权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Characterization of Polysubstance Use: Combined Fentanyl and Methamphetamine

多物质使用的特征：芬太尼和甲基苯丙胺的组合

基本信息

批准号：
10607066
负责人：
Monica H Dawes
金额：
$ 4.77万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-01 至 2027-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10607066
关键词：
Acute Address Affect Animals Behavior Behavioral Brain Chronic Clinical Complex Cues Data Disease Dopamine Dose Drug Exposure Drug usage Dynorphins Event Exposure to Extinction Feeling Female Fentanyl Fiber Functional disorder Individual Intake Kinetics Laboratories Ligands Measures Methamphetamine Microdialysis Neurobiology Nucleus Accumbens Opioid Opioid Antagonist Periodicity Pharmaceutical Preparations Photometry Population Rattus Reinforcement Schedule Relapse Rewards Rodent Model Role Scanning Schedule Self Administration Sex Differences Signal Transduction Slice Stimulant System Techniques Time United States Withdrawal awake clinically significant dopamine system drug of abuse effective therapy fentanyl self-administration fentanyl use in vivo innovation insight invention kappa opioid receptors male mesolimbic system methamphetamine use mortality norbinaltorphimine novel opioid epidemic opioid overdose opioid use disorder overdose death pharmacologic polysubstance use pre-clinical research receptor function response sensor side effect substance use synthetic opioid transmission process

项目摘要

Project Summary The opioid epidemic currently affecting the United States has entered a new wave of mortality, with combined use of opioid and psychomotor simulants as a major contributing factor to the number of overdose deaths. Combined use of fentanyl and methamphetamine may be due to a number of factors, including greater rewarding effects, decreased negative side effects, and/or feelings that combined use is somehow ‘safer’ than use of fentanyl alone. For those reasons, there is a clear need to examine the differences in the behavioral and neurobiological alterations that occur following chronic use of fentanyl, methamphetamine, and these two substances in combination. My preliminary findings suggest that there is enhanced hypodopaminergia following combined use of fentanyl and methamphetamine (COMBO) when compared to fentanyl use alone. I have determined that 1) in both male and female rats, elicited DA release was decreased in COMBO animals compared to fentanyl alone animals and; (2) male COMBO animals had greater response rates and responded more on a progressive ratio schedule of reinforcement. Therefore, this study aims to investigate the scarcely studied combination of fentanyl and methamphetamine via a three-pronged approach examining behavioral and neurobiological alterations to the DA system through self-administration, microdialysis and fast scan cyclic voltammetry, and the use of the novel photosensor dLight during behavioral responding. Collectively, the proposed aims will provide insight into the neurobiological and behavioral differences elicited by combined use of fentanyl and methamphetamine, an under-studied topic that is highly relevant for the current state of the opioid epidemic in the United States.

项目总结