Early Neurodevelopmental Trajectories of Typical and Atypical Language Acquisition

典型和非典型语言习得的早期神经发育轨迹

• 批准号: 10607353
• 负责人: Lauren E Wagner
• 金额: $ 3.97万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-19 至 2026-01-18
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10607353
• 关键词: Affect; Age Months; Anisotropy; Area; Behavioral; Birth; Brain; Brain region; Cerebellum; Cerebrum; Child; Childhood; Communication; Contralateral; Corpus Callosum; Coupling; Data; Development; Diffusion Magnetic Resonance Imaging; Disease; Early Diagnosis; Early Intervention; Early identification; Educational process of instructing; Emotional; Employment; Environment; Etiology; Exhibits; Fellowship; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; General Population; High Prevalence; Image; Individual Differences; Infant; Information Dissemination; Infrastructure; Japanese; Language; Language Delays; Language Development; Language Development Disorders; Left; Life; Literature; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Methods; National Institute of Child Health and Human Development; National Research Service Awards; Neurodevelopmental Disorder; Neurosciences; Newborn Infant; Outcome; Pattern; Population; Prevalence; Public Health; Research; Research Training; Resources; Rest; Risk; Role; Sample Size; Sign Language; Sleep; Social outcome; Speech; Statistical Models; Stimulus; Stream; Structure; Therapeutic Intervention; Time; Toddler; Training; United States National Institutes of Health; adult with autism spectrum disorder; adverse outcome; autism spectrum disorder; career; collaborative environment; connectome; early detection biomarkers; effective intervention; experience; graduate student; high risk; imaging study; improved; indexing; infancy; language impairment; language outcome; language processing; longitudinal design; neural; neural network; neurodevelopment; neuroimaging; non-Native; postnatal; response; skills; speech processing; support network; symptomatology; tractography; white matter

Project Summary/Abstract Developmental language impairments are common in the general population, affecting approximately 1 in 10 children. Despite this prevalence, little is known about the etiology of language difficulties observed in conditions such as Autism Spectrum Disorder (ASD). Earlier therapeutic interventions for language impairments have consistently been associated with better language and social outcomes, making it important to develop a better understanding of the neural apparatus supporting successful language acquisition during the first year of life. This project will improve our understanding of language development by longitudinally examining how neural language processing and language network connectivity before an infant’s first birthday relate to later trajectories of receptive and expressive language skills. This proposal will leverage data from two ongoing NIH-funded longitudinal studies to examine the neural processing of native vs. non-native language (Aim 1), functional connectivity within language networks (Aim 2), and the structure of white matter tracts supporting cross-talk between language hubs (Aim 3). Language delays have been associated with aberrant language-related neural activity and network connectivity in both typically and atypically developing populations. Yet although newborns can already distinguish their native language from other languages, no study has longitudinally examined the neural signatures of native language learning in early infancy. Importantly, infant imaging studies have seldom employed adequate sample sizes and repeated observations necessary for rigorous assessment of neurodevelopmental changes in brain connectivity within language networks. Here, fMRI data collected with a stimulus-evoked language paradigm as part of the UCLA ACE (NICHD P50 HD055784) will be used to chart neural responses associated with native language learning during the first year of life in infants at high and low risk for ASD. Longitudinal resting-state fMRI and Diffusion Tensor Imaging (DTI) data from the Baby Connectome Project (1U01MH110274) will be used to thoroughly characterize the early development of functional and structural connectivity, respectively, across brain regions implicated in language processing. Finally, across all aims, differences in brain activity and connectivity during infancy will be related to later language trajectories to identify early predictors of atypical language development. The candidate, Lauren Wagner, will carry out these studies as a Neuroscience graduate student at UCLA under the tutelage of Drs. Mirella Dapretto and Lucina Uddin who, together, have vast expertise in neurodevelopment, pediatric imaging, language development, advanced neuroimaging methods, and ASD. UCLA’s infrastructure, collaborative environment, and research training resources offer the candidate an ideal training environment in which to carry out these aims. This F31 NRSA Fellowship will provide the applicant with comprehensive training in MRI, statistical modeling, teaching, and dissemination of results that, altogether, will lay the foundation for a successful academic research career focusing on neurodevelopmental disorders affecting language acquisition.

项目总结/文摘