Combined Experimental and Analytical Study of the Effects of Zone V Extensor Tendon Injuries on Hand Function

V区伸肌腱损伤对手功能影响的实验与分析相结合的研究

• 批准号: 10599982
• 负责人: Muturi G Muriuki
• 金额: $ 22.61万
• 依托单位: CHICAGO ASSN FOR RESEARCH & EDUC IN SCI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10599982
• 关键词: Affect; Aftercare; Algorithms; Amputees; Analysis of Variance; Anatomy; Biomechanics; Cadaver; Catalogs; Clinical Treatment; Communication; Data; Development; Experimental Models; Extensor; Fingers; Flexor; General Population; Goals; Grooming; Hand; Hand Injuries; Hand Strength; Hand functions; Hygiene; Incidence; Injury; Interruption; Laceration; Measures; Modeling; Motion; Occupational; Operative Surgical Procedures; Outcome; Outcome Assessment; Output; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Pattern; Persons; Play; Procedures; Quality of life; Recreation; Reporting; Research; Role; Rotation; Running; Severities; Skin; Specimen; Surface; System; Tendon Injuries; Tendon structure; Time; Trauma; Treatment outcome; Variant; Work; anterior cruciate ligament injury; disability; experimental group; experimental study; grasp; hand dysfunction; improved; mathematical model; model development; outcome prediction; sex; skeletal tissue; soft tissue; tool; treatment and outcome; treatment optimization

Extensor tendon injuries of the hand are common and potentially debilitating. The long-term objective of this research is to improve patient outcomes following extensor tendon injury. The first step towards this objective is to determine the effect of extensor tendon injury on patient function. Additional steps can then be taken to improve treatment and outcomes once the underlying causes of poor patient outcomes are known. The first step is the focus of this proposed work. Cadaveric experiments and mathematical modeling will be used to increase our understanding of the effect of extensor tendon injuries on hand function, and to improve treatments for extensor tendon injuries. In the cadaveric experiments the extensor tendons will be loaded to generate finger motion. Tendon excursion, tendon load, grip and finger rotation will be measured during these experiments. There will be two experimental groups with different patterns of extensor injury. Data collected from the first experimental group will be used to create mathematical models relating extensor tendon injury to finger function. The mathematical models will take simulated injury as an input and output finger motion and grip strength. An optimization procedure will be used to generate the models. Given the extensor tendon injury configuration in group one, the optimization will adjust the mathematical model parameters to minimize the difference between model output and group one data. These optimized mathematical models will then be given group two injury configurations as a system input. The accuracy of the mathematical models will be determined by comparing the model’s outputs to data collected from the second experimental group. The effect of extensor tendon injury on finger function will be determined using repeated measures analysis of variance. Accuracy of the mathematical models will be quantified using a similarity metric comparing the second group’s experimental data to the output of the mathematical models using group two’s set of simulated extensor injury.

手部的伸肌肌腱损伤是常见的，并且可能使人衰弱。的长期目标 本研究旨在改善伸肌腱损伤患者的预后。第一步 目的是确定伸肌腱损伤对患者功能的影响。然后可以执行其他步骤 一旦了解了患者不良结局的根本原因，就采取措施改善治疗和结局。的 第一步是这项拟议工作的重点。 尸体实验和数学建模将被用来增加我们对这种效应的理解 目的探讨伸肌腱损伤对手功能的影响，提高伸肌腱损伤的治疗水平。 在尸体实验中，伸肌肌腱将被加载以产生手指运动。肌腱 在这些实验期间，将测量偏移、肌腱负荷、抓握和手指旋转。将有两 实验组采用不同方式的伸肌损伤。从第一次实验中收集的数据 组将被用来创建数学模型，伸肌肌腱损伤手指功能。的 数学模型将模拟损伤作为输入和输出手指运动和握力。一个 优化程序将用于生成模型。鉴于伸肌肌腱损伤的形态， 第一组，优化将调整数学模型参数，以最小化 模型输出和第一组数据。 这些优化的数学模型，然后将给予第二组损伤配置作为系统输入。 数学模型的准确性将通过比较模型的输出和数据来确定 从第二个实验组收集。 将使用重复测量分析来确定伸肌腱损伤对手指功能的影响 方差。数学模型的准确性将使用相似性度量来量化， 第二组的实验数据，以数学模型的输出，用第二组的一套模拟 伸肌损伤