Integrative Health Sciences Facility Core

综合健康科学设施核心

• 批准号: 10606562
• 负责人: Anil Vachani
• 金额: $ 35.33万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10606562
• 关键词: Address; Affect; Air Pollutants; Air Pollution; Area; Back; Basic Science; Big Data; Bioinformatics; Biological; Biological Markers; Biology; Biometry; Biosensor; Cells; Clinical; Clinical Research; Clinical Trials; Collection; Communication; Communities; Core Facility; Data; Database Management Systems; Development; Disease; Disease Management; Electronic Health Record; Electronic cigarette; Environmental Exposure; Environmental Health; Exposure to; Fostering; Health Sciences; Human; Human Resources; Individual; Informatics; Information Dissemination; Institutional Review Boards; Integrative Medicine; Intervention Trial; Laboratories; Maps; Measures; Mission; Nature; Neurosciences; Observational Study; Outcome; Participant; Patients; Performance; Phenotype; Pilot Projects; Population; Population Sciences; Predisposition; Process; Prognostic Marker; Public Health; Publications; Questionnaires; Reader; Recording of previous events; Research; Research Design; Research Personnel; Research Subjects; Research Support; Resources; Retrospective Studies; Risk; Sampling; Services; Specimen Handling; Statistical Data Interpretation; Statistical Methods; Strategic vision; Technology; Testing; Therapeutic Intervention; Toxicant exposure; Toxicokinetics; Training Activity; Training Support; Translating; Translational Research; Translations; Work; adverse outcome; analytical method; biobank; biomarker validation; biomedical informatics; combustible cigarette; community based participatory research; community engagement; cytate; data management; density; design; disorder risk; environment related cancer; environmental toxicology; epidemiology study; exposed human population; fundamental research; genetic information; high dimensionality; human subject; imaging study; innovation; lung health; member; non-genetic; novel; patient oriented research; pre-clinical; preclinical study; predictive marker; prevent; preventive intervention; quality assurance; recruit; tool; training opportunity; translational study; vapor; virtual

INTEGRATIVE HEALTH SCIENCES FACILITY CORE (IHSFC): ABSTRACT The IHSFC is the entity that enables CEET investigators to perform translational environmental health research that impacts individuals and communities. Its mission includes (1) support of the translation of basic science observations that relate environmental exposures to adverse outcomes into human studies that detect, prevent and/or manage diseases induced or exacerbated by these exposures and (2) to translate EHS questions derived from the community into testable hypotheses that can be addressed with human studies. Services provided by the IHSFC to CEET investigators include: (a) Human Studies Design and Performance Services, (b) Population Exposure Services, (c) Pre-clinical and Human Exposure Laboratories, (d) the CEET Virtual Biorepository and (e) Biostatistics Services. The Population Exposure Services now has expertise in GIS technology, ArcGIS tools, cartographic mapping, geospatial analysis to measure the external exposome. Population science-based projects that require biomarker support in the study design are referred to the Translational Biomarker Core, and those that generate “big-data” in their study design are referred to the Exposure Biology Informatics Core. The IHSFC acts as a bridge to the Community Engagement Core (CEC) and communicates in a bi-directional manner to formulate community-based questions and concerns into specific hypotheses for CEET investigators to address by research and communicate results of the studies back to community members. Studies supported by the IHSFC include those involving the integrated thematic areas of Air Pollution & Lung Health, Environmental Exposures & Cancer, Windows-of-Susceptibility and Environmental Neuroscience, as well as novel studies initiated via pilot projects. Over the past four years, the IHSFC has supported 51 separate studies involving 28 different CEET investigators that have generated 46 publications. Efforts by the IHSFC will ultimately result in achieving Precision Public Health (PPH) - the prediction of who is at risk of exposure, who is at risk for disease, and the identification of predictive and prognostic biomarkers.

综合健康科学设施核心(IHSFC)：摘要 IHSFC是使CEET调查人员能够进行翻译环境健康研究的实体 这会影响到个人和社区。其任务包括：(1)支持基础科学的翻译 将环境暴露于不良后果的观察纳入人体研究，以检测、预防 和/或管理由这些暴露引起或加剧的疾病，以及(2)将衍生的EHS问题转化为 从社区转化为可测试的假设，可以通过人体研究来解决。提供的服务由 IHSFC到CEET的调查人员包括：(A)人体研究设计和绩效服务，(B)人口 暴露服务，(C)临床前和人类暴露实验室，(D)CEET虚拟生物库和 (E)生物统计服务。人口暴露服务现在拥有地理信息系统技术的专业知识，ArcGIS 测量外部曝光量的工具、地图绘制、地理空间分析。以人口科学为基础 在研究设计中需要生物标记支持的项目被提交给翻译生物标记核心，以及 那些在研究设计中产生“大数据”的人被称为“暴露生物学信息学核心”。这个 IHSFC充当到社区参与核心(CEC)的桥梁，并以双向方式进行通信 将基于社区的问题和关切转化为具体的假设，供CEET调查人员 通过研究发表讲话，并将研究结果反馈给社区成员。支持的研究 IHSFC的报告包括涉及空气污染和肺健康、环境等综合主题领域的报告 暴露与癌症、易感窗口和环境神经科学，以及新的研究 通过试点项目启动。在过去的四年里，IHSFC支持了51项不同的研究，涉及28项 不同的CEET调查人员产生了46份出版物。IHSFC的努力最终将导致 实现精确的公共卫生(PPH)-预测谁有接触的风险，谁有疾病的风险， 以及预测和预后生物标记物的识别。