Childhood Asthma in Urban Settings Clinical Research Network - Leadership Center
城市环境中的儿童哮喘临床研究网络 - 领导中心
基本信息
- 批准号:10608089
- 负责人:
- 金额:$ 676.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-12 至 2028-03-31
- 项目状态:未结题
- 来源:
- 关键词:17 year oldAccident and Emergency departmentAddressAffectAirAllergensAllergicAsthmaBacteriaBirthCaringCellsChildChildhood AsthmaClinical ResearchClinical TrialsDevelopmentDictyopteraDietary InterventionDiseaseDisease ProgressionDouble-Blind MethodEmergency department visitEnrollmentEnvironmental Risk FactorEvaluationEventExposure toExtrinsic asthmaFamily history ofGenetic TranscriptionGoalsGuidelinesHealthcareHospitalizationHospitalsHypersensitivityImmuneImmunotherapyInfantInfection preventionInflammationInterventionIntervention TrialLeadershipLifeMicrobeModificationMolecularMorbidity - disease rateNational Institute of Allergy and Infectious DiseaseObservational StudyOutpatientsPathogenesisPathway interactionsPatientsPatternPhasePhenotypePlacebo ControlPollutionPreventionProtocols documentationRecurrenceResearchRespiratory DiseaseRespiratory MucosaRhinitisRiskRisk FactorsRoleSelf CareSeveritiesStressSupplementationTestingUnited StatesUrban CommunityVisionWheezingairway immune responseasthma exacerbationcare burdencommon treatmentdisorder controldisorder preventiondouble-blind placebo controlled trialeffective therapyexpectationgut microbiomehigh riskimmunoregulationimprovedinfancyinsightlongitudinal analysislower income familiesmicrobialmicrobial colonizationmicrobiomemultiple omicsnovelnovel strategiesomalizumabpreventprogramsrespiratory healthsubcutaneousurban childrenurban setting
项目摘要
PROJECT SUMMARY/ABSTRACT
The overall goals of our Childhood Asthma in Urban Settings (CAUSE)-Leadership Center proposal are to
provide administrative leadership and support to develop and conduct collaborative research to address high
priority unmet needs for childhood asthma in urban communities, including: a) developing strategies to prevent
asthma, b) improving treatment and inhibiting progression, c) reducing severe exacerbations, and d) defining
endotypes of respiratory health and disease. Four hypotheses are proposed to accomplish these goals. First,
supplementation with immune modulating bacteria in infancy will prevent the early life perturbations in the gut
microbiome that have been associated with risk for the development of allergic sensitization and asthma, and
will promote airway mucosal immune development. Second, given the importance of cockroach (CR) allergy
and exposure to asthma morbidity in urban children, CR immunotherapy will improve asthma control and
reduce disease progression. Third, we propose that transcriptional analysis of airway cells will define T2-low
mechanisms that contribute to both non-atopic and atopic asthma and provide new insights into treatment.
Finally, multi-omics evaluation of airway cells and secretions obtained during severe exacerbations leading to
ED visits and hospitalizations will reveal novel mechanistic pathways to inform improved treatment and
prevention. We propose five protocols to test these hypotheses:
1. Urban Environment and Childhood Asthma study (URECA)
2. Effects of a Microbial Supplement (STMC-103H) on Microbial Colonization and Immune Development
3. Cockroach (CR) Immunotherapy (IT) in Urban Children with Moderate-Severe Asthma Protected by
Omalizumab
4. Pathogenesis and Mechanisms of T2-low (Non-Atopic) Asthma
5. Severe Asthma Exacerbations in the Emergency Department (ED) and Hospital: Identifying Targets for
Prevention and Treatment
It is our expectation that our proposed CAUSE research program will provide critical information needed to
recognize asthma phenotypes and endotypes in urban children, improve treatment of asthma and establish
direction for prevention. Collectively, these studies will continue the rigorous programmatic approach of the
NIAID Asthma Networks towards achieving the long-term goals of disease modification and prevention of
disease in high-risk children of low-income families living in urban communities.
