Integrative analysis of human placental epi/genome in relation to fetal growth

人类胎盘表观/基因组与胎儿生长相关的综合分析

• 批准号: 10611359
• 负责人: Corina Lesseur Perez
• 金额: $ 24.4万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10611359
• 关键词: Accounting; Address; Adult; Affect; Big Data; Bioinformatics; Biological; Biological Markers; Birth; Birth Weight; Blood specimen; Catalogs; Cell Separation; Cells; Child Health; Cohort Studies; Complex; Computational Biology; DNA; DNA Methylation; Data; Development; Disease; Elderly; Environment; Epidemiologist; Epidemiology; Face; Fetal Growth; Fetal health; Future; Gene Expression; Genome; Genomics; Genotype; Goals; Health; Heterogeneity; Human; Individual; Individual Differences; Inherited; Knowledge; Lasers; Life; Link; Longevity; Malignant Neoplasms; Maps; Maternal Health; Mentors; Mesenchymal; Methylation; Molecular; Molecular Epidemiology; Outcome; Pathology; Phase; Phenotype; Placenta; Placental Biology; Population Study; Proxy; Research; Research Personnel; Resources; Rhode Island; Sampling; Single Nucleotide Polymorphism; Syncytiotrophoblast; Tissue Sample; Tissues; Training; Work; cell type; cohort; cytotrophoblast; disorder prevention; disorder risk; early life exposure; empowerment; epidemiologic data; epidemiology study; experience; fetal; fetal programming; genome wide association study; genome-wide; genomic data; genomic locus; genomic profiles; improved; in utero; insight; interest; intrauterine environment; methylome; molecular subtypes; multiple omics; next generation; offspring; population based; risk prediction; trait; transcriptome; trophoblast

The goal of this proposal is to integrate multi-scale epi/genomic placental molecular features and relate this to fetal growth to provide mechanism insight into the contribution of the placenta to the Developmental Origins of Health and Disease (DOHaD). I am a molecular epidemiologist with a primary research interest in understanding inter-individual differences in disease risk and how early-life exposures can influence these differences. In the K99 phase, I trained in integrative genomics and bioinformatics, early-life epidemiology, and placental biology and pathology with the help of my mentors and advisors Drs. Ke Hao, Jia Chen, Carmen Marsit and Dr. Harvey Kliman. The aims of this research are: 1) to construct an integrative epi/genomic catalogue of term placentas; 2) to characterize cell-type specific DNA methylome and transcriptome to construct a cell-type reference panel for human term placenta and 3) to evaluate the influence of placental molecular features on birth weight. In this proposal, I leverage existent epi/genomic and epidemiological data from the Rhode Island Birth Cohort Study and placental cell-type specific epi/genomics profiles with the overarching goal of mapping placental molecular features involved in birth weight and DOHaD. The knowledge gained through this research has the potential to inform more broadly on the influence of the intrauterine environment on health throughout the lifespan and develop placental biomarkers to inform disease prevention.

本建议的目标是整合多尺度epi/基因组胎盘分子特征并将其联系起来