Cardiovascular Health Trajectories from Birth Thru Adolescence in A Diverse Cohort of Children

不同儿童群体从出生到青春期的心血管健康轨迹

• 批准号: 10609076
• 负责人: NORRINA Bai ALLEN
• 金额: $ 67.81万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609076
• 关键词: Acceleration; Address; Adolescence; Adult; Age; Age Years; Behavior; Behavior assessment; Behavioral; Birth; Blood Pressure; Body mass index; Cardiovascular Diseases; Chicago; Child; Childhood; Cholesterol; Chronic Disease; Cities; Clinical; Data; Data Collection; Dementia; Development; Diabetes Mellitus; Diet; Disparity; Dyslipidemias; Electronic Health Record; Enrollment; Environment; Ethnic Origin; Family; Family health status; Future; Generations; Glucose; Goals; Grant; Growth; Guide prevention; Health; Health Status; Hypertension; Incidence; Individual; Intervention; Life; Life Cycle Stages; Life Style; Link; Longevity; Longitudinal Studies; Malignant Neoplasms; Measurement; Measures; Mental Depression; National Heart, Lung, and Blood Institute; Neighborhoods; Neuropsychology; Obesity; Outcome; Parents; Participant; Physical activity; Population; Prevalence; Prevention; Prevention strategy; Questionnaires; Race; Recording of previous events; Research Design; Resources; Risk Factors; Smoking; Social Environment; Social support; Socioeconomic Status; Surveys; Technology; Time; Translating; Youth; burden of illness; cardiovascular health; cardiovascular risk factor; clinical care; clinical phenotype; clinical practice; cohort; contextual factors; critical period; disorder risk; early childhood; electronic health record system; epidemiology study; follow-up; healthspan; high risk; infancy; innovation; interest; lifestyle data; novel; obesity in children; preservation; prevent; rate of change; recruit; resilience; resilience factor; skills; stem; tool; young adult

Abstract The overarching goal of this proposal is to identify CVH trajectories from birth through age 20 among a diverse cohort of 7,000 children and their families who already have clinical phenotyping to which we will add detailed behavioral data and follow them longitudinally. Using an innovative study design for a pragmatic cohort utilizing technology-enabled data collection we will recruit a diverse cohort of children from a city-wide electronic health record (EHR) system in Chicago. Parents/children will complete a developmentally appropriate and clinically feasible set of online surveys and questionnaires to assess behaviors and lifestyles that will be linked with their EHR data already being used in a prior study. After two years we will re-assess each child's CVH. Our innovative accelerated longitudinal study design (ALD) will allow us to define CVH and create trajectories for a diverse group of children from birth through age 20 all within the 5 years of this grant. These trajectories will then be used to create a novel “CVH growth curve” ready for use in clinical practice. Our team has the unique expertise to complete this study including already having the EHR data for children across Chicago, expertise in cohort recruitment and retention as well as inclusion of leading experts in studying CVH among children. The findings from this study will be critical in targeting prevention strategies to high-risk children and critical periods during the life course in order to prevent the loss of CVH in childhood and preserve and promote CVH across the life course. We will develop a clinical tool, CVH growth curves, that can be directly translated into clinical care and will inform prevention efforts. Our specific aims are as follows: Specific Aims: 1. Identify CVH trajectories from birth to young adulthood within a diverse cohort of participants (n=7,000) across the city of Chicago 2. Identify predictors of CVH trajectories from birth to young adulthood within a diverse cohort of participants including a broad range of markers of resilience and vulnerability 3. Develop an accurate and generalizable Cardiovascular Health Growth Curve for use in clinical care to target prevention to children at high risk of declining CVH and subsequent CVD

摘要 该提案的总体目标是确定从出生到20岁的CVH轨迹， 我们将对7,000名已经有临床表型的儿童及其家庭进行详细的分析， 行为数据并纵向跟踪它们。使用创新的研究设计为一个务实的队列， 技术支持的数据收集我们将从全市范围的电子健康中心招募一批多样化的儿童， 芝加哥的电子健康记录（EHR）系统。父母/孩子将完成一个适合发育和临床的 一套可行的在线调查和问卷，以评估行为和生活方式，将与他们的 EHR数据已经在之前的研究中使用。两年后，我们将重新评估每个孩子的CVH。我们 创新的加速纵向研究设计（ALD）将使我们能够定义CVH，并为 从出生到20岁的各种儿童群体，所有这些儿童都是在领取该补助金的5年内。这些轨迹将 然后用于创建准备用于临床实践的新的“CVH生长曲线”。我们的团队拥有 独特的专业知识来完成这项研究，包括已经拥有芝加哥儿童的电子健康记录数据， 在队列招募和保留方面的专业知识，以及包括研究CVH的领先专家， 孩子这项研究的结果对于针对高危儿童的预防战略至关重要， 在生命过程中的关键时期，以防止儿童期CVH的丧失， 在整个生命过程中促进CVH。我们将开发一种临床工具，CVH生长曲线，可以直接 转化为临床护理，并将为预防工作提供信息。我们的具体目标如下： 具体目标： 1.在不同的参与者队列中确定从出生到青年期的CVH轨迹 （n= 7，000）整个芝加哥市 2.在一个不同的队列中确定从出生到青年期CVH轨迹的预测因子， 与会者包括一系列广泛的复原力和脆弱性标志 3.制定一个准确和可推广的心血管健康成长曲线，用于临床护理 针对CVH下降和随后CVD的高风险儿童进行预防