项目总结/摘要
我们的城市儿童哮喘(原因)-领导中心提案的总体目标是
提供行政领导和支持,以发展和开展合作研究,以解决高
城市社区儿童哮喘的优先未满足需求,包括:a)制定预防战略,
哮喘,B)改善治疗并抑制进展,c)减少严重恶化,和d)定义
呼吸系统健康和疾病的内在型。为了实现这些目标,提出了四个假设。第一、
在婴儿期补充免疫调节细菌将防止肠道中的早期生命扰动
与过敏性致敏和哮喘发生风险相关的微生物组,以及
会促进气道黏膜免疫发育。其次,鉴于蟑螂(CR)过敏的重要性,
和暴露于城市儿童哮喘发病率,CR免疫治疗将改善哮喘控制,
减少疾病进展。第三,我们提出气道细胞的转录分析将定义T2-低
这些研究有助于阐明非特应性和特应性哮喘的发病机制,并为治疗提供新的见解。
最后,在严重急性发作期间获得的气道细胞和分泌物的多组学评估导致
艾德就诊和住院将揭示新的机制途径,以告知改善治疗,
预防我们提出了五个协议来测试这些假设:
1.城市环境与儿童哮喘研究(URECA)
2.微生物补充剂(STMC-103 H)对微生物定植和免疫发育的影响
3.蟑螂(CR)免疫治疗(IT)在城市中重度哮喘儿童中的应用
Omalizumab
4.低T2(非特应性)哮喘的发病机制
5.急诊科(艾德)和医院中的重度哮喘急性发作:
预防和治疗
我们期望我们提议的CAUSE研究计划将提供所需的关键信息,
认识城市儿童的哮喘表型和内在型,改善哮喘治疗,
预防的方向。总体而言,这些研究将继续采用联合国的严格方案办法,
NIAID哮喘网络致力于实现疾病改善和预防的长期目标,
城市社区低收入家庭高危儿童的疾病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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James E. Gern其他文献
Cockroach-induced <em>IL9</em>, <em>IL13</em>, and <em>IL31</em> expression and the development of allergic asthma in urban children
- DOI:
10.1016/j.jaci.2021.01.022 - 发表时间:
2021-05-01 - 期刊:
- 影响因子:
- 作者:
Petra LeBeau;Alexandre Lockhart;Alkis Togias;Megan T. Sandel;Jessica D. Gereige;Leonard Bacharier;Stephanie Lovinsky-Desir;Robert A. Wood;Robert James;William W. Busse;James E. Gern;Matthew C. Altman; National Institute of Allergy and Infectious Diseases-Sponsored Inner-City Asthma Consortium - 通讯作者:
National Institute of Allergy and Infectious Diseases-Sponsored Inner-City Asthma Consortium
Rhinoconjunctivitis symptoms in children and adolescents with asthma: Longitudinal clustering analysis
哮喘儿童和青少年的鼻结膜炎症状:纵向聚类分析
- DOI:
10.1016/j.jaci.2024.12.1084 - 发表时间:
2025-05-01 - 期刊:
- 影响因子:11.200
- 作者:
Alkis Togias;Peter J. Gergen;Andrew H. Liu;Haejin Kim;Robert A. Wood;George T. O’Connor;Melanie Makhija;Gurjit K. Khurana Hershey;Carolyn M. Kercsmar;Rebecca S. Gruchalla;Carin Lamm;Leonard B. Bacharier;Shilpa J. Patel;James E. Gern;Daniel J. Jackson;Cynthia M. Visness;Agustin Calatroni;William W. Busse - 通讯作者:
William W. Busse
Immunogenicity of 50-Valent Rhinovirus Vaccine
- DOI:
10.1016/j.jaci.2016.12.899 - 发表时间:
2017-02-01 - 期刊:
- 影响因子:
- 作者:
Sujin Lee;Minh Trang Nguyen;Michael G. Currier;Joe B. Jenkins;Elizabeth A. Strobert;Adriana E. Kajon;Ranjna Madan-Lala;Yury A. Bochkov;James E. Gern;Krishnendu Roy;Xiaoyan Lu;Dean D. Erdman;Paul Spearman;Martin L. Moore - 通讯作者:
Martin L. Moore
