A Mobile Relational Agent to Enhance Atrial Fibrillation Self-care

增强心房颤动自我护理的移动关系代理

基本信息

项目摘要

PROJECT SUMMARY Atrial fibrillation (AF) is a common, morbid condition. Symptoms, complex management, and significant adversity contribute to poor health-related quality of life (HRQoL). Social determinants of health exacerbate morbidity in AF, and limited health literacy compounds the poor patient experience of AF. We propose a single- center parallel group randomized clinical trial to test the efficacy of an embodied conversational agent (ECA) to improve patient-centered care in AF. The ECA is a computer character that simulates face-to-face conversation using voice, hand gesture, and gaze cues to provide education, monitoring and problem-solving. We have used the ECA in multiple health contexts for self-care and demonstrated its success to improve health behaviors and outcomes in individuals with limited computer and health literacy. Here we propose to expand our successful 30-day pilot (n=31) of the ECA and the AliveCor Kardia smartphone heart rate and rhythm monitor in order to evaluate the effect of a 4-month self-care curriculum and assess its 12-month sustainability. We will further test the integration of ECA/Kardia results in the electronic health record (EHR) and monitor alerts and resulting modifications to care. We will randomize 240 patients with AF who are receiving anticoagulation to either (1) the ECA/Kardia intervention, provided by smartphone, and accompanying EHR alerts, or (2) the control, consisting of an AF educational session, diary for recording symptoms and adherence, and a smartphone with a general health application for self-care (WebMD). Our trial will leverage the clinical infrastructure of the University of Pittsburgh Medical Center (UPMC) by recruiting at 8 UPMC clinics that share a common electronic health record. We will focus recruitment on individuals with limited socioeconomic resources, low health literacy, or racial/ethnic minorities. Our aims are: (1) To examine the effect of the ECA/Kardia intervention on patient-centered outcomes. We will evaluate HRQoL with the AF- specific AF Effect on QualiTy of life (AFEQT) measure and general HRQoL with the Patient-Reported Outcomes Measurement Information System-29 Profile at baseline, 4, and 12 months. (2) To evaluate the effect of the ECA/Kardia and EHR alert intervention on anticoagulant adherence. We will quantify adherence using medication possession ratio and pharmacy contact at 12 months, and complementary measures of self- reported non-adherence at baseline, 4, and 12 months. (3) To determine the effect of the intervention on health care utilization at 4 and 12 months using participant interview and the common EHR. Our trial will engage an 8- member patient advisory committee comprised of individuals with chronic AF to guide the intervention's cultural acceptability, recruitment, and presentation of results. Expected Results: In this project we will evaluate a scalable patient-centered intervention to improve HRQoL, improve anticoagulation adherence, and reduce health care utilization in vulnerable individuals with chronic AF. If proven successful, this intervention can be broadly disseminated to improve the care of patients with AF.
项目总结 房颤(房颤)是一种常见的病态疾病。症状、复杂的管理和重要的 逆境会导致与健康相关的生活质量(HRQOL)下降。健康的社会决定因素加剧 房颤的发病率和有限的健康素养加剧了房颤患者糟糕的经历。我们提议一个单一的- 中心平行组随机临床试验,以测试一种具体化对话制剂(ECA)对 改善房颤以病人为中心的护理。ECA是一个模拟面对面的计算机角色 使用语音、手势和凝视提示进行对话,以提供教育、监控和解决问题。 我们已经在多种健康情况下使用ECA进行自我护理,并证明了其成功地改善了 计算机和健康素养有限的个人的健康行为和结果。在此,我们建议 扩展我们的ECA和AliveCor Kardia智能手机成功的30天试点(n=31)心率和 节律监测,以评估4个月自我护理课程的效果,并评估其12个月的效果 可持续发展。我们将进一步测试ECA/Kardia结果在电子健康记录(EHR)中的整合情况 并监控警报和由此产生的修改以进行护理。我们将随机选择240名房颤患者 接受抗凝治疗(1)由智能手机提供的ECA/Kardia干预,以及 伴随的EHR警报,或(2)对照组,由房颤教育课程、用于记录的日记组成 症状和依从性,以及带有一般自我保健健康应用程序(WebMD)的智能手机。我们的审判 将利用匹兹堡大学医学中心(UPMC)的临床基础设施,在8 UPMC诊所共享共同的电子健康记录。我们将重点招聘具有以下条件的个人 社会经济资源有限,健康素养低,或少数族裔。我们的目标是:(1)审查 ECA/Kardia干预对以患者为中心的结果的影响。我们将与AF一起评估HRQOL- 房颤对患者生活质量(AFEQT)测量和总体HRQL的影响--报道 结果衡量信息系统-29基线、4个月和12个月的概况。(2)评估 Eca/Kardia和EHR警报干预对抗凝剂粘附性的影响我们将量化遵守情况 12个月时使用药物拥有率和药房接触情况,并辅以自我管理措施 报告在基线、4个月和12个月时未遵守。(3)确定干预对健康的影响 在4个月和12个月时,使用参与者访谈和普通电子病历进行护理利用。我们的审判将使用8- 由慢性房颤患者组成的成员患者咨询委员会指导干预的文化 可接受性、招聘和结果的展示。预期结果:在这个项目中,我们将评估一个 可扩展的以患者为中心的干预,以改善HRQL,提高抗凝依从性,并降低 慢性房颤易感个体的卫生保健利用情况。如果被证明成功,这种干预可能会 广泛传播以改善房颤患者的护理。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Jared W. Magnani其他文献

