A Mobile Relational Agent to Enhance Atrial Fibrillation Self-care

增强心房颤动自我护理的移动关系代理

• 批准号: 10610784
• 负责人: Jared W. Magnani
• 金额: $ 21.16万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-27 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10610784
• 关键词: Address; Adherence; Advisory Committees; Anticoagulants; Anticoagulation; Atrial Fibrillation; Benchmarking; Black race; Cardiovascular Diseases; Cardiovascular system; Caring; Cellular Phone; Chronic; Chronic Disease; Clinic; Complement; Complex; Computer Literacy; Computers; Cues; Data; Disease Outcome; Education; Educational Curriculum; Electronic Health Record; Emergency Situation; Facial Expression; Gestures; Guidelines; Hand; Health; Health Educators; Health Promotion; Health Status; Health behavior outcomes; Health education; Health system; Heart Rate; Heart failure; Hospitalization; Incidence; Income; Individual; Information Systems; International; Intervention; Interview; Low income; Measurement; Measures; Medical Care Costs; Medical center; Modification; Monitor; Morbidity - disease rate; Myocardial Infarction; Outcome; Outcome Measure; Participant; Patient Care; Patient Outcomes Assessments; Patient Self-Report; Patient-Centered Care; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Pharmacy facility; Phase; Prevalence; Preventive treatment; Problem Solving; Public Health; Quality of life; Randomized; Randomized Clinical Trials; Research; Resources; Self Care; Self Efficacy; Speech; Stroke; Stroke prevention; Symptoms; System; Terminology; Testing; Universities; Visit; Voice; arm; base; clinical infrastructure; cohort; complex chronic conditions; cost; diaries; disabling symptom; efficacy evaluation; efficacy testing; ethnic minority; experience; gaze; health application; health care service utilization; health literacy; health related quality of life; heart rhythm; high risk; improved; innovation; intervention effect; intervention participants; mHealth; medical specialties; member; mortality; novel; novel strategies; optimal treatments; patient oriented; primary outcome; programs; racial and ethnic; recruit; secondary outcome; skills; social; social determinants; social factors; social health determinants; socioeconomics; standard care; stroke risk; success; symptom treatment

PROJECT SUMMARY Atrial fibrillation (AF) is a common, morbid condition. Symptoms, complex management, and significant adversity contribute to poor health-related quality of life (HRQoL). Social determinants of health exacerbate morbidity in AF, and limited health literacy compounds the poor patient experience of AF. We propose a single- center parallel group randomized clinical trial to test the efficacy of an embodied conversational agent (ECA) to improve patient-centered care in AF. The ECA is a computer character that simulates face-to-face conversation using voice, hand gesture, and gaze cues to provide education, monitoring and problem-solving. We have used the ECA in multiple health contexts for self-care and demonstrated its success to improve health behaviors and outcomes in individuals with limited computer and health literacy. Here we propose to expand our successful 30-day pilot (n=31) of the ECA and the AliveCor Kardia smartphone heart rate and rhythm monitor in order to evaluate the effect of a 4-month self-care curriculum and assess its 12-month sustainability. We will further test the integration of ECA/Kardia results in the electronic health record (EHR) and monitor alerts and resulting modifications to care. We will randomize 240 patients with AF who are receiving anticoagulation to either (1) the ECA/Kardia intervention, provided by smartphone, and accompanying EHR alerts, or (2) the control, consisting of an AF educational session, diary for recording symptoms and adherence, and a smartphone with a general health application for self-care (WebMD). Our trial will leverage the clinical infrastructure of the University of Pittsburgh Medical Center (UPMC) by recruiting at 8 UPMC clinics that share a common electronic health record. We will focus recruitment on individuals with limited socioeconomic resources, low health literacy, or racial/ethnic minorities. Our aims are: (1) To examine the effect of the ECA/Kardia intervention on patient-centered outcomes. We will evaluate HRQoL with the AF- specific AF Effect on QualiTy of life (AFEQT) measure and general HRQoL with the Patient-Reported Outcomes Measurement Information System-29 Profile at baseline, 4, and 12 months. (2) To evaluate the effect of the ECA/Kardia and EHR alert intervention on anticoagulant adherence. We will quantify adherence using medication possession ratio and pharmacy contact at 12 months, and complementary measures of self- reported non-adherence at baseline, 4, and 12 months. (3) To determine the effect of the intervention on health care utilization at 4 and 12 months using participant interview and the common EHR. Our trial will engage an 8- member patient advisory committee comprised of individuals with chronic AF to guide the intervention's cultural acceptability, recruitment, and presentation of results. Expected Results: In this project we will evaluate a scalable patient-centered intervention to improve HRQoL, improve anticoagulation adherence, and reduce health care utilization in vulnerable individuals with chronic AF. If proven successful, this intervention can be broadly disseminated to improve the care of patients with AF.

项目总结 房颤(房颤)是一种常见的病态疾病。症状、复杂的管理和重要的 逆境会导致与健康相关的生活质量(HRQOL)下降。健康的社会决定因素加剧 房颤的发病率和有限的健康素养加剧了房颤患者糟糕的经历。我们提议一个单一的- 中心平行组随机临床试验，以测试一种具体化对话制剂(ECA)对 改善房颤以病人为中心的护理。ECA是一个模拟面对面的计算机角色 使用语音、手势和凝视提示进行对话，以提供教育、监控和解决问题。 我们已经在多种健康情况下使用ECA进行自我护理，并证明了其成功地改善了 计算机和健康素养有限的个人的健康行为和结果。在此，我们建议 扩展我们的ECA和AliveCor Kardia智能手机成功的30天试点(n=31)心率和 节律监测，以评估4个月自我护理课程的效果，并评估其12个月的效果 可持续发展。我们将进一步测试ECA/Kardia结果在电子健康记录(EHR)中的整合情况 并监控警报和由此产生的修改以进行护理。我们将随机选择240名房颤患者 接受抗凝治疗(1)由智能手机提供的ECA/Kardia干预，以及 伴随的EHR警报，或(2)对照组，由房颤教育课程、用于记录的日记组成 症状和依从性，以及带有一般自我保健健康应用程序(WebMD)的智能手机。我们的审判 将利用匹兹堡大学医学中心(UPMC)的临床基础设施，在8 UPMC诊所共享共同的电子健康记录。我们将重点招聘具有以下条件的个人 社会经济资源有限，健康素养低，或少数族裔。我们的目标是：(1)审查 ECA/Kardia干预对以患者为中心的结果的影响。我们将与AF一起评估HRQOL- 房颤对患者生活质量(AFEQT)测量和总体HRQL的影响--报道 结果衡量信息系统-29基线、4个月和12个月的概况。(2)评估 Eca/Kardia和EHR警报干预对抗凝剂粘附性的影响我们将量化遵守情况 12个月时使用药物拥有率和药房接触情况，并辅以自我管理措施 报告在基线、4个月和12个月时未遵守。(3)确定干预对健康的影响 在4个月和12个月时，使用参与者访谈和普通电子病历进行护理利用。我们的审判将使用8- 由慢性房颤患者组成的成员患者咨询委员会指导干预的文化 可接受性、招聘和结果的展示。预期结果：在这个项目中，我们将评估一个 可扩展的以患者为中心的干预，以改善HRQL，提高抗凝依从性，并降低 慢性房颤易感个体的卫生保健利用情况。如果被证明成功，这种干预可能会 广泛传播以改善房颤患者的护理。