The Impact of Natural Locomotion on Visual Processing

自然运动对视觉处理的影响

• 批准号: 10607860
• 负责人: Shelby L Sharp
• 金额: $ 4.7万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2026-09-14
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10607860
• 关键词: Anesthesia procedures; Animals; Articular Range of Motion; Attention; Behavior; Brain; Brain region; Cells; Chronic; Electrophysiology (science); Environment; Eye Movements; Future; Head; Head Movements; Implant; Investigation; Laboratories; Locomotion; Measures; Methods; Motion; Movement; Mus; Names; Neurons; Perception; Play; Process; Property; Resolution; Retina; Role; Silicon; Stream; Time; Vision; Visual; Visual Cortex; Visual System; Visual impairment; active vision; area striata; awake; cell type; experimental study; extrastriate visual cortex; gaze; in vivo; insight; neural; neural circuit; novel; response; restraint; sample fixation; sensory input; spatial integration; superior colliculus Corpora quadrigemina; treadmill; visual neuroscience; visual processing; visual receptive field; visual stimulus

PROJECT SUMMARY Vision is a dynamic process, constantly encoding visual stimuli that depend on both one's self motion and the ever changing visual scene. Past studies have suggested that locomotion modulates visual processing in numerous brain regions, contributing to modulations of gain, spatial resolution processing, and potentially attentional state, to name a few. The caveat of many of these investigations is that they were performed in restrained experimental conditions that limited animals to head-fixation and limited locomotion on a spherical treadmill. Therefore, the impact of natural, freely moving locomotion on visual processing remains unknown. We have developed methods to record visual responses during free movement. We will apply this to investigate how two key visual brain regions, primary visual cortex (V1) and superior colliculus (SC) are modulated by natural locomotion, and compare two distinct experimental in vivo electrophysiology conditions: head-fixed and natural locomotion. In Aim 1, I will use in vivo electrophysiology in V1 to analyze visual responses in both experimental conditions as well as specifically analyzing the impact of locomotion on suppressed-by-contrast cells. In Aim 2, I will use in vivo electrophysiology in SC to analyze visual responses in both experimental conditions and compare the locomotor modulation of narrow-field vertical neurons and wide- field vertical neurons. Together, these aims will determine the impact of natural locomotion on visual processing in V1 and SC on a global level and at a cell type specific level. The proposed experiments will also inform future studies aimed at dissecting the neural circuits underlying natural vision and provide experimental paradigms that may be utilized to study free moving visual neuroscience in a variety of tasks.

项目概要 视觉是一个动态过程，不断地编码取决于人的自身运动和周围环境的视觉刺激。 不断变化的视觉场景。过去的研究表明，运动调节视觉处理 许多大脑区域，有助于增益调制、空间分辨率处理，并可能 注意力状态，仅举几例。需要注意的是，其中许多调查是在 受限的实验条件，限制动物头部固定和球形运动 跑步机。因此，自然、自由移动的运动对视觉处理的影响仍然未知。 我们开发了记录自由运动期间视觉反应的方法。我们将把它应用到 研究两个关键的视觉大脑区域，初级视觉皮层（V1）和上丘（SC）如何 通过自然运动调节，并比较两种不同的实验体内电生理条件： 头部固定且自然的运动。在目标 1 中，我将在 V1 中使用体内电生理学来分析视觉 两种实验条件下的响应以及具体分析运动对 对比抑制细胞。在目标 2 中，我将使用 SC 中的体内电生理学来分析 两种实验条件并比较窄视野垂直神经元和宽视野垂直神经元的运动调节 场垂直神经元。这些目标共同决定自然运动对视觉的影响 V1 和 SC 中的全局水平和细胞类型特定水平的处理。拟议的实验还将 为未来的研究提供信息，旨在剖析自然视觉背后的神经回路，并提供实验 可用于研究各种任务中自由移动视觉神经科学的范例。