Childhood Asthma in Urban Settings Clinical Research Network - Leadership Center

城市环境中的儿童哮喘临床研究网络 - 领导中心

基本信息

  • 批准号:
    10608089
  • 负责人:
  • 金额:
    $ 676.71万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-04-12 至 2028-03-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT The overall goals of our Childhood Asthma in Urban Settings (CAUSE)-Leadership Center proposal are to provide administrative leadership and support to develop and conduct collaborative research to address high priority unmet needs for childhood asthma in urban communities, including: a) developing strategies to prevent asthma, b) improving treatment and inhibiting progression, c) reducing severe exacerbations, and d) defining endotypes of respiratory health and disease. Four hypotheses are proposed to accomplish these goals. First, supplementation with immune modulating bacteria in infancy will prevent the early life perturbations in the gut microbiome that have been associated with risk for the development of allergic sensitization and asthma, and will promote airway mucosal immune development. Second, given the importance of cockroach (CR) allergy and exposure to asthma morbidity in urban children, CR immunotherapy will improve asthma control and reduce disease progression. Third, we propose that transcriptional analysis of airway cells will define T2-low mechanisms that contribute to both non-atopic and atopic asthma and provide new insights into treatment. Finally, multi-omics evaluation of airway cells and secretions obtained during severe exacerbations leading to ED visits and hospitalizations will reveal novel mechanistic pathways to inform improved treatment and prevention. We propose five protocols to test these hypotheses: 1. Urban Environment and Childhood Asthma study (URECA) 2. Effects of a Microbial Supplement (STMC-103H) on Microbial Colonization and Immune Development 3. Cockroach (CR) Immunotherapy (IT) in Urban Children with Moderate-Severe Asthma Protected by Omalizumab 4. Pathogenesis and Mechanisms of T2-low (Non-Atopic) Asthma 5. Severe Asthma Exacerbations in the Emergency Department (ED) and Hospital: Identifying Targets for Prevention and Treatment It is our expectation that our proposed CAUSE research program will provide critical information needed to recognize asthma phenotypes and endotypes in urban children, improve treatment of asthma and establish direction for prevention. Collectively, these studies will continue the rigorous programmatic approach of the NIAID Asthma Networks towards achieving the long-term goals of disease modification and prevention of disease in high-risk children of low-income families living in urban communities.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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James E. Gern其他文献

Cockroach-induced <em>IL9</em>, <em>IL13</em>, and <em>IL31</em> expression and the development of allergic asthma in urban children
  • DOI:
    10.1016/j.jaci.2021.01.022
  • 发表时间:
    2021-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    Petra LeBeau;Alexandre Lockhart;Alkis Togias;Megan T. Sandel;Jessica D. Gereige;Leonard Bacharier;Stephanie Lovinsky-Desir;Robert A. Wood;Robert James;William W. Busse;James E. Gern;Matthew C. Altman; National Institute of Allergy and Infectious Diseases-Sponsored Inner-City Asthma Consortium
  • 通讯作者:
    National Institute of Allergy and Infectious Diseases-Sponsored Inner-City Asthma Consortium
Immunogenicity of 50-Valent Rhinovirus Vaccine
  • DOI:
    10.1016/j.jaci.2016.12.899
  • 发表时间:
    2017-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Sujin Lee;Minh Trang Nguyen;Michael G. Currier;Joe B. Jenkins;Elizabeth A. Strobert;Adriana E. Kajon;Ranjna Madan-Lala;Yury A. Bochkov;James E. Gern;Krishnendu Roy;Xiaoyan Lu;Dean D. Erdman;Paul Spearman;Martin L. Moore
  • 通讯作者:
    Martin L. Moore
Rhinoconjunctivitis symptoms in children and adolescents with asthma: Longitudinal clustering analysis
哮喘儿童和青少年的鼻结膜炎症状:纵向聚类分析
  • DOI:
    10.1016/j.jaci.2024.12.1084
  • 发表时间:
    2025-05-01
  • 期刊:
  • 影响因子:
    11.200
  • 作者:
    Alkis Togias;Peter J. Gergen;Andrew H. Liu;Haejin Kim;Robert A. Wood;George T. O’Connor;Melanie Makhija;Gurjit K. Khurana Hershey;Carolyn M. Kercsmar;Rebecca S. Gruchalla;Carin Lamm;Leonard B. Bacharier;Shilpa J. Patel;James E. Gern;Daniel J. Jackson;Cynthia M. Visness;Agustin Calatroni;William W. Busse
  • 通讯作者:
    William W. Busse
Early-life upper airway microbiota are associated with decreased lower respiratory tract infections
生命早期的上呼吸道微生物群与下呼吸道感染的减少有关。
  • DOI:
    10.1016/j.jaci.2024.11.008
  • 发表时间:
    2025-02-01
  • 期刊:
  • 影响因子:
    11.200
  • 作者:
    Susan Zelasko;Mary Hannah Swaney;Shelby Sandstrom;Kristine E. Lee;Jonah Dixon;Colleen Riley;Lauren Watson;Jared J. Godfrey;Naomi Ledrowski;Federico Rey;Nasia Safdar;Christine M. Seroogy;James E. Gern;Lindsay Kalan;Cameron Currie
  • 通讯作者:
    Cameron Currie
emRothia/em from the Human Nose Inhibit emMoraxella catarrhalis/em Colonization with a Secreted Peptidoglycan Endopeptidase
来自人鼻的罗思氏菌通过分泌肽聚糖内肽酶抑制卡他莫拉菌定植
  • DOI:
    10.1128/mbio.00464-23
  • 发表时间:
    2023-04-10
  • 期刊:
  • 影响因子:
    4.700
  • 作者:
    Reed M. Stubbendieck;Eishika Dissanayake;Peter M. Burnham;Susan E. Zelasko;Mia I. Temkin;Sydney S. Wisdorf;Rose F. Vrtis;James E. Gern;Cameron R. Currie
  • 通讯作者:
    Cameron R. Currie

