Novel Insights into the Pathobiology of Alphavirus Infections

对甲病毒感染病理学的新见解

• 批准号: nhmrc : 1106411
• 负责人: Dr Lara Herrero
• 金额: $ 56.93万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-insights-pathobiology-alphavirus-infections/662904
• 关键词: Novel; Insights; into; Pathobiology; Alphavirus

Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.

蚊子传播的病毒感染在世界范围内以惊人的速度增加。罗斯河病毒在澳大利亚、巴布亚新几内亚和太平洋岛屿的部分地区流行，而基孔肯雅病毒在全球分布，并导致涉及数百万人的反复流行病。这些病毒会在感染后数月内引起严重的肌肉骨骼疾病。该项目旨在确定这些病毒如何与人类宿主相互作用以引起疾病，并可能为新的治疗方法提供基础。