Objectively Measured Sedentary Behavior and Physical Activity in PREVENTABLE Study

PREVENTABLE 研究中客观测量的久坐行为和体力活动

• 批准号: 10602461
• 负责人: SRINIVASAN BEDDHU
• 金额: $ 70.06万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10602461
• 关键词: Accelerometer; Activities of Daily Living; Address; Adult; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Ancillary Study; Behavior Therapy; Cardiovascular Diseases; Categories; Classification; Data; Dementia; Development; Diabetes Mellitus; Elderly; Energy Metabolism; Evaluation; Event; Exercise; Funding; Future; Goals; Hour; Incidence; Individual; Intervention; Knowledge; Lifting; Light; Lipids; Measures; Meta-Analysis; Metabolic; Obesity; Observational Study; Outcome; Parents; Participant; Patient Self-Report; Phase; Physical Function; Physical activity; Placebos; Positioning Attribute; Posture; Probability; Public Health; Publishing; Randomized; Randomized, Controlled Trials; Recommendation; Research Personnel; Resources; Rest; Risk; Risk Factors; Role; Running; Strenuous Exercise; Technology; Testing; Time; Walking; Weight; aged; atorvastatin; awake; cognitive function; dementia risk; design; disability; experience; frailty; improved; light intensity; longitudinal, prospective study; mild cognitive impairment; mortality; multidisciplinary; physical inactivity; physically handicapped; placebo group; preservation; prevent; prospective; recruit; sedentary; sedentary lifestyle; synergism; tv watching; vigorous intensity

Sedentary behavior (spending most of the awake time in sitting/ recumbent posture) and physical inactivity (lack of achieving weekly moderate/ vigorous physical activity goals) are not interchangeable terms but represent distinct domains; one could be physically active and achieve the weekly goal of 150 min/week of MVPA but still spend the rest of the awake hours sedentary. Technological advances have led to the development of accelerometers for objectively measuring the posture, duration and intensity of physical activities. “Pragmatic Evaluation of Events And Benefits of Lipid-lowering in older adults (PREVENTABLE)” Trial is a NIA funded ongoing randomized controlled trial evaluating the effects of a statin on cognitive function and physical disability outcomes in older adults (age ≥ 75 years). The trial is in recruitment phase with a target N of 20,000. Leveraging the resources of the parent study, we propose to recruit 2,500 participants in this ancillary study and objectively measure sedentary, standing and stepping durations and the number of steps/day with a validated accelerometer to examine two distinct questions of public health importance. First, higher levels of moderate/ vigorous physical activities have been associated with lower risk of developing Alzheimer’s disease or related dementias (ADRD). However, physical inactivity and sedentary behavior are distinct domains. Prospective longitudinal studies relating sedentary behavior with the risk of ADRD are lacking. Hence, in the first specific aim, in a longitudinal, prospective analysis, we will examine the hypothesis that longer sedentary duration increases risk of incident mild cognitive impairment (MCI)/ probable ADRD; whereas, trade-off of sedentary duration for stepping duration is associated with lower risk of these outcomes. Second, there are conflicting data on the associations of statins with physical disability/ physical activity. PREVENTABLE is examining the possible role of atorvastatin in preventing disability (but not physical activity). We propose to add objective measures of physical activity. In the second aim, we will examine the hypothesis that decrease in physical disability and preservation of functional ability with randomization to atorvastatin compared to placebo will result in higher physical activity levels and lower sedentary duration. The investigators on this multi-disciplinary team have the experience and expertise to carry out all aspects of the project. The proposed ancillary study will be well integrated into the pragmatic design of the parent trial and place minimal burden on participants and parent study staff. By adding rigorous measures of sedentary behavior and physical activity, this ancillary study will create synergy with the parent trial to enhance scientific yield by addressing an important gap in the parent study. If sedentary behavior is associated with incident MCI/ ADRD in older adults, the results of the current study will aid in the design of a future RCT to examine the effect of a sedentary behavior intervention to prevent ADRD in older adults.

久坐不动(醒着的大部分时间都是坐/卧姿势)和不活动 (缺乏达到每周适度/剧烈体力活动的目标)不是可以互换的术语，但 代表不同的领域；一个人可以进行体力活动，并实现每周150分钟的目标 MVPA，但在醒着的其余时间仍然是久坐不动。技术的进步导致了 用于客观测量身体运动姿势、持续时间和强度的加速度计的研制 活动。“对老年人降脂事件和益处的务实评估(可预防)” 试验是由NIA资助的一项正在进行的随机对照试验，评估他汀类药物对认知功能的影响 和老年人的身体残疾结果(年龄≥75岁)。试验正处于招募阶段，目标是 20,000人。利用家长研究的资源，我们建议招募2500名参与者 辅助性研究和客观测量久坐、站立和踏步的持续时间以及 每天使用经过验证的加速度计检查两个不同的公共卫生重要性问题。 首先，中等或剧烈的体育活动水平越高，患糖尿病的风险越低。 发展为阿尔茨海默病或相关痴呆(ADRD)。然而，缺乏运动和久坐不动 行为是不同的领域。关于久坐行为与高血压风险的前瞻性纵向研究 ADRD是缺乏的。因此，在第一个具体目标中，在纵向、前瞻性分析中，我们将检查 假设久坐时间较长会增加发生轻度认知障碍(MCI)的风险/可能 然而，久坐时间与踏步时间的权衡与较低的风险相关。 结果。 第二，关于他汀类药物与身体残疾/体力活动之间的关联，存在相互矛盾的数据。 可预防的是研究阿托伐他汀在预防残疾方面的可能作用(但不是体力活动)。 我们建议增加客观的体力活动指标。在第二个目标中，我们将检验这一假设 随机服用阿托伐他汀可减少肢体残疾和保留功能 与安慰剂相比，服用安慰剂会导致更高的体力活动水平和更短的久坐时间。 这个多学科团队中的调查人员拥有开展各方面工作的经验和专业知识 这个项目。拟议的辅助研究将很好地融入父母试验的务实设计中，并 将参与者和家长研究人员的负担降至最低。通过增加严格的久坐措施 行为和体力活动，这项辅助研究将创建与父母试验的协同效应，以增强科学性 通过解决父母研究中的一个重要差距来提高产量。如果久坐行为与事件MCI/相关 ADRD在老年人中的应用，当前研究的结果将有助于设计未来的RCT来检查 久坐行为干预预防老年人ADRD的效果。