James E. Gern的其他文献

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{{ truncateString('James E. Gern', 18)}}的其他基金

Childhood Asthma in Urban Settings Clinical Research Network - Leadership Center
城市环境中的儿童哮喘临床研究网络 - 领导中心
  • 批准号:
    10209602
  • 财政年份:
    2021
  • 资助金额:
    $ 676.71万
  • 项目类别:
Childhood Asthma in Urban Settings Clinical Research Network - Leadership Center
城市环境中的儿童哮喘临床研究网络 - 领导中心
  • 批准号:
    10391566
  • 财政年份:
    2021
  • 资助金额:
    $ 676.71万
  • 项目类别:
Identifying Coronavirus B-cell Epitopes Associated with COVID-19 Illness Severity
识别与 COVID-19 疾病严重程度相关的冠状病毒 B 细胞表位
  • 批准号:
    10170660
  • 财政年份:
    2020
  • 资助金额:
    $ 676.71万
  • 项目类别:
Human epidemiology and response to SARS-CoV-2 (HEROS)
人类流行病学和对 SARS-CoV-2 的反应 (HEROS)
  • 批准号:
    10230381
  • 财政年份:
    2020
  • 资助金额:
    $ 676.71万
  • 项目类别:
Viral and Environmental Determinants of Rhinovirus Illness Severity
鼻病毒疾病严重程度的病毒和环境决定因素
  • 批准号:
    10397758
  • 财政年份:
    2020
  • 资助金额:
    $ 676.71万
  • 项目类别:
Viral and Environmental Determinants of Rhinovirus Illness Severity
鼻病毒疾病严重程度的病毒和环境决定因素
  • 批准号:
    10265713
  • 财政年份:
    2020
  • 资助金额:
    $ 676.71万
  • 项目类别:
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-Up
威斯康星州婴儿研究队列 (WISC) ECHO 儿科随访
  • 批准号:
    10744843
  • 财政年份:
    2016
  • 资助金额:
    $ 676.71万
  • 项目类别:
Children's Respiratory and Environmental Workgroup (CREW)
儿童呼吸和环境工作组 (CREW)
  • 批准号:
    9262672
  • 财政年份:
    2016
  • 资助金额:
    $ 676.71万
  • 项目类别:
Children's Respiratory and Environmental Workgroup (CREW)
儿童呼吸和环境工作组 (CREW)
  • 批准号:
    10011947
  • 财政年份:
    2016
  • 资助金额:
    $ 676.71万
  • 项目类别:
Children's Respiratory and Environmental Workgroup (CREW)
儿童呼吸和环境工作组 (CREW)
  • 批准号:
    10475195
  • 财政年份:
    2016
  • 资助金额:
    $ 676.71万
  • 项目类别:
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