Biology at birth: the role of infancy in providing the foundation for lifetime success

出生时的生物学：婴儿期为终身成功奠定基础的作用

• 批准号: 10608856
• 负责人: Rebecca Z German
• 金额: $ 1万
• 依托单位: NORTHEAST OHIO MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608856
• 关键词: Address; Adolescent; Adult; Anatomy; Area; Basic Science; Behavioral; Biological Models; Biological Sciences; Biology; Birth; Cardiovascular system; Childhood; Clinical; Clinical Research; Collaborations; Comparative Biology; Development; Discipline; Education; Educational workshop; Elements; Endocrine; Environment; Family suidae; Fertilization; Foundations; Functional disorder; Future; Goals; Guidelines; Human; Individual; Infant; Institution; Journals; Justice; Life; Manuscripts; Methodology; Mission; Modeling; Musculoskeletal; Neurologic; Organism; Output; Paper; Participant; Peer Review; Performance; Perinatal; Phenotype; Physiological; Physiology; Publishing; Rehabilitation therapy; Research; Research Personnel; Rodent; Role; Scientist; Secure; Shapes; Sheep; Societies; Specialist; System; Time; Training; Work; clinically relevant; comparative; equity, diversity, and inclusion; experience; fitness; infancy; innovation; meetings; novel; pediatrician; posters; prenatal; recruit; success; symposium

Infancy is a perilous time for any organism, with significant changes as individuals move from the maternal protected environment to the outside world. Massive anatomical, behavioral, and physiologic changes start at birth, and continue through development, with implications for adult survival and success. We have organized a symposium that addresses infancy from an integrated perspective, highlighting that this period of time in any individual’s life can shape its entire future. While neonatologists, pediatricians, and pediatric specialists across all clinical subdisciplines are broadly and deeply trained, less integration exists amongst the basic scientists who provide the substrate for clinical research and advances in treatment and rehabilitation. Our goal is to bring together basic science and clinical researchers across various life science disciplines for conversation, collaboration, and interaction across disciplinary boundaries as a way of promoting novel and innovative research at this specific moment of development. We propose three activities, which align with our Specific Aims: organize Main and Supplemental symposia on infancy at 2023 SICB meeting (SA1); a organize lunchtime workshop for participants and trainees (SA2); and publish an issue of Integrative & Comparative Biology including all platform and poster presenters, a synthetic introduction, and an overview and conclusions of the workshop (SA3). The main symposium includes three general topics: (1) how the prenatal environment shapes infant phenotype; (2) perinatal physiology and development; (3) the longitudinal impacts of infant experiences on phenotype and performance. This symposium as already been accepted for the Society of Comparative and Integrative Biology 2023 meeting, and our 11 speakers have accepted, including a commitment to submit a manuscript for peer review in early 2023 (per society and journal guidelines). We have begun recruiting speakers for our Supplemental Symposium and poster sessions (open to anyone within the society). The speakers who have committed to this symposium span multiple physiologic systems (including neurological, cardiovascular, musculoskeletal, digestive, endocrine) and multiple model species (humans, pigs, sheep, rodents). We anticipate that the discussions among individuals representing the three topic headings will galvanize interactions and cross- fertilizations. This in turn will promote new and integrative work on the both the underlying normal physiology and the specific pathophysiologies that characterize infancy.

婴儿期对任何生物体来说都是危险的时期，随着个体的移动而发生重大变化。 从母体保护的环境到外面的世界。大量的解剖学，行为学， 生理变化从出生就开始，并持续到发育，这意味着 成人的生存和成功。我们组织了一次研讨会，讨论从一个 综合视角，强调任何人生命中的这段时间都可以塑造其 整个未来。而所有临床领域的新生儿、儿科医生和儿科专家 分支学科受过广泛而深入的训练，基础科学家之间的融合较少 他们为临床研究和治疗和康复方面的进展提供了底物。我们的 目标是将不同生命科学领域的基础科学和临床研究人员聚集在一起 跨学科边界的对话、协作和交互的学科 在这个特定的发展时刻，推动新奇和创新研究的方式。我们 提出与我们的具体目标一致的三项活动：组织主要活动和补充活动 在2023年SICB会议上举办关于婴儿期的专题讨论会(SA1)；为 参与者和受训者(SA2)；出版一期《综合与比较生物学》 包括所有平台和海报演示者、综合介绍以及概述和 研讨会结论(SA3)。主要研讨会包括三个一般性主题：(1)如何 产前环境塑造婴儿表型；(2)围产期生理和发育；(3) 婴儿经历对表型和表现的纵向影响。 本研讨会已被比较与综合学会接受 生物学2023会议，我们的11位演讲者已经接受，包括承诺提交 2023年初供同行评审的手稿(根据学会和期刊指南)。我们已经开始了 为我们的补充研讨会和海报会议招募演讲者(对以下网站的任何人开放 社会)。致力于这次研讨会的演讲者跨越了多个生理学领域 系统(包括神经、心血管、肌肉骨骼、消化、内分泌)和 多种模式物种(人、猪、羊、啮齿动物)。我们预计这次讨论 代表三个主题标题的个人之间将激发互动和交叉 受精。这反过来将促进关于这两个基本常态的新的和综合的工作 婴儿期的生理学和特殊的病理生理学。