GABAergic alterations in the BNST to VTA circuit following morphine withdrawal

吗啡戒断后 BNST 至 VTA 回路的 GABA 能变化

基本信息

  • 批准号:
    10607287
  • 负责人:
  • 金额:
    $ 3.92万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-01-01 至 2026-12-31
  • 项目状态:
    未结题

项目摘要

Project Summary/Abstract The opioid epidemic is a continuously growing problem in the United States and across the world. It has profound personal, social, and economic consequences. Opioid use can become Opioid Use Disorder (OUD) in many individuals. OUD consists of several stages, one of which is a highly dysphoric withdrawal syndrome known as Opioid Withdrawal Syndrome (OWS). The withdrawal symptoms, including sleep dysregulation, and fear of those symptoms often contributes drastically to relapse. We do not currently understand all of the neurobiological mechanisms underlying opioid withdrawal, nor how particular circuits are modified by opioid withdrawal. It is well known, however, that two brain regions, the bed nucleus of the stria terminalis (BNST) and the ventral tegmental area (VTA), are involved in some capacity. In the two aims of this proposal, the experiments will help to understand how the pathway between these two regions is modified by opioid withdrawal. Our preliminary data shows that the GABAergic neurons in the BNST are altered by withdrawal. BNSTGABA neurons make up the bulk of the BNST neurons projecting to the VTA, where they synapse onto VTAGABA neurons, and have been implicated in positive reinforcement. This project utilizes viral-manipulations, behavioral studies, and electrophysiological examinations to carefully and specifically determine the effects of withdrawal in the BNST. In the second portion of this proposal, the experiments are focused on the output of this pathway in the VTA as well as a knockdown of this pathway to elucidate the role of this pathway in controlling behavior.
项目总结/摘要 阿片类药物流行病在美国和世界各地都是一个不断增长的问题。具有深刻 个人,社会和经济后果。阿片类药物的使用在许多情况下会成为阿片类药物使用障碍(OUD)。 个体OUD包括几个阶段,其中之一是高度烦躁的戒断综合征, 阿片类药物戒断综合征(OWS)。戒断症状,包括睡眠失调,以及对那些 症状往往大大有助于复发。我们目前还不了解所有的神经生物学 阿片类药物戒断的潜在机制,也不知道阿片类药物戒断如何改变特定的回路。公 然而,已知两个大脑区域,终纹床核(BNST)和腹侧被盖 (1)在一定的能力范围内。在这一建议的两个目标中,实验将有助于 了解这两个区域之间的通路如何被阿片类药物戒断所改变。我们的初步数据 表明BNST中的GABA能神经元因戒断而改变。BNSTGABA神经元构成了 BNST神经元投射到VTA,在那里它们突触到VTAGABA神经元,并且已经被 与积极强化有关该项目利用病毒操纵,行为研究, 电生理检查,以仔细和具体地确定BNST中戒断的影响。 在该提案的第二部分中,实验集中于VTA中该途径的输出, 以及敲除该通路以阐明该通路在控制行为中的作用。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Madigan Bedard其他文献

Madigan Bedard的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

相似海外基金

RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 3.92万
  • 项目类别:
    Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 3.92万
  • 项目类别:
    Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 3.92万
  • 项目类别:
    Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 3.92万
  • 项目类别:
    Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 3.92万
  • 项目类别:
    Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 3.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 3.92万
  • 项目类别:
    Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
  • 批准号:
    2301846
  • 财政年份:
    2023
  • 资助金额:
    $ 3.92万
  • 项目类别:
    Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 3.92万
  • 项目类别:
    Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
  • 批准号:
    23K16076
  • 财政年份:
    2023
  • 资助金额:
    $ 3.92万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了