Visuomotor Coordinate Transformation During Drosophila Chasing Behavior

果蝇追逐行为过程中视觉运动坐标的转变

• 批准号: 10601535
• 负责人: Matthew Collie
• 金额: $ 4.14万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10601535
• 关键词: Address; Anatomy; Animals; Back; Behavior; Behavioral; Brain; Calcium; Complex; Coupling; Darkness; Discrimination; Dissection; Dissociation; Drosophila genus; Drosophila melanogaster; Environment; Eye Movements; Fluorescence; Frequencies; Genetic; Head; Head Movements; Human; Image; Injections; Insecta; Ipsilateral; Leg; Link; Locomotion; Mammals; Measures; Mediating; Motion; Motor; Movement; Neurons; Organism; Output; Pathway interactions; Pattern; Photic Stimulation; Population; Positioning Attribute; Presynaptic Terminals; Retina; Rotation; Side; Signal Transduction; Source; Speed; Stimulus; Synapses; System; Time; Visual; Visual Motion; Walking; Whole-Cell Recordings; Work; arm movement; connectome; detector; experimental study; fly; motor control; neural; neural network; object motion; optic flow; postsynaptic; rate of change; response; retinotopic; two-photon; vector; visual motor

Abstract Sensorimotor integration often requires the brain to transform its representation of space between different coordinate systems. The mechanism of visuomotor coordinate transformation has been heavily investigated from a theoretical perspective and in the context of visually-guided arm, head, and eye movements in mammals. However, the underlying neural computations are still not well-understood. Coordinate transformations are also essential to visuomotor behavior in insects, and I am now uniquely positioned to address this question by leveraging the full brain connectome and genetic toolkit available in the fruit fly Drosophila melanogaster. Indeed, I have discovered a neural network in the Drosophila brain that appears well-positioned to perform such an inference. Therefore, I will use two-photon calcium imaging and whole cell recordings in walking flies to functionally and anatomically dissect the circuitry that underlies steering during object pursuit behavior. In doing so, this project will provide a mechanistic dissection of the control systems and coordinate transformations that guide visuomotor coupling.

摘要 感觉运动整合通常需要大脑将其对空间的表征在不同的空间之间进行转换。 坐标系视觉坐标变换的机理已被大量研究， 一个理论的角度来看，在视觉引导的手臂，头部和眼睛的哺乳动物运动的背景下。 然而，底层的神经计算仍然没有得到很好的理解。坐标变换也是 昆虫的视觉行为是必不可少的，我现在处于独特的位置来解决这个问题， 利用果蝇的完整大脑连接体和遗传工具包。的确， 我在果蝇大脑中发现了一个神经网络，它似乎很适合执行这样的任务。 推论因此，我将使用双光子钙成像和全细胞记录在步行苍蝇， 从功能和解剖学上剖析了在目标追求行为期间作为转向基础的电路。做 因此，该项目将提供控制系统的机械解剖和协调转换， 引导视觉耦合。