emRothia/em from the Human Nose Inhibit emMoraxella catarrhalis/em Colonization with a Secreted Peptidoglycan Endopeptidase
来自人鼻的罗思氏菌通过分泌肽聚糖内肽酶抑制卡他莫拉菌定植
- DOI:
10.1128/mbio.00464-23 - 发表时间:
2023-04-10 - 期刊:
- 影响因子:4.700
- 作者:
Reed M. Stubbendieck;Eishika Dissanayake;Peter M. Burnham;Susan E. Zelasko;Mia I. Temkin;Sydney S. Wisdorf;Rose F. Vrtis;James E. Gern;Cameron R. Currie - 通讯作者:
Cameron R. Currie
Early-life upper airway microbiota are associated with decreased lower respiratory tract infections
生命早期的上呼吸道微生物群与下呼吸道感染的减少有关。
- DOI:
10.1016/j.jaci.2024.11.008 - 发表时间:
2025-02-01 - 期刊:
- 影响因子:11.200
- 作者:
Susan Zelasko;Mary Hannah Swaney;Shelby Sandstrom;Kristine E. Lee;Jonah Dixon;Colleen Riley;Lauren Watson;Jared J. Godfrey;Naomi Ledrowski;Federico Rey;Nasia Safdar;Christine M. Seroogy;James E. Gern;Lindsay Kalan;Cameron Currie - 通讯作者:
Cameron Currie
James E. Gern的其他文献
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{{ truncateString('James E. Gern', 18)}}的其他基金
Childhood Asthma in Urban Settings Clinical Research Network - Leadership Center
城市环境中的儿童哮喘临床研究网络 - 领导中心
- 批准号:
10209602 - 财政年份:2021
- 资助金额:
$ 676.71万 - 项目类别:
Childhood Asthma in Urban Settings Clinical Research Network - Leadership Center
城市环境中的儿童哮喘临床研究网络 - 领导中心
- 批准号:
10391566 - 财政年份:2021
- 资助金额:
$ 676.71万 - 项目类别:
Identifying Coronavirus B-cell Epitopes Associated with COVID-19 Illness Severity
识别与 COVID-19 疾病严重程度相关的冠状病毒 B 细胞表位
- 批准号:
10170660 - 财政年份:2020
- 资助金额:
$ 676.71万 - 项目类别:
Human epidemiology and response to SARS-CoV-2 (HEROS)
人类流行病学和对 SARS-CoV-2 的反应 (HEROS)
- 批准号:
10230381 - 财政年份:2020
- 资助金额:
$ 676.71万 - 项目类别:
Viral and Environmental Determinants of Rhinovirus Illness Severity
鼻病毒疾病严重程度的病毒和环境决定因素
- 批准号:
10397758 - 财政年份:2020
- 资助金额:
$ 676.71万 - 项目类别:
Viral and Environmental Determinants of Rhinovirus Illness Severity
鼻病毒疾病严重程度的病毒和环境决定因素
- 批准号:
10265713 - 财政年份:2020
- 资助金额:
$ 676.71万 - 项目类别:
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-Up
威斯康星州婴儿研究队列 (WISC) ECHO 儿科随访
- 批准号:
10744843 - 财政年份:2016
- 资助金额:
$ 676.71万 - 项目类别:
Children's Respiratory and Environmental Workgroup (CREW)
儿童呼吸和环境工作组 (CREW)
- 批准号:
9262672 - 财政年份:2016
- 资助金额:
$ 676.71万 - 项目类别:
Children's Respiratory and Environmental Workgroup (CREW)
儿童呼吸和环境工作组 (CREW)
- 批准号:
10011947 - 财政年份:2016
- 资助金额:
$ 676.71万 - 项目类别:
Children's Respiratory and Environmental Workgroup (CREW)
儿童呼吸和环境工作组 (CREW)
- 批准号:
10475195 - 财政年份:2016
- 资助金额:
$ 676.71万 - 项目类别: