Early Neurodevelopmental Trajectories of Typical and Atypical Language Acquisition
典型和非典型语言习得的早期神经发育轨迹
基本信息
- 批准号:10607353
- 负责人:
- 金额:$ 3.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-01-19 至 2026-01-18
- 项目状态:未结题
- 来源:
- 关键词:AffectAge MonthsAnisotropyAreaBehavioralBirthBrainBrain regionCerebellumCerebrumChildChildhoodCommunicationContralateralCorpus CallosumCouplingDataDevelopmentDiffusion Magnetic Resonance ImagingDiseaseEarly DiagnosisEarly InterventionEarly identificationEducational process of instructingEmotionalEmploymentEnvironmentEtiologyExhibitsFellowshipFoundationsFunctional Magnetic Resonance ImagingFundingFutureGeneral PopulationHigh PrevalenceImageIndividual DifferencesInfantInformation DisseminationInfrastructureJapaneseLanguageLanguage DelaysLanguage DevelopmentLanguage Development DisordersLeftLifeLiteratureLongitudinal StudiesMagnetic Resonance ImagingMeasuresMethodsNational Institute of Child Health and Human DevelopmentNational Research Service AwardsNeurodevelopmental DisorderNeurosciencesNewborn InfantOutcomePatternPopulationPrevalencePublic HealthResearchResearch TrainingResourcesRestRiskRoleSample SizeSign LanguageSleepSocial outcomeSpeechStatistical ModelsStimulusStreamStructureTherapeutic InterventionTimeToddlerTrainingUnited States National Institutes of Healthadult with autism spectrum disorderadverse outcomeautism spectrum disordercareercollaborative environmentconnectomeearly detection biomarkerseffective interventionexperiencegraduate studenthigh riskimaging studyimprovedindexinginfancylanguage impairmentlanguage outcomelanguage processinglongitudinal designneuralneural networkneurodevelopmentneuroimagingnon-Nativepostnatalresponseskillsspeech processingsupport networksymptomatologytractographywhite matter
项目摘要
Project Summary/Abstract
Developmental language impairments are common in the general population, affecting approximately 1 in 10
children. Despite this prevalence, little is known about the etiology of language difficulties observed in conditions
such as Autism Spectrum Disorder (ASD). Earlier therapeutic interventions for language impairments have
consistently been associated with better language and social outcomes, making it important to develop a better
understanding of the neural apparatus supporting successful language acquisition during the first year of life.
This project will improve our understanding of language development by longitudinally examining how neural
language processing and language network connectivity before an infant’s first birthday relate to later trajectories
of receptive and expressive language skills.
This proposal will leverage data from two ongoing NIH-funded longitudinal studies to examine the neural
processing of native vs. non-native language (Aim 1), functional connectivity within language networks (Aim 2),
and the structure of white matter tracts supporting cross-talk between language hubs (Aim 3). Language delays
have been associated with aberrant language-related neural activity and network connectivity in both typically
and atypically developing populations. Yet although newborns can already distinguish their native language from
other languages, no study has longitudinally examined the neural signatures of native language learning in early
infancy. Importantly, infant imaging studies have seldom employed adequate sample sizes and repeated
observations necessary for rigorous assessment of neurodevelopmental changes in brain connectivity within
language networks. Here, fMRI data collected with a stimulus-evoked language paradigm as part of the UCLA
ACE (NICHD P50 HD055784) will be used to chart neural responses associated with native language learning
during the first year of life in infants at high and low risk for ASD. Longitudinal resting-state fMRI and Diffusion
Tensor Imaging (DTI) data from the Baby Connectome Project (1U01MH110274) will be used to thoroughly
characterize the early development of functional and structural connectivity, respectively, across brain regions
implicated in language processing. Finally, across all aims, differences in brain activity and connectivity during
infancy will be related to later language trajectories to identify early predictors of atypical language development.
The candidate, Lauren Wagner, will carry out these studies as a Neuroscience graduate student at UCLA under
the tutelage of Drs. Mirella Dapretto and Lucina Uddin who, together, have vast expertise in neurodevelopment,
pediatric imaging, language development, advanced neuroimaging methods, and ASD. UCLA’s infrastructure,
collaborative environment, and research training resources offer the candidate an ideal training environment in
which to carry out these aims. This F31 NRSA Fellowship will provide the applicant with comprehensive training
in MRI, statistical modeling, teaching, and dissemination of results that, altogether, will lay the foundation for a
successful academic research career focusing on neurodevelopmental disorders affecting language acquisition.
项目总结/文摘
项目成果
期刊论文数量(0)
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