Regulation and Physiological Roles of Translational Fidelity
翻译保真度的调节和生理作用
基本信息
- 批准号:10617051
- 负责人:
- 金额:$ 6.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AffectAfrican American populationAntibioticsBacteriaBacteria sigma factor KatF proteinBiochemicalBiochemistryBiomedical ResearchCandidate Disease GeneCell Culture TechniquesCellsCellular biologyCommunicable DiseasesCritical PathwaysDevelopmentEnsureEvolutionExperimental DesignsFive-Year PlansFluorescenceFutureGenesGeneticGoalsHospitalizationImpairmentInfectionInternationalKnock-outKnowledgeLibrariesMass Spectrum AnalysisMicrobiologyMinority GroupsModelingMolecularMolecular BiologyMutationNutrientOsmolalitiesOutcomePathway interactionsPhysiologicalPopulationProtein BiosynthesisQuality ControlReadingRegulationReporterResearchResolutionRibosomesRoleSalmonellaSalmonella entericaScientistStressStudentsSystemSystems BiologyTemperatureTerminator CodonTestingThinkingTrainingTranslationsUnited StatesWestern BlottingWorkWritingbacterial geneticsbiological adaptation to stresscareer developmentcareer networkingcell motilitycost effectivedoctoral studentempoweredenvironmental stressorglobal healthhigh throughput screeninginterestlambda Spi-1macrophagemeetingsmicrobialnew technologynovelparent grantpathogenresponsesingle cell analysisskillsstudent mentoringtherapy developmenttransmission processunderrepresented minority student
项目摘要
PROJECT SUMMARY
The goal of this project is to enhance the diversity of the biomedical research workforce by
training a Ph.D. student from an underrepresented minority group
(African Americans) and facilitate her development towards an independent scientist in the field
of microbiology and pathogen-host interactions. The student will receive rigorous training to
study pathogen-host interactions, protein synthesis, bacterial genetics, and microbial stress
responses. Translational fidelity is critically maintained throughout evolution to ensure accurate
protein synthesis. However, the role of translational fidelity in pathogen-host interactions
remains largely unknown. The proposed training aims at studying how translational fidelity
affects Salmonella-macrophage interactions. During the training, the student will (a) develop
important research skills covering bacterial genetics, single-cell analyses, cell culture, molecular
biology, and biochemistry, (b) enhance her skills of critical reading, thinking, presentation, and
writing, and (c) strengthen her ability of proper experimental design and development of
hypothesis-driven research. In addition, the student will have the opportunities to further career
development by engaging in presenting research at local/national/international meetings,
mentoring students, and taking professional training courses. The outcomes of the proposed
training will help elucidate the role of translational fidelity in pathogen-host interactions using
Salmonella as a model, further the student’s development as an independent microbiologist,
expand the student’s professional network, and promote diversity in the workforce of
microbiology and infectious diseases.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('JIQIANG LING', 18)}}的其他基金
Regulation and Physiological Roles of Translational Fidelity
翻译保真度的调节和生理作用
- 批准号:
10619629 - 财政年份:2020
- 资助金额:
$ 6.48万 - 项目类别:
Regulation and Physiological Roles of Translational Fidelity
翻译保真度的调节和生理作用
- 批准号:
10725047 - 财政年份:2020
- 资助金额:
$ 6.48万 - 项目类别:
Regulation and Physiological Roles of Translational Fidelity
翻译保真度的调节和生理作用
- 批准号:
10406906 - 财政年份:2020
- 资助金额:
$ 6.48万 - 项目类别:
Regulation and Physiological Roles of Translational Fidelity
翻译保真度的调节和生理作用
- 批准号:
10166886 - 财政年份:2020
- 资助金额:
$ 6.48万 - 项目类别:
Studies of Aminoacyl-tRNA Synthetase Mutations Causing Progressive Microcephaly
氨酰基-tRNA 合成酶突变导致进行性小头畸形的研究
- 批准号:
9751423 - 财政年份:2018
- 资助金额:
$ 6.48万 - 项目类别:
Physiological impact of reduced fidelity in protein synthesis
蛋白质合成保真度降低的生理影响
- 批准号:
8932246 - 财政年份:2015
- 资助金额:
$ 6.48万 - 项目类别:
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