Integrating Digital Coaching into Cardiac Practice: Strategies to Advance Health Equity
  • DOI:
    10.1007/s12170-024-00743-8
  • 发表时间:
    2024-08-09
  • 期刊:
  • 影响因子:
    1.800
  • 作者:
    Erin M. Schikowski;Arinze Bosah;Anisha Reddy;Sam Younes;Jared W. Magnani
  • 通讯作者:
    Jared W. Magnani
The mobile health intervention for rural patients with atrial fibrillation a randomized controlled trial
针对农村房颤患者的移动健康干预:一项随机对照试验
  • DOI:
    10.1016/j.ijcard.2025.133575
  • 发表时间:
    2025-11-01
  • 期刊:
  • 影响因子:
    3.200
  • 作者:
    Jared W. Magnani;Keri Plevniak;Danielle Ferry;Deborah Martin;Maria M. Brooks;Everlyne Kimani;Stefán Ólafsson;Bruce L. Rollman;Michael K. Paasche-Orlow;Samar R. El Khoudary;Timothy Bickmore
  • 通讯作者:
    Timothy Bickmore
EPIDEMIOLOGY OF P WAVE INDICES IN HEALTHY POST-MENOPAUSAL WOMEN: THE WOMEN’S HEALTH INITIATIVE
  • DOI:
    10.1016/s0735-1097(10)60126-x
  • 发表时间:
    2010-03-09
  • 期刊:
  • 影响因子:
  • 作者:
    Eiran Z. Gorodeski;Jared W. Magnani;Ronald J. Prineas;Mara Z. Vitolins;Mary J. O’Sullivan;Elsayed Z. Soliman;Lisa W. Martin;Marian C. Limacher;J. David Curb;Barbara B. Cochrane;Eugene H. Blackstone;Michael S. Lauer
  • 通讯作者:
    Michael S. Lauer
A mobile relational agent to enhance atrial fibrillation self-care: Primary and secondary outcomes of a randomized controlled trial
一种用于增强房颤自我护理的移动关系代理:一项随机对照试验的主要和次要结果
  • DOI:
    10.1016/j.ahj.2025.06.009
  • 发表时间:
    2025-12-01
  • 期刊:
  • 影响因子:
    3.500
  • 作者:
    Jared W. Magnani;Christina M. Lalama;Kaleab Z. Abebe;Danielle Ferry;Bruce L. Rollman;Michelle Q. Lancet;Everlyne Kimani;Stefán Ólafsson;Timothy Bickmore;Michael K. Paasche-Orlow
  • 通讯作者:
    Michael K. Paasche-Orlow
The barbershop paradigm: Community engagement for cardiovascular prevention
理发店范式:社区参与预防心血管疾病

Jared W. Magnani的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Jared W. Magnani', 18)}}的其他基金

Mentoring in patient-oriented research in social determinants and atrial fibrillation
指导以患者为中心的社会决定因素和心房颤动研究
  • 批准号:
    10687127
  • 财政年份:
    2022
  • 资助金额:
    $ 21.16万
  • 项目类别:
Mentoring in patient-oriented research in social determinants and atrial fibrillation
指导以患者为中心的社会决定因素和心房颤动研究
  • 批准号:
    10523302
  • 财政年份:
    2022
  • 资助金额:
    $ 21.16万
  • 项目类别:
A Mobile Relational Agent to Enhance Atrial Fibrillation Self-care
增强心房颤动自我护理的移动关系代理
  • 批准号:
    10377942
  • 财政年份:
    2020
  • 资助金额:
    $ 21.16万
  • 项目类别:
A Mobile Relational Agent to Enhance Atrial Fibrillation Self-care
增强心房颤动自我护理的移动关系代理
  • 批准号:
    10611982
  • 财政年份:
    2020
  • 资助金额:
    $ 21.16万
  • 项目类别:
A Mobile Relational Agent to Enhance Atrial Fibrillation Self-care
增强心房颤动自我护理的移动关系代理
  • 批准号:
    10153869
  • 财政年份:
    2020
  • 资助金额:
    $ 21.16万
  • 项目类别:
Diversity Supplement for geocoding in the parent grant "A Mobile Relational Agent to Enhance Atrial Fibrillation self-care"
家长补助金中地理编码的多样性补充“增强心房颤动自我护理的移动关系代理”
  • 批准号:
    10164339
  • 财政年份:
    2020
  • 资助金额:
    $ 21.16万
  • 项目类别:
A Mobile Relational Agent to Enhance Atrial Fibrillation Self-care
增强心房颤动自我护理的移动关系代理
  • 批准号:
    10831234
  • 财政年份:
    2020
  • 资助金额:
    $ 21.16万
  • 项目类别:
ConProject-001
ConProject-001
  • 批准号:
    10153870
  • 财政年份:
    2020
  • 资助金额:
    $ 21.16万
  • 项目类别:
ConProject-002
ConProject-002
  • 批准号:
    10153872
  • 财政年份:
    2020
  • 资助金额:
    $ 21.16万
  • 项目类别:
Mobile Health intervention for rural atrial fibrillation
农村房颤的移动健康干预
  • 批准号:
    10240320
  • 财政年份:
    2019
  • 资助金额:
    $ 21.16万
  • 项目类别:

