预防和检测服务。目前主要~300 少数黑人 AYA 在 CNH 接受暴露前预防和抗逆转录病毒治疗。离岸人民币有一个 地方、区域和国家科学网络内的长期合作历史，包括先前 参与青少年试验网络 (ATN)。 CNH 已成为一个成功的招聘网站 多个行业资助的研究性新药临床试验并获得不间断的 DC 线路 卫生部资助艾滋病毒预防和检测已有 10 多年。 CNH拥有完善的 与当地和区域社区组织的伙伴关系以及在这方面的良好领导记录 AYA HIV 研究在更广泛的当地学术界和社区调查人员的范围内进行， 包括其在华盛顿特区艾滋病研究中心和华盛顿特区队列研究中的积极作用。该组织的总体目标是 拟议的 ATN CNH 联盟站点将为 Westat 领导的 ATN 运营和协作中心做出贡献 (OCC) 长期科学影响，同时扩大其对当地、直接公共卫生影响的作用， AYA 中的区域和国家艾滋病毒流行情况。为实现这一目标，CNH 将： (a) 积极参与 开发和实施由 ATN 执行官确定的 Westat 主导的 ATN OCC 临床试验 和科学领导委员会； (b) 提供创新解决方案以优化招聘、入学和 在 ATN 研究中将 AYA 保留在 DC EMA 的多个地点，并确保当地实验室的能力和 药房支持； (c) 在实施和临床中提出新的概念、途径和方法 AYA生物医学防治工具的科学、开发和优化；和 (d) 通过持续的 CNH 网站和 AYA 为 Westat 领导的 ATN OCC 领导模式做出有意义的贡献 社区参与，通过建立区域合作扩大网络合作 临床、学术、以社区为基础的 AYA 重点合作伙伴、当地 DOH 和学校。通过参加 Westat 领导的 ATN OCC、CNH 具有独特的优势，可以为推进国家艾滋病毒/艾滋病战略做出贡献 以及美国结束艾滋病毒流行的国家计划。