Visuomotor Coordinate Transformation During Drosophila Chasing Behavior

果蝇追逐行为过程中视觉运动坐标的转变

• 批准号: 10601535
• 负责人: Matthew Collie
• 金额: $ 4.14万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10601535
• 关键词: Address; Anatomy; Animals; Back; Behavior; Behavioral; Brain; Calcium; Complex; Coupling; Darkness; Discrimination; Dissection; Dissociation; Drosophila genus; Drosophila melanogaster; Environment; Eye Movements; Fluorescence; Frequencies; Genetic; Head; Head Movements; Human; Image; Injections; Insecta; Ipsilateral; Leg; Link; Locomotion; Mammals; Measures; Mediating; Motion; Motor; Movement; Neurons; Organism; Output; Pathway interactions; Pattern; Photic Stimulation; Population; Positioning Attribute; Presynaptic Terminals; Retina; Rotation; Side; Signal Transduction; Source; Speed; Stimulus; Synapses; System; Time; Visual; Visual Motion; Walking; Whole-Cell Recordings; Work; arm movement; connectome; detector; experimental study; fly; motor control; neural; neural network; object motion; optic flow; postsynaptic; rate of change; response; retinotopic; two-photon; vector; visual motor

Abstract Sensorimotor integration often requires the brain to transform its representation of space between different coordinate systems. The mechanism of visuomotor coordinate transformation has been heavily investigated from a theoretical perspective and in the context of visually-guided arm, head, and eye movements in mammals. However, the underlying neural computations are still not well-understood. Coordinate transformations are also essential to visuomotor behavior in insects, and I am now uniquely positioned to address this question by leveraging the full brain connectome and genetic toolkit available in the fruit fly Drosophila melanogaster. Indeed, I have discovered a neural network in the Drosophila brain that appears well-positioned to perform such an inference. Therefore, I will use two-photon calcium imaging and whole cell recordings in walking flies to functionally and anatomically dissect the circuitry that underlies steering during object pursuit behavior. In doing so, this project will provide a mechanistic dissection of the control systems and coordinate transformations that guide visuomotor coupling.

抽象的 感觉运动集成通常要求大脑在不同的空间中改变其空间的表示 坐标系。 Visuomotor坐标转换的机制已从 理论观点和哺乳动物中视觉引导的手臂，头部和眼睛运动的背景。 但是，基本的神经计算仍然没有得到充分理解。坐标转换也是 对于昆虫中的视觉运动行为必不可少的，我现在可以独特地解决这个问题 利用果蝇果蝇中可用的全脑连接组和遗传工具包。的确， 我在果蝇大脑中发现了一个神经网络，该网络看起来很适合执行这样的 推理。因此，我将在步行苍蝇中使用两光子钙成像和全细胞记录 在功能和解剖学上剖析对象追求行为过程中转向的电路。做 因此，该项目将提供控制系统和坐标转换的机械解剖 指南视觉运动耦合。