The Impact of Natural Locomotion on Visual Processing

自然运动对视觉处理的影响

• 批准号: 10607860
• 负责人: Shelby L Sharp
• 金额: $ 4.7万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2026-09-14
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10607860
• 关键词: Anesthesia procedures; Animals; Articular Range of Motion; Attention; Behavior; Brain; Brain region; Cells; Chronic; Electrophysiology (science); Environment; Eye Movements; Future; Head; Head Movements; Implant; Investigation; Laboratories; Locomotion; Measures; Methods; Motion; Movement; Mus; Names; Neurons; Perception; Play; Process; Property; Resolution; Retina; Role; Silicon; Stream; Time; Vision; Visual; Visual Cortex; Visual System; Visual impairment; active vision; area striata; awake; cell type; experimental study; extrastriate visual cortex; gaze; in vivo; insight; neural; neural circuit; novel; response; restraint; sample fixation; sensory input; spatial integration; superior colliculus Corpora quadrigemina; treadmill; visual neuroscience; visual processing; visual receptive field; visual stimulus

PROJECT SUMMARY Vision is a dynamic process, constantly encoding visual stimuli that depend on both one's self motion and the ever changing visual scene. Past studies have suggested that locomotion modulates visual processing in numerous brain regions, contributing to modulations of gain, spatial resolution processing, and potentially attentional state, to name a few. The caveat of many of these investigations is that they were performed in restrained experimental conditions that limited animals to head-fixation and limited locomotion on a spherical treadmill. Therefore, the impact of natural, freely moving locomotion on visual processing remains unknown. We have developed methods to record visual responses during free movement. We will apply this to investigate how two key visual brain regions, primary visual cortex (V1) and superior colliculus (SC) are modulated by natural locomotion, and compare two distinct experimental in vivo electrophysiology conditions: head-fixed and natural locomotion. In Aim 1, I will use in vivo electrophysiology in V1 to analyze visual responses in both experimental conditions as well as specifically analyzing the impact of locomotion on suppressed-by-contrast cells. In Aim 2, I will use in vivo electrophysiology in SC to analyze visual responses in both experimental conditions and compare the locomotor modulation of narrow-field vertical neurons and wide- field vertical neurons. Together, these aims will determine the impact of natural locomotion on visual processing in V1 and SC on a global level and at a cell type specific level. The proposed experiments will also inform future studies aimed at dissecting the neural circuits underlying natural vision and provide experimental paradigms that may be utilized to study free moving visual neuroscience in a variety of tasks.

项目摘要 视觉是一个动态的过程，不断地对视觉刺激进行编码，这种编码既依赖于人的自我运动，也依赖于人的视觉系统。 不断变化的视觉场景。过去的研究表明，运动调节视觉处理， 许多大脑区域，有助于调节增益，空间分辨率处理，并可能 注意力状态，仅举几例。这些调查中有许多需要注意的是， 限制实验条件，限制动物头部固定和有限的运动在一个球形 跑步机因此，自然的、自由移动的运动对视觉处理的影响仍然是未知的。 我们已经开发出记录自由运动过程中视觉反应的方法。我们将把它应用于 研究两个关键的视觉大脑区域，初级视觉皮层（V1）和上级丘（SC）是如何 通过自然运动调节，并比较两种不同的实验体内电生理条件： 头部固定和自然运动。在目标1中，我将在V1中使用体内电生理学来分析视觉 在两种实验条件下的反应，以及具体分析运动对 对比度抑制细胞。在目标2中，我将在SC中使用体内电生理学来分析视觉反应， 这两个实验条件，并比较窄场垂直神经元和宽场垂直神经元的运动调制， 场垂直神经元总之，这些目标将决定自然运动对视觉的影响。 在V1和SC中在全局级别和在细胞类型特定级别进行处理。拟议的实验还将 为未来的研究提供信息，旨在解剖自然视觉的神经回路，并提供实验性的 范例，可用于研究自由移动的视觉神经科学在各种任务。