TOPIC 421: BIOMIMETIC OPTICAL PHANTOMS FOR ADVANCING DEVELOPMENT OF FLUORESCENCE GUIDED SURGERY

主题 421：促进荧光引导手术发展的仿生光学体模

• 批准号: 10614903
• 负责人: ETHAN LAROCHELLE
• 金额: $ 5.5万
• 依托单位: QUEL IMAGING LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-16 至 2022-08-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10614903
• 关键词: Advanced Development; Biomimetics; Blood Vessels; Blood flow; Calibration; Cancerous; Complex; Computer Models; Contrast Media; Custom; Excision; Fluorescence; Image; Intravenous; Knowledge; Manufacturer Name; Molecular; Nature; Operative Surgical Procedures; Optics; Organ; Performance; Production; Property; Resolution; Shapes; Signal Transduction; Site; Specificity; System; Time; Tissue Model; Tissues; Validation; arteriole; base; blood perfusion; cloud based; cohesion; cost; experience; fluorescence-guided surgery; improved; rapid technique; tool

Fluorescence guidance for surgical resection of cancerous tissue is a rapidly growing field, providing real time guidance with molecular or vascular flow specificity. System calibration and performance validation is generally performed on an ad hoc basis and largely driven by manufacturers choices to minimize up-front cost, yet is entirely necessary as more manufacturers are approved. QUEL Imaging has developed methods for rapid production of tissue-simulating phantoms with controlled optical properties and fluorescence inclusions. Leveraging previous production experience, these surgical phantoms will be further developed to directly mimic both shape and function of organ sites commonly treated with surgical resection. Additionally, as fluorescence contrast is often administered intravenously and is dynamic in nature, phantoms with flow channels will be developed to better estimate the sensitivity and depth resolution of contrast agents in arterioles and small vessels. Finally, a computational match to each phantom will be developed to provide validated properties and the ability of users to verify signals based upon theoretical knowledge of their custom optical properties within the complex multi-layer tissue models. These customizable tools will bring cohesion and improved quality metrics to system developers by providing a simplified mechanism for companies and users to investigate capabilities and compare performance.

用于癌组织的手术切除的荧光引导是一个快速发展的领域，提供具有分子或血管流动特异性的真实的时间引导。系统校准和性能验证通常是在特定的基础上进行的，主要是由制造商的选择驱动，以最大限度地减少前期成本，但随着越来越多的制造商获得批准，这是完全必要的。QUEL Imaging开发了快速生产具有受控光学特性和荧光内含物的组织模拟体模的方法。利用以前的生产经验，这些手术模型将进一步发展，以直接模拟通常通过手术切除治疗的器官部位的形状和功能。此外，由于荧光造影剂通常是静脉内施用的，并且本质上是动态的，因此将开发具有流动通道的造影剂，以更好地估计造影剂在小动脉和小血管中的灵敏度和深度分辨率。最后，将开发与每个体模的计算匹配，以提供经验证的属性，并使用户能够根据复杂多层组织模型中自定义光学属性的理论知识来验证信号。这些可定制的工具将通过为公司和用户提供一种简化的机制来调查功能和比较性能，从而为系统开发人员带来凝聚力和改进的质量指标。