Nutrition, Genetics, and Evolution in the Cavefish Model of Autism-like Disorders

自闭症样疾病洞穴鱼模型中的营养、遗传学和进化

• 批准号: 10666247
• 负责人: Farzana Nasrin
• 金额: $ 18.64万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-25 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10666247
• 关键词: Nutrition; Genetics; Evolution; Cavefish; Model

The overarching goal of this research proposal is to identify new therapies by systemically investigating how the gut microbiota through nutrition alters brain functions, particularly by modifying activities within and between brain regions. The short-term goals of this research program are to develop tools to dissect the mechanisms that drive autism spectrum disorder (ASD)-like symptoms in a teleost model, which exhibits a similar composition of the gut microorganism to the ones of autism patients and core ASD-like behaviors.

这项研究提案的总体目标是通过系统地研究肠道微生物群如何通过营养改变大脑功能，特别是通过改变大脑区域内和之间的活动来确定新的疗法。这项研究计划的短期目标是开发工具来剖析硬骨鱼模型中驱动自闭症谱系障碍（ASD）样症状的机制，该模型显示出与自闭症患者和核心ASD样行为相似的肠道微生物组成。