Internally and externally driven arousal changes in neural activity and hemodynamics

内部和外部驱动的神经活动和血流动力学的唤醒变化

• 批准号: 10609439
• 负责人: Deepa Issar
• 金额: $ 5.27万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609439
• 关键词: Affect; Alzheimer' s Disease; Arousal; Attention; Attention Deficit Disorder; Auditory; Behavior; Behavioral; Biological Markers; Blood Vessels; Brain; Brain Diseases; Brain Stem; Brain region; Cells; Cerebrovascular system; Clinical; Cognition; Cognition Disorders; Cognitive; Cognitive deficits; Communities; Coupled; Cues; Detection; Diameter; Discrimination; Disease; Electroencephalography; Electrophysiology (science); Engineering; Environment; Functional Magnetic Resonance Imaging; Global Change; Goals; Heart Rate; Hour; Impairment; Individual; Link; Macaca mulatta; Measures; Modality; Monkeys; Near-Infrared Spectroscopy; Neurosciences; Optics; Performance; Perfusion; Physicians; Physiology; Population; Positioning Attribute; Prefrontal Cortex; Psychophysics; Pupil; Reaction Time; Reporting; Research; Rest; Scalp structure; Schizophrenia; Scientist; Short-Term Memory; Signal Transduction; Stimulus; System; Terminology; Testing; Training; Universities; Variant; Wakefulness; Work; alertness; behavior influence; biomarker identification; cerebral hemodynamics; circadian; cognitive function; cognitive task; diagnostic biomarker; experimental study; hemodynamics; insight; multimodality; nervous system disorder; neural; neuromechanism; recruit; skills; trend

PROJECT SUMMARY/ABSTRACT Our level of arousal influences almost all of the cognitive and behavioral abilities that allow us to engage with our environment. A variety of terminology has been used to describe arousal-related changes in cognition, including wakefulness, internal state, engagement, and alertness. Despite this ambiguity, it is clear that arousal is a global phenomenon that affects brain activity, systemic physiology, and behavior. Arousal deficits in behavior and systemic markers, such as heart rate and pupil diameter, are present in many neurologic disorders, including Alzheimer’s, schizophrenia, and attention deficit disorder. In order to use these non-invasive systemic measures of arousal as diagnostic markers, we need to understand how arousal level influences brain activity in neurotypical cognition and in turn leads to changes in behavior. The goal of this proposal is to investigate changes in brain activity that occur with fluctuations in arousal level. Specifically, we will study slow changes in simultaneously measured cortical neural population activity and cerebral hemodynamics. We will track arousal level using pupil diameter and heart rate. Our overarching hypothesis is that we can link minute-to-minute arousal fluctuations with slow changes in neural population activity and cerebral hemodynamics. In the first aim, we will study internally driven variations in arousal level that occur over hours and across the circadian cycle. In the second aim, we will probe arousal level using an external stimulus to assess whether we can modulate arousal- linked drifts in neural population activity and hemodynamics. Our strategy to record simultaneous population activity and hemodynamic changes in context of systemic parameters and behavior will allow us to comprehensively probe arousal-related changes and integrate arousal effects across the brain, body, and behavior. Results from this proposal will help to understand how deviations in arousal, measured via behavior and systemic physiology, could serve as biomarkers of changes in global brain activity that are present in neurologic disorders. This proposal will be completed in the interdisciplinary and collaborative training environment of Carnegie Mellon University and its Center for the Neural Basis of Cognition that consists of a large community of neuroscientists and engineers investigating brain activity underlying cognition and brain disorders. Under the guidance of Dr. Matt Smith, an expert in systems neuroscience, and Dr. Jana Kainerstorfer, an expert in biomedical optics, this proposal will provide me with a multimodal skill set in electrophysiology, optics, and psychophysics to probe cognitive function. These skills will help me progress towards my goal of becoming a physician scientist studying the interaction between the brain, systemic physiology, and behavior to identify biomarkers of cognitive disorders.

项目总结/摘要 我们的唤醒水平影响着几乎所有的认知和行为能力，使我们能够参与 与我们的环境。各种各样的术语被用来描述与觉醒相关的认知变化， 包括清醒、内部状态、参与和警觉。尽管这种模糊性，很明显， 是一种影响大脑活动、系统生理和行为的全球现象。行为唤醒缺陷 和全身标记物，如心率和瞳孔直径，存在于许多神经系统疾病中，包括 老年痴呆症精神分裂症和注意力缺陷障碍。为了使用这些非侵入性的系统措施 作为诊断指标，我们需要了解唤醒水平如何影响大脑活动， 神经典型的认知，并反过来导致行为的变化。这项提案的目的是调查 随着唤醒水平的波动而发生的大脑活动的变化。具体来说，我们将研究 同时测量皮质神经群体活动和脑血流动力学。我们会追踪 水平使用瞳孔直径和心率。我们首要的假设是我们可以把每分钟的兴奋 波动与神经群体活动和脑血流动力学的缓慢变化。在第一个目标中，我们将 研究内部驱动的觉醒水平的变化，发生在几个小时内和整个昼夜周期。在 第二个目标，我们将使用外部刺激来探测唤醒水平，以评估我们是否可以调节唤醒- 神经群体活动和血液动力学的相关漂移。我们记录同时发生的人口的策略 系统参数和行为背景下的活动和血流动力学变化将使我们能够 全面探索唤醒相关的变化，并整合大脑，身体和 行为这项提议的结果将有助于理解通过行为测量的唤醒偏差是如何产生的。 和全身生理学，可以作为全球大脑活动变化的生物标志物， 神经系统疾病 这一建议将在卡内基跨学科和合作的培训环境中完成 梅隆大学及其认知神经基础中心，由一个大型社区组成， 神经科学家和工程师研究认知和大脑疾病的大脑活动。下 在系统神经科学专家马特·史密斯博士和系统神经科学专家贾纳·凯纳斯托弗博士的指导下， 生物医学光学，这项建议将为我提供一个多模态的技能，在电生理学，光学， 心理物理学来探索认知功能这些技能将帮助我朝着成为一名 研究大脑，系统生理学和行为之间相互作用的医生科学家，以确定 认知障碍的生物标志物。