Strategies for tuberculosis control in prisons
Strategies for tuberculosis control in prisons
批准号:
10607550
负责人:
Jason Randolph Andrews
金额:
$63.77万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
未结题
起止时间:
2017-03-01 至 2028-02-29
关键词:
AccelerationAddressAlgorithmsAmericasBenchmarkingBiological MarkersBloodBrazilCOVID-19COVID-19 pandemicCause of DeathCessation of lifeCohort StudiesCommunicable DiseasesCommunitiesConsciousCountryDataDetectionDigital RadiographyDigital X-RayDiseaseElectricityEnrollmentEpidemicFutureGene Expression ProfilingGenomicsGoalsHaplotypesHealthHealth protectionImageImmune responseImprisonmentIncidenceIndividualInfectionLongitudinal cohortLongitudinal trendsLow Dose RadiationMass ScreeningMeasuresMethodsMolecularMonitorMycobacterium tuberculosisNotificationParticipantPersonsPopulationPopulation SizesPrevalencePreventionPrevention MeasuresPreventive therapyPrisonsRecommendationResource-limited settingRiskRoentgen RaysSamplingSpecificitySputumSystemTestingThoracic RadiographyTimeTuberculosisTuberculosis diagnosisValidationWorkcase findingcohortcostcost effectivecost effectivenessdeep learningdeep learning algorithmdensitydiagnostic accuracyeffective therapygenome sequencinggenomic datahigh riskhigh risk populationimprovedlow and middle-income countriesmathematical modelmortalitynew technologynovelnovel strategiesportabilitypreventprogression riskscreeningsobrietysuccesstooltransmission processtrendvirtualwhole genome
中文摘要
项目摘要
结核病仍然是全世界死亡的主要原因之一,尽管
广泛提供有效的治疗和预防措施。监狱港
世界上结核病发病率最高的国家之一,在许多地区,
惩教机构的负担越来越重。世卫组织现在建议活跃病例
在监狱和其他高负担环境中发现结核病,但缺乏
如何准确和有效地及早发现病例以减少传播的证据。
为了解决这些差距,我们提出了一个前景队列研究中的监禁
巴西中西部结核病高负担监狱中的个人:1)评估
使用便携式数字X光片,自动判读,以便深入查找病例;
2)确定基因组数据是否可以用于跟踪在
人口水平; 3)使用数学模型来确定有效的,可扩展的
监狱结核病发现和预防策略。我们将测试
假设:1)自动判读X射线可以达到WHO目标产品
在被监禁的个人中,作为筛选测试的准确性,
在无症状或早期疾病的患者中; 2)新兴的动态方法
可用于监测传播趋势; 3)系列筛查结合
预防性治疗将是一种具有成本效益和影响力的结核病治疗方法
全球高负荷监狱的控制。总体而言,该项目将解决以下方面的重大差距:
结核病的诊断和预防在一个庞大的,服务不足,高风险的人口,
来保护他们的健康和他们社区的健康。
英文摘要
Project Summary
Tuberculosis remains one of the leading causes of death worldwide, despite the
widespread availability of effective treatment and prevention measures. Prisons harbor
among the highest rates of tuberculosis worldwide, and, in many regions, tuberculosis
burden in correctional settings is growing. The WHO now recommends active case
finding for tuberculosis in prisons and other high burden settings, but there is a dearth of
evidence for how to accurate and efficiently identify cases early to reduce transmission.
To address these gaps, we propose to a prospect cohort study among incarcerated
individuals in high tuberculosis burden prisons in Central Western Brazil to: 1) evaluate
the use of portable, digital x-rays with automated interpretation for intensive case finding;
2) determine whether genomic data can be used to track transmission rates at the
population level; and 3) use mathematical models to identify effective, scalable
strategies for tuberculosis case finding and prevention in prisons. We will test the
hypotheses that: 1) x-ray with automated interpretation can achieve WHO target product
profile thresholds for accuracy as a screening test among incarcerated individuals, even
among those with asymptomatic or early disease; 2) emerging phylodynamic methods
can be used to monitor trends in transmission; and 3) serial screening combined with
preventive therapy would be a cost-effective and impactful approach for tuberculosis
control in high-burden prisons globally. Overall, this project will address critical gaps in
tuberculosis diagnosis and prevention among a large, underserved, high-risk population,
to protect their health and the health of their communities.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Point-of-care pharmacogenomic testing to optimize isoniazid dosing for tuberculosis prevention
-
批准号:10709589
-
项目类别:
-
资助金额:$18.94万
-
财政年份:2022
-
负责人:Jason Randolph Andrews
-
依托单位:
Point-of-care pharmacogenomic testing to optimize isoniazid dosing for tuberculosis prevention
-
批准号:10537650
-
项目类别:
-
资助金额:$23.25万
-
财政年份:2022
-
负责人:Jason Randolph Andrews
-
依托单位:
Evaluation of a point-of-care immunochromatographic assay for enteric fever
-
批准号:10392476
-
项目类别:
-
资助金额:$14.18万
-
财政年份:2021
-
负责人:Jason Randolph Andrews
-
依托单位:
Characterizing infectiousness of subclinical TB and identifying novel early diagnostic strategies for preventing transmission
-
批准号:10362565
-
项目类别:
-
资助金额:$15.07万
-
财政年份:2020
-
负责人:Jason Randolph Andrews
-
依托单位:
Characterizing infectiousness of subclinical TB and identifying novel early diagnostic strategies for preventing transmission
-
批准号:10579176
-
项目类别:
-
资助金额:$15.48万
-
财政年份:2020
-
负责人:Jason Randolph Andrews
-
依托单位:
Characterizing infectiousness of subclinical TB and identifying novel early diagnostic strategies for preventing transmission
-
批准号:9889831
-
项目类别:
-
资助金额:$15.77万
-
财政年份:2020
-
负责人:Jason Randolph Andrews
-
依托单位:
Congregate air sampling for population-based detection of tuberculosis
-
批准号:9167046
-
项目类别:
-
资助金额:$197.09万
-
财政年份:2016
-
负责人:Jason Randolph Andrews
-
依托单位:
Network Models for Evaluating HIV-associated MDR TB transmission and control
-
批准号:8724335
-
项目类别:
-
资助金额:$13.72万
-
财政年份:2013
-
负责人:Jason Randolph Andrews
-
依托单位:
Network Models for Evaluating HIV-associated MDR TB transmission and control
-
批准号:9100638
-
项目类别:
-
资助金额:$13.72万
-
财政年份:2013
-
负责人:Jason Randolph Andrews
-
依托单位:
Network Models for Evaluating HIV-associated MDR TB transmission and control
-
批准号:8466080
-
项目类别:
-
资助金额:$5.0万
-
财政年份:2013
-
负责人:Jason Randolph Andrews
-
依托单位:
Network Models for Evaluating HIV-associated MDR TB transmission and control
-
批准号:8798824
-
项目类别:
-
资助金额:$8.71万
-
财政年份:2013
-
负责人:Jason Randolph Andrews
-
依托单位:
海外基金