Hybrid Closed Loop Insulin Pump use in Poorly Controlled Type 1 Diabetes

混合闭环胰岛素泵在控制不佳的 1 型糖尿病中的应用

• 批准号: 10611478
• 负责人: Estelle Marla Everett
• 金额: $ 20.17万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-19 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10611478
• 关键词: Achievement; Address; Adult; Algorithms; American; Area; Award; Blood Glucose Self-Monitoring; Blood Vessels; Bypass; Calibration; Caring; Cessation of life; Clinical; Clinical Trials; Clinical Trials Design; Complex; Computerized Medical Record; Continuous Glucose Monitor; County; Data; Data Analyses; Data Collection; Development; Diabetes Mellitus; Disparity; Documentation; Dose; Education; Electronic Health Record; Endocrinologist; Enrollment; Evaluation; Exclusion; Fingers; Funding; Future; Glycosylated hemoglobin A; Goals; Guidelines; Health Services; Health system; Healthcare Systems; Hybrids; Injections; Insulin; Insulin Infusion Systems; Insulin-Dependent Diabetes Mellitus; Intervention; K-Series Research Career Programs; Knowledge; Los Angeles; Medical; Mentored Patient-Oriented Research Career Development Award; Methods; National Institute of Diabetes and Digestive and Kidney Diseases; Natural Language Processing; Outcome; Paper; Patient Care; Patients; Population; Positioning Attribute; Principal Investigator; Publishing; Pump; Quality of life; Randomized, Controlled Trials; Recommendation; Research; Research Personnel; Research Training; Risk; Self Management; Series; Socioeconomic Status; System; Technology; Time; Training; Vulnerable Populations; access disparities; basal insulin; care burden; clinical care; design; diabetes control; diabetes management; effectiveness evaluation; efficacy evaluation; ethnic minority; experience; glucose monitor; glycemic control; health care settings; high risk; high risk population; improved; improved outcome; interest; low health literacy; low socioeconomic status; monitoring device; new technology; novel; patient oriented; patient population; racial minority; real time monitoring; safety net; satisfaction; sensor; skills

Project Summary/Abstract This career development award will establish me (Dr. Estelle Everett MD, MHS), as an independent investigator focused on evaluating and addressing disparities in management and outcomes in vulnerable patient populations with type 1 diabetes (T1D). This K23 award will provide the support I need to develop expertise in three key areas: 1) EMR-based retrospective data analysis and natural language processing (NLP) methods, 2) clinical trial design, implementation, and analysis, and 3) qualitative study development, data collection and analysis. After receiving my medical and research training in at Johns Hopkins and publishing a series of general diabetes papers, my research interests have increasingly focused on patients with poorly controlled T1D. I am committed to improving care and outcomes in this complex group of patients whose long duration of T1D increases their risk of developing complications early in their lifetime. Although diabetes technology has revolutionized T1D management, disparities in technology access are evident among racial-ethnic minorities, patients with lower socioeconomic status and those with poorly controlled T1D. To help address these gaps, it is critical to leverage electronic health record (EHR) data to readily identify patients experiencing diabetes technology disparities. In order to examine whether diabetes technology can reduce diabetes care burdens and enhance outcomes among some of highest need patients, we need to expand diabetes technology clinical trials beyond the very select populations included thus far (ie., mostly White, higher SES). Therefore, I propose to: 1) To develop and validate a novel electronic medical record (EMR) algorithm using natural language processing (NLP) to identify insulin pump and/or CGM use among patients with type 1 diabetes; 2) To perform a pilot RCT of hybrid closed-loop insulin pump therapy (HCL) in 40 diverse adult patients with poorly controlled T1D (HbA1c >9%) from the largest academic and safety net health systems in the Los Angeles region; and 3) To identify facilitators and barriers of effective use of closed loop insulin pump therapy in patients with poorly controlled T1D. Findings from Aim 1 can be readily used to support T1D care in other settings and findings from Aims 2 and 3 will also be used to inform a future RCT as part of a future NIDDK R01 application. This K23 award will provide the support to complete these aims and my educational objectives, which will provide me with the training and skills needed to become a national leader and independent clinician-investigator aimed to improve outcomes in vulnerable populations with T1D.

项目总结/文摘