The Impact of Natural Locomotion on Visual Processing

自然运动对视觉处理的影响

• 批准号: 10607860
• 负责人: Shelby L Sharp
• 金额: $ 4.7万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2026-09-14
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10607860
• 关键词: Anesthesia procedures; Animals; Articular Range of Motion; Attention; Behavior; Brain; Brain region; Cells; Chronic; Electrophysiology (science); Environment; Eye Movements; Future; Head; Head Movements; Implant; Investigation; Laboratories; Locomotion; Measures; Methods; Motion; Movement; Mus; Names; Neurons; Perception; Play; Process; Property; Resolution; Retina; Role; Silicon; Stream; Time; Vision; Visual; Visual Cortex; Visual System; Visual impairment; active vision; area striata; awake; cell type; experimental study; extrastriate visual cortex; gaze; in vivo; insight; neural; neural circuit; novel; response; restraint; sample fixation; sensory input; spatial integration; superior colliculus Corpora quadrigemina; treadmill; visual neuroscience; visual processing; visual receptive field; visual stimulus

PROJECT SUMMARY Vision is a dynamic process, constantly encoding visual stimuli that depend on both one's self motion and the ever changing visual scene. Past studies have suggested that locomotion modulates visual processing in numerous brain regions, contributing to modulations of gain, spatial resolution processing, and potentially attentional state, to name a few. The caveat of many of these investigations is that they were performed in restrained experimental conditions that limited animals to head-fixation and limited locomotion on a spherical treadmill. Therefore, the impact of natural, freely moving locomotion on visual processing remains unknown. We have developed methods to record visual responses during free movement. We will apply this to investigate how two key visual brain regions, primary visual cortex (V1) and superior colliculus (SC) are modulated by natural locomotion, and compare two distinct experimental in vivo electrophysiology conditions: head-fixed and natural locomotion. In Aim 1, I will use in vivo electrophysiology in V1 to analyze visual responses in both experimental conditions as well as specifically analyzing the impact of locomotion on suppressed-by-contrast cells. In Aim 2, I will use in vivo electrophysiology in SC to analyze visual responses in both experimental conditions and compare the locomotor modulation of narrow-field vertical neurons and wide- field vertical neurons. Together, these aims will determine the impact of natural locomotion on visual processing in V1 and SC on a global level and at a cell type specific level. The proposed experiments will also inform future studies aimed at dissecting the neural circuits underlying natural vision and provide experimental paradigms that may be utilized to study free moving visual neuroscience in a variety of tasks.

项目摘要 视觉是一个动态的过程，不断编码取决于一个人的自我运动和一个人的视觉刺激 不断变化的视觉场景。过去的研究表明，运动会调节视觉处理 许多大脑区域，有助于调制增益，空间分辨率处理以及可能 注意状态，仅举几例。许多调查的警告是它们是在 受限的实验条件将动物限制为固定且在球形上有限的运动有限 跑步机。因此，自然，自由移动的运动对视觉处理的影响仍然未知。 我们已经开发了在自由运动过程中记录视觉响应的方法。我们将将其应用于 研究两个关键的视觉脑区域，主要视觉皮层（V1）和上丘（SC）如何 通过自然运动调节，并比较了两个不同的体内电生理条件的实验： 头部固定和自然运动。在AIM 1中，我将在V1中使用体内电生理学来分析视觉 在实验条件下的反应以及专门分析运动对 抑制细胞抑制。在AIM 2中，我将在SC中使用体内电生理学来分析视觉反应 实验条件并比较狭窄场垂直神经元的运动调制和广泛的 现场垂直神经元。这些目标在一起将决定自然运动对视觉的影响 在全球级别和细胞类型特定级别上进行V1和SC的处理。提出的实验也将 告知未来的研究，旨在剖析自然视觉的神经回路并提供实验 可以用来研究各种任务中的自由移动视觉神经科学的范例。