Prostate cancer Active Surveillance Study (PASS) Cohort: Infrastructure Support for Cancer Research

前列腺癌主动监测研究 (PASS) 队列：癌症研究的基础设施支持

• 批准号: 9816560
• 负责人: DANIEL W. LIN
• 金额: $ 153.45万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9816560
• 关键词: Address; Anxiety; Biological; Biological Markers; Biology; Biometry; Cancer Patient; Cessation of life; Characteristics; Clinical; Clinical Data; Clinical Management; Cohort Studies; Collection; Communities; DNA; Data; Databases; Decision Making; Diagnosis; Diet; Disease; Disease Progression; Disseminated Malignant Neoplasm; Economics; Eligibility Determination; Ensure; Epidemiology; Financial Hardship; Foundations; Funding; Future; Goals; Grant; Health; Individual; Infrastructure; Intervention; Left; Life Style; Malignant Neoplasms; Malignant neoplasm of prostate; Medical; Molecular; Monitor; Morbidity - disease rate; Newly Diagnosed; Outcome; Participant; Pathologic; Pathology; Patient-Focused Outcomes; Patients; Pattern; Physical activity; Plasma; Population; Prognostic Marker; Prospective Studies; Prostate; Protocols documentation; Public Health; Quality of life; Randomized; Recommendation; Recurrence; Regimen; Regrets; Research; Research Personnel; Resources; Risk stratification; Sampling; Selection Criteria; Serinus; Serum; Specimen; Standardization; Technical Expertise; Testing; Time; Tissues; Translating; Uncertainty; Urine; active method; adverse outcome; anticancer research; base; cancer biomarkers; cancer care; cancer diagnosis; cancer epidemiology; cohort; comparative; curative treatments; design; epidemiologic data; follow-up; improved; lifestyle factors; male; men; mortality; overtreatment; personalized approach; personalized management; preference; prospective; prostate cancer progression; prostate cancer risk; repository; response; risk prediction model; side effect; success; surveillance study; tool; tumor behavior; tumor progression

PROJECT SUMMARY/ABSTRACT We propose to support the established Prostate cancer Active Surveillance Study (PASS) cohort, which is a large multi-institutional cohort of men with clinically localized prostate cancer who have elected active surveillance to manage their cancer. With broad eligibility criteria designed to represent the population of men who utilize active surveillance, the cohort has over 2,100 participants with extensive clinical and epidemiological data (demographic, lifestyle, quality of life, long-term outcomes) and longitudinal biospecimens (germline DNA, serum, plasma, urine, and prostate tissue) collected according to a standardized protocol. The cohort was established in 2008 in response to the growing evidence of prostate cancer overtreatment and the need for a prospective study to discover and validate biomarkers of prostate cancer progression, and to identify determinants of cancer progression and patient outcomes. Over the past decade, the cohort has amassed a wealth of data and biospecimens so that it serves as the foundation for addressing critical questions relevant to the optimal personalized management of early stage prostate cancer. The successful funding of this application will support a robust infrastructure for PASS that in turn will ensure the availability of PASS data and specimens to facilitate research addressing determinants of cancer progression, recurrence, and outcomes. A substantial proportion of these research endeavors are encompassed in currently funded federal grants, and the successful completion of the current and future projects relies on the continued success of the PASS enterprise. The impact of this cohort lies in its potential to investigate research questions of paramount importance: to identify better prognostic markers of prostate cancer aggressiveness; to understand the clinical management, progression and outcomes of early stage prostate cancer; to tailor the approach of active surveillance based on individual characteristics and preferences; to characterize associations between clinicopathologic factors, patient lifestyle, and disease biology; to develop new tools to communicate medical information to patients; and to understand decision- making among patients on active surveillance, in particular with regards to quality of life, anxiety, and regret . The successful completion of these transformative research endeavors will address unmet needs in the most commonly diagnosed male cancer and substantially reduce the current public health burden of early stage prostate cancer.

项目总结/文摘