相似海外基金

I-Corps: Medication Adherence System
I-Corps:药物依从性系统
  • 批准号:
    2325465
  • 财政年份:
    2023
  • 资助金额:
    $ 21.16万
  • 项目类别:
    Standard Grant
Improving Repositioning Adherence in Home Care: Supporting Pressure Injury Care and Prevention
提高家庭护理中的重新定位依从性:支持压力损伤护理和预防
  • 批准号:
    490105
  • 财政年份:
    2023
  • 资助金额:
    $ 21.16万
  • 项目类别:
    Operating Grants
An innovative, AI-driven prehabilitation platform that increases adherence, enhances post-treatment outcomes by at least 50%, and provides cost savings of 95%.
%20创新、%20AI驱动%20康复%20平台%20%20增加%20依从性、%20增强%20治疗后%20结果%20by%20at%20至少%2050%、%20和%20提供%20成本%20节省%20of%2095%
  • 批准号:
    10057526
  • 财政年份:
    2023
  • 资助金额:
    $ 21.16万
  • 项目类别:
    Grant for R&D
CO-LEADER: Intervention to Improve Patient-Provider Communication and Medication Adherence among Patients with Systemic Lupus Erythematosus
共同领导者:改善系统性红斑狼疮患者的医患沟通和药物依从性的干预措施
  • 批准号:
    10772887
  • 财政年份:
    2023
  • 资助金额:
    $ 21.16万
  • 项目类别:
Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples with Implications for Alzheimer’s Disease Risk
Nuestro Sueno:夫妻干预措施的文化适应,以改善拉丁裔夫妇的 PAP 依从性和睡眠健康,对阿尔茨海默病风险产生影响
  • 批准号:
    10766947
  • 财政年份:
    2023
  • 资助金额:
    $ 21.16万
  • 项目类别:
Pharmacy-led Transitions of Care Intervention to Address System-Level Barriers and Improve Medication Adherence in Socioeconomically Disadvantaged Populations
药房主导的护理干预转型,以解决系统层面的障碍并提高社会经济弱势群体的药物依从性
  • 批准号:
    10594350
  • 财政年份:
    2023
  • 资助金额:
    $ 21.16万
  • 项目类别:
Unintrusive Pediatric Logging Orthotic Adherence Device: UPLOAD
非侵入式儿科记录矫形器粘附装置:上传
  • 批准号:
    10821172
  • 财政年份:
    2023
  • 资助金额:
    $ 21.16万
  • 项目类别:
Antiretroviral therapy adherence and exploratory proteomics in virally suppressed people with HIV and stroke
病毒抑制的艾滋病毒和中风患者的抗逆转录病毒治疗依从性和探索性蛋白质组学
  • 批准号:
    10748465
  • 财政年份:
    2023
  • 资助金额:
    $ 21.16万
  • 项目类别:
Improving medication adherence and disease control for patients with multimorbidity: the role of price transparency tools
提高多病患者的药物依从性和疾病控制:价格透明度工具的作用
  • 批准号:
    10591441
  • 财政年份:
    2023
  • 资助金额:
    $ 21.16万
  • 项目类别:
Development and implementation of peer-facilitated decision-making and referral support to increase uptake and adherence to HIV pre-exposure prophylaxis in African Caribbean and Black communities in Ontario
制定和实施同行协助决策和转介支持,以提高非洲加勒比地区和安大略省黑人社区对艾滋病毒暴露前预防的接受和依从性
  • 批准号:
    491109
  • 财政年份:
    2023
  • 资助金额:
    $ 21.16万
  • 项目类别:
    Fellowship Programs
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了