权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Promoting paretic limb use in stroke survivors using exoskeleton and virtual reality technologies

使用外骨骼和虚拟现实技术促进中风幸存者使用偏瘫肢体

基本信息

批准号：
10605387
负责人：
Alexander Brunfeldt
金额：
$ 6.95万
依托单位：
GEORGETOWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-07 至 2024-09-06
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10605387
关键词：
3D virtual reality Activities of Daily Living Acute Adopted American Bilateral Biological Assay Biomedical Engineering Cause of Death Central Nervous System Chronic Phase Clinical Collaborations Couples Coupling Custom Data Electromyography Engineering Environment Feedback Force of Gravity Future Goals Hand Hemiplegia Hospitals Impairment Individual Institution Knowledge Learning Limb structure Manuals Measures Mentors Mentorship Monitor Movement Muscle Neurology Neurons Output Paresis Participant Patients Pattern Persons Phenotype Process Publications Recovery of Function Regulation Rehabilitation therapy Reporting Research Research Personnel Resistance Stroke Sum Surface System Techniques Technology Testing Therapeutic Tissues Training Translating United States Universities Upper Extremity Visual Weight Work acute stroke arm arm function biceps brachii muscle career chronic stroke control theory deltoid muscle design disability efficacious treatment exoskeleton experience functional disability hemiparesis improved individual patient innovation kinematics motor control neural neuromuscular next generation novel novel strategies recruit rehabilitation science restoration stroke patient stroke rehabilitation stroke survivor virtual virtual reality virtual reality environment virtual reality system

项目摘要

PROJECT SUMMARY Stroke is the 5th leading cause of death in the United States, and nearly 8 million Americans report it as their primary reason for disability. For many with hemiparesis caused by their stroke, existing rehabilitative therapies have failed to deliver sustained improvements in functional recovery. These therapies either focus on only the impaired limb or rely on training tasks with little resemblance to activities of daily living. Emerging research suggests that bilateral training may provide improvements beyond unilateral training alone, but the mechanisms underlying these benefits remain unknown. Therefore, the objective of this proposal is to determine the motor control and neuromuscular mechanisms responsible for bilateral coordinated reaching in stroke. To do this, we have developed a rehabilitation platform that uses virtual reality and exoskeleton technologies to provide the task and environmental constraints necessary to increase the use of the paretic limb in chronic stroke survivors. Our preliminary results in healthy controls and 4 stroke participants show that our system can change both the kinematic and neuromuscular control of upper extremity reaching. Our overarching hypothesis is that hemiplegic stroke participants respond these novel task and environmental constraints by adopting an optimal reaching strategy that manifests as systematic changes in impaired arm displacement and muscle activity. Specifically, in Aim 1 we will explore the tradeoff between arm displacement and muscle activity during a bimanual reaching task and in Aim 2, we will establish a neuromuscular mechanism of impaired limb recruitment during this task. Specifically, we use an advanced electromyographical technique to measure coactivation of homologous muscle pairs. Together, these two Aims will identify the kinematic and neuromuscular mechanisms responsible for functional changes in bilateral coordination in chronic stroke survivors. The proposed research is supported by a well-established mentorship team the spans clinical neurology, rehabilitation sciences, and biomedical engineering. The work will be carried out in a unique collaboration between Georgetown University, the MedStar National Rehabilitation Hospital, and The Catholic University of America. These institutions are perfectly integrated to provide the clinical, technical, and intellectual environment needed to complete the proposed work. Training will include mentored clinical experience with acute and chronic stroke survivors and train the applicant in advanced engineering approaches to stroke rehabilitation. Finally, the training plan is designed to transition the applicant into an independent research career focused on exploring the next generation of technological solutions to therapeutic challenges.

项目总结