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Disrupted eye gaze perception as a biobehavioral marker of social dysfunction: An RDoC investigation

眼睛注视感知中断作为社会功能障碍的生物行为标志：RDoC 调查

基本信息

批准号：
10599983
负责人：
CYNTHIA ZURHELLEN BURTON
金额：
$ 59.61万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2023-04-02
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10599983
关键词：
Address Adolescent and Young Adult Age Area Bayesian Modeling Behavioral Behavioral Sciences Bipolar Disorder Brain Categories Clinical Cognition Cognitive Combined Modality Therapy Communities Complex Diagnosis Diagnostic Dimensions Discrimination Disease Emotions Employment Exhibits Eye Functional Magnetic Resonance Imaging Functional disorder Future Goals Human Impairment Independent Living Individual Intervention Investigation Literature Maps Mental disorders Mind Monkeys National Institute of Mental Health Neurobiology Neurosciences Participant Patient Recruitments Patients Perception Perceptual disturbance Pharmaceutical Preparations Phenotype Primates Productivity Psychiatric Diagnosis Psychophysics Psychoses Quality of life Reporting Research Research Domain Criteria Sampling Scanning Schizophrenia Sensory Social Development Social Functioning Social Phobia Testing Time Vision Visual Visual Cortex Visual System autism spectrum disorder biobehavior cognitive process cognitive training connectome disability effective therapy emotion regulation experience functional improvement gaze improved improved outcome indexing multimodality neural neural circuit neural correlate personalized medicine potential biomarker psychiatric symptom psychosocial recruit social social anxiety social cognition social communication social deficits theories therapy development trait treatment strategy

项目摘要

Project Summary/Abstract Social dysfunction is an intractable problem in a wide spectrum of psychiatric illnesses, undermining patients’ capacities for employment, independent living, and maintaining meaningful relationships. Identifying common markers of social impairment across disorders and understanding their mechanisms are prerequisites to developing targeted neurobiological treatments that can be applied productively across diagnoses and illness stages to improve functional outcome. This project focuses on eye gaze perception, the ability to accurately and efficiently discriminate others’ gaze direction, as a potential biomarker of social functioning that cuts across psychiatric diagnoses. This premise builds on both the monkey and human literatures showing gaze perception as a basic building block supporting higher-level social communication and social development, and reports of abnormal gaze perception in multiple psychiatric conditions accompanied by prominent social dysfunction (e.g., psychosis-spectrum disorders, autism-spectrum disorders, social phobia). A large sample (n= 225) of adolescent and young adult (age 14-30) psychiatric patients (regardless of diagnosis) with various degrees of impaired social functioning, and 75 demographically matched healthy controls will be recruited for this study. Participant’s psychiatric phenotypes, cognition, social cognition, and community functioning will be dimensionally characterized. Eye gaze perception will be assessed using a psychophysical task, and two metrics (precision, self-referential bias) that respectively tap into gaze perception disturbances at the visual perceptual and interpretation levels, independent of general deficits, will be derived using Bayesian modeling. A subset of the participants (150 psychiatric patients, 75 healthy controls) will additionally undergo multimodal fMRI to determine the functional and structural brain network features of altered gaze perception. The specific aims of this project are three fold: Aim 1) Determine the generality of gaze perception disturbances in psychiatric patients with prominent social dysfunction; 2) Map behavioral indices of gaze perception disturbances to dimensions of psychiatric phenotypes and core functional domains; and 3) Identify the neural correlates of altered gaze perception in psychiatric patients with social dysfunction. Successfully completing these specific aims will identify the specific basic deficits, clinical profile, and underlying neural circuits associated with social dysfunction that can be used to guide targeted, personalized treatments, thus advancing NIMH’s Strategic Objective 1 (describe neural circuits associated with mental illnesses and map the connectomes for mental illnesses) and Objective 3 (develop new treatments based on discoveries in neuroscience and behavioral science).