IGF::OT::IGF Development and Maintenance of the Caloric Restricted Rodent Breeding and Aging Colonies

IGF::OT::IGF 热量限制啮齿动物繁殖和老化群体的开发和维护

• 批准号: 10618125
• 负责人: TERRENCE FISHER
• 金额: $ 4.79万
• 依托单位: CHARLES RIVER LABORATORIES INTNTL, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-10 至 2016-09-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10618125
• 关键词: Adult; Aging; Animals; Biology; Body Weight; Breeding; Caloric Restriction; Development; Disease; Environment; Genetic; Genetic Markers; Health; Health Status; Intervention; Laboratories; Longevity; Maintenance; Monitor; Nutritional; Physiological; Research; Research Personnel; Rodent; aged; improved; normal aging; programs

Caloric restriction, in which the calories are restricted to maintain a stable adult body weight but all other nutritional needs are met, is the only proven intervention to extend life span and improve health. Calorically restricted rodents are used to investigate the cellular and physiological biology of normal aging. A colony of aged, calorically restricted laboratory rodents, of defined genetic backgrounds and health status, is an integral part of the NIA's program of research on aging. The purpose of this project is to develop, maintain and distribute a standing colony ofaged, calorically restricted rodents ofdefined strains for use by investigators in studies of aging.

热量限制，即限制热量以维持稳定的成年体重，但满足所有其他营养需求，是唯一被证明可以延长寿命和改善健康的干预措施。限制热量的啮齿动物被用来研究正常衰老的细胞和生理生物学。一群老年的、热量受限的实验室啮齿动物，具有明确的遗传背景和健康状况，是NIA衰老研究计划的一个组成部分。本项目的目的是开发、维持和分发一个固定的种群，这些种群是由确定品系的老年、热量限制的啮齿动物组成，供研究人员在衰老研究中使用。