Substance Use Scientific Working Group

项目摘要 - 物质使用科学工作组 德克萨斯州艾滋病研究发展中心 (D-CFAR) 位于贝勒医学院 （贝勒）和德克萨斯大学休斯顿健康科学中心 (UTHealth) 和德克萨斯生物医学中心 位于圣安东尼奥的研究所 (TxBiomed)。它将建立一个物质使用科学工作组（SU- SWG）。德克萨斯州的药物使用趋势与全国相似，均呈增长趋势 近年来阿片类药物的使用以及相关的急诊科就诊和过量死亡。同样 令人担忧的是最近使用甲基苯丙胺、大麻、可卡因和酒精的趋势。物质使用 和艾滋病毒有着千丝万缕的联系。药物使用是病毒传播的一个公认的风险因素。对于 艾滋病毒感染者、药物滥用和成瘾会加速艾滋病毒的进展及其后果。 尽管物质使用对艾滋病毒有重大影响，但物质使用和艾滋病毒的交叉点一直不发达。 研究领域，特别是在美国物质使用治疗基础设施较薄弱的地区，例如德克萨斯州。 拟议的德克萨斯州 D-CFAR SU-SWG 将在三个领域培育一个强有力的研究计划，与 提出 D-CFAR 来填补这一空白：1）物质使用作为 HIV 传播的辅助因素； 2）影响 物质使用对艾滋病毒进展及其后果的影响； 3）预防艾滋病毒的新治疗方法 以及对使用药物的个人的治疗。 SU-SWG 将通过以下方式支持这些领域的研究 开发关键资源、服务、试点融资机会，并促进讨论和合作 德克萨斯州 D-CFAR 成员之间。为了实现其目标，SU-SWG 将： 1) 与拟议的核心合作 开发和支持药物滥用的核心服务，将其作为终止艾滋病毒研究重点的关键领域 优化德克萨斯州的艾滋病毒健康状况。 2) 向德克萨斯州 D-CFAR 社区通报当前和未来的情况 我们的 D-CFAR 在国内和国际上对药物滥用和艾滋病毒的交叉点进行研究。 3） 向 D-CFAR 社区通报有关物质使用的外部资助机会，提供试点项目 通过发展核心提供资助机会，并促进合作。 4) 扩展SU-SWG 向德克萨斯州其他机构的药物滥用和艾滋病毒研究人员和实习生开放会员资格。至 为了实现这些目标，D-CFAR 已在以下两个领域组建了一组成熟的早期研究人员： 将艾滋病毒和药物滥用纳入 SU-SWG，以促进这两者的交叉研究 流行病。 SU-SWG 包括与社区和当地公共卫生有深厚联系的人员 制定并领导药物使用创新计划的官员和学者 治疗。 SU-SWG 领导层与 D-CFAR 领导层合作，确定了 全面的五年行动计划、一系列活动、政策和程序以及评估指标，以确保 成功。 SU-SWG 组织的这项活动将加速消除艾滋病毒和改善人们健康的努力 德克萨斯州及其他地区的艾滋病毒感染者。

PROJECT SUMMARY - SUBSTANCE USE SCIENTIFIC WORKING GROUP The Texas Developmental Center for AIDS Research (D-CFAR) is based at Baylor College of Medicine (Baylor) and University of Texas Health Science Center at Houston (UTHealth) and the Texas Biomedical Research Institute (TxBiomed) in San Antonio. It will establish a Substance Use Scientific Working Group (SU- SWG). Substance use trends in the state of Texas are similar to the nation as a whole in showing an increase in opioid use and related emergency department visits and overdose deaths in recent years. Equally concerning are recent trends in the use of methamphetamine, marijuana, cocaine, and alcohol. Substance use and HIV are inextricably linked. Substance use is a well-established risk factor for transmission of the virus. For people living with HIV, substance use and addiction can hasten the progression of HIV and its consequences. Despite its significant impact on HIV, the intersection of substance use and HIV has been an underdeveloped research area, especially in areas of the US with weaker substance use treatment infrastructures like Texas. The proposed Texas D-CFAR SU-SWG will foster a robust research program in three areas that align with the proposed D-CFAR to fill this gap: 1) substance use as a co-factor for transmission of HIV; 2) impact of substance use on progression of HIV and its consequences; 3) novel treatment approaches for HIV prevention and treatment for individuals who use substances. The SU-SWG will support research in these areas by developing key resources, services, pilot funding opportunities, and by fostering discussions and collaborations between Texas D-CFAR members. To achieve its goals, the SU-SWG will: 1) Work with the proposed Cores and Core services to develop and support substance use as a critical area of research focus for ending HIV and optimizing HIV health in Texas. 2) Inform the Texas D-CFAR community about ongoing and future research on the intersection of substance use and HIV, both at our D-CFAR, nationally, and internationally. 3) Inform the D-CFAR community about external funding opportunities on substance use, provide pilot project funding opportunities through the Developmental Core, and catalyze collaborations. 4) Expand the SU-SWG by opening membership to substance use and HIV researchers and trainees at other Texas institutions. To achieve these aims, the D-CFAR has assembled a group of established and early stage investigators in both HIV and substance use to bring together in the SU-SWG to foster research in the intersection of these two epidemics. The SU-SWG includes persons with deep connections to the community and local public health officials as well as academicians who have developed and lead innovative programs to deliver substance use treatments. The SU-SWG leadership, in collaboration with the D-CFAR leadership, has identified a comprehensive 5-year action plan, set of activities, policies and procedures and evaluation metrics to ensure success. This activity organized by the SU-SWG will accelerate efforts to end HIV and improve the health of people with HIV in Texas and beyond.