Prostate cancer Active Surveillance Study (PASS) Cohort: Infrastructure Support for Cancer Research

前列腺癌主动监测研究 (PASS) 队列：癌症研究的基础设施支持

• 批准号: 10601448
• 负责人: DANIEL W. LIN
• 金额: $ 68.39万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601448
• 关键词: Prostate; cancer; Active; Surveillance; Study

PROJECT SUMMARY/ABSTRACT We propose to support the established Prostate cancer Active Surveillance Study (PASS) cohort, which is a large multi-institutional cohort of men with clinically localized prostate cancer who have elected active surveillance to manage their cancer. With broad eligibility criteria designed to represent the population of men who utilize active surveillance, the cohort has over 2,100 participants with extensive clinical and epidemiological data (demographic, lifestyle, quality of life, long-term outcomes) and longitudinal biospecimens (germline DNA, serum, plasma, urine, and prostate tissue) collected according to a standardized protocol. The cohort was established in 2008 in response to the growing evidence of prostate cancer overtreatment and the need for a prospective study to discover and validate biomarkers of prostate cancer progression, and to identify determinants of cancer progression and patient outcomes. Over the past decade, the cohort has amassed a wealth of data and biospecimens so that it serves as the foundation for addressing critical questions relevant to the optimal personalized management of early stage prostate cancer. The successful funding of this application will support a robust infrastructure for PASS that in turn will ensure the availability of PASS data and specimens to facilitate research addressing determinants of cancer progression, recurrence, and outcomes. A substantial proportion of these research endeavors are encompassed in currently funded federal grants, and the successful completion of the current and future projects relies on the continued success of the PASS enterprise. The impact of this cohort lies in its potential to investigate research questions of paramount importance: to identify better prognostic markers of prostate cancer aggressiveness; to understand the clinical management, progression and outcomes of early stage prostate cancer; to tailor the approach of active surveillance based on individual characteristics and preferences; to characterize associations between clinicopathologic factors, patient lifestyle, and disease biology; to develop new tools to communicate medical information to patients; and to understand decision- making among patients on active surveillance, in particular with regards to quality of life, anxiety, and regret . The successful completion of these transformative research endeavors will address unmet needs in the most commonly diagnosed male cancer and substantially reduce the current public health burden of early stage prostate cancer.

项目总结/摘要 我们建议支持已建立的前列腺癌主动监测研究（PASS）队列， 患有临床局限性前列腺癌的男性的大型多机构队列， 来控制他们的癌症。具有广泛的资格标准，旨在代表男性人口 该队列有超过2，100名参与者，他们利用积极的监测， 流行病学数据（人口统计学、生活方式、生活质量、长期结局）和纵向生物标本 根据标准化方案收集的细胞（生殖系DNA、血清、血浆、尿液和前列腺组织）。的 为了应对前列腺癌过度治疗的越来越多的证据和前列腺癌过度治疗的趋势，该队列于2008年建立。 需要一项前瞻性研究来发现和验证前列腺癌进展的生物标志物， 确定癌症进展和患者结局的决定因素。在过去的十年里，这一群体 积累了大量的数据和生物标本，使其成为解决关键问题的基础。 与早期前列腺癌的最佳个性化管理相关的问题。 该应用程序的成功资助将为PASS提供强大的基础设施，从而确保 PASS数据和样本的可用性，以促进针对癌症决定因素的研究 进展、复发和结局。这些研究工作的很大一部分是 包括在目前资助的联邦赠款，并成功完成当前和未来的 项目的成功依赖于PASS企业的持续成功。这一群体的影响在于其潜力， 研究最重要的研究问题：确定更好的前列腺预后标志物 癌症的侵袭性;了解早期阶段的临床管理，进展和结果 前列腺癌;根据个人特征调整积极监测的方法， 偏好;描述临床病理因素、患者生活方式和疾病之间的关联 生物学;开发新的工具，向患者传达医疗信息;并了解决策- 在积极监测的患者中，特别是在生活质量、焦虑和后悔方面。 这些变革性研究工作的成功完成将解决大多数国家未满足的需求。 常见的诊断男性癌症，并大大减少目前的公共卫生负担的早期阶段 前列腺癌