The Impact of Natural Locomotion on Visual Processing

自然运动对视觉处理的影响

• 批准号: 10607860
• 负责人: Shelby L Sharp
• 金额: $ 4.7万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2026-09-14
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10607860
• 关键词: Anesthesia procedures; Animals; Articular Range of Motion; Attention; Behavior; Brain; Brain region; Cells; Chronic; Electrophysiology (science); Environment; Eye Movements; Future; Head; Head Movements; Implant; Investigation; Laboratories; Locomotion; Measures; Methods; Motion; Movement; Mus; Names; Neurons; Perception; Play; Process; Property; Resolution; Retina; Role; Silicon; Stream; Time; Vision; Visual; Visual Cortex; Visual System; Visual impairment; active vision; area striata; awake; cell type; experimental study; extrastriate visual cortex; gaze; in vivo; insight; neural; neural circuit; novel; response; restraint; sample fixation; sensory input; spatial integration; superior colliculus Corpora quadrigemina; treadmill; visual neuroscience; visual processing; visual receptive field; visual stimulus

PROJECT SUMMARY Vision is a dynamic process, constantly encoding visual stimuli that depend on both one's self motion and the ever changing visual scene. Past studies have suggested that locomotion modulates visual processing in numerous brain regions, contributing to modulations of gain, spatial resolution processing, and potentially attentional state, to name a few. The caveat of many of these investigations is that they were performed in restrained experimental conditions that limited animals to head-fixation and limited locomotion on a spherical treadmill. Therefore, the impact of natural, freely moving locomotion on visual processing remains unknown. We have developed methods to record visual responses during free movement. We will apply this to investigate how two key visual brain regions, primary visual cortex (V1) and superior colliculus (SC) are modulated by natural locomotion, and compare two distinct experimental in vivo electrophysiology conditions: head-fixed and natural locomotion. In Aim 1, I will use in vivo electrophysiology in V1 to analyze visual responses in both experimental conditions as well as specifically analyzing the impact of locomotion on suppressed-by-contrast cells. In Aim 2, I will use in vivo electrophysiology in SC to analyze visual responses in both experimental conditions and compare the locomotor modulation of narrow-field vertical neurons and wide- field vertical neurons. Together, these aims will determine the impact of natural locomotion on visual processing in V1 and SC on a global level and at a cell type specific level. The proposed experiments will also inform future studies aimed at dissecting the neural circuits underlying natural vision and provide experimental paradigms that may be utilized to study free moving visual neuroscience in a variety of tasks.

项目总结