Advances in Sleep and Circadian Science

睡眠和昼夜节律科学的进展

• 批准号: 10611738
• 负责人: JAMIE M ZEITZER
• 金额: $ 2.4万
• 依托单位: SLEEP RESEARCH SOCIETY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-08 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10611738
• 关键词: Aging; Alzheimer' s Disease; Award; Behavioral; Blinded; Charge; Circadian Rhythms; Clinical; Cognition; Dedications; Development; Doctor of Philosophy; Eligibility Determination; Epigenetic Process; Ethnic Origin; Female; Florida; Functional disorder; Future; Genetic; Goals; Health; Immune; Individual; Institution; Knowledge; Link; Location; Longevity; Medicine; Metabolic; Metabolism; Mission; Molecular; Motor; National Heart, Lung, and Blood Institute; National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Neurologic; Nobel Prize; Output; Physical Performance; Physiological; Physiology; Principal Investigator; Process; Race; Regulation; Research; Research Personnel; Rosemary; Schedule; Science; Scientific Advances and Accomplishments; Scientist; Sensory; Sleep; Societies; Travel; Underrepresented Populations; base; career; career development; circadian; experience; immune function; meetings; microbiome; neuropsychiatry; posters; sex; social; success; symposium; translational pipeline; transmission process

Abstract The Sleep Research Society (SRS) is dedicated to promoting and advancing the scientific understanding of sleep and circadian rhythms across the translational spectrum, from their molecular regulation across species, to their cross-generational transmission through genetic, epigenetic, cultural, and social forces, to their impact on health and functioning. Inexorably linked, sleep and circadian rhythms entrain and sustain physiological and behavioral processes critical to survival, such as immune, psychiatric/neurologic, metabolic, and motor functions. In 2017, circadian biologists Michael Young, Michael Rosbash, and Jeffrey Hall were awarded the Nobel Prize in Physiology or Medicine for their discoveries that propelled our understanding of the molecular mechanisms controlling circadian rhythms. Advances in the molecular underpinnings of circadian rhythms have, in turn, informed our understanding of the cellular and molecular mechanisms of sleep. Yet, despite the physiological and behavioral links between sleep and circadian rhythms, the fields of sleep and circadian science have evolved somewhat independently, limiting their reach and scope. The SRS seeks to redress this issue by organizing a unique transdisciplinary sleep and circadian science conference to promote interdisciplinary cross-talk, extensive discussion of cutting-edge science, identification of gaps in knowledge and opportunities to catalyze transdisciplinary research, and specialized programming for trainees and early stage investigators, who represent the future of this important transdisciplinary field.

摘要 睡眠研究会(SRS)致力于促进和推进睡眠科学 通过翻译光谱理解睡眠和昼夜节律，从他们的 跨物种的分子调控，通过遗传的跨代传播， 表观遗传、文化和社会力量对健康和功能的影响。无情地联系在一起， 睡眠和昼夜节律牵涉并维持关键的生理和行为过程 对生存的影响，如免疫、精神/神经、代谢和运动功能。2017年， 生物学家迈克尔·杨、迈克尔·罗斯巴什和杰弗里·霍尔被授予诺贝尔奖 生理学或医学奖，表彰他们的发现推动了我们对 控制昼夜节律的分子机制。分子基础研究进展 昼夜节律的变化反过来又促进了我们对细胞和分子的理解。 睡眠机制。然而，尽管睡眠和行为之间存在生理和行为上的联系 昼夜节律，睡眠和昼夜节律科学的领域都有了一些进展 独立，限制了它们的覆盖范围和范围。SRS试图通过组织以下方式解决这个问题 一个独特的跨学科睡眠和昼夜科学会议，以促进跨学科 交叉对话、对尖端科学的广泛讨论、确定知识差距和 为受训者提供促进跨学科研究和专业规划的机会 以及早期调查人员，他们代表着这一重要跨学科领域的未来。