IGF::OT::IGF Development and Maintenance of the Caloric Restricted Rodent Breeding and Aging Colonies

卡路里限制，即限制卡路里以维持成年人稳定的体重，但满足所有其他营养需求，是唯一被证明可以延长寿命和改善健康的干预措施。卡路里限制的啮齿动物被用来研究正常衰老的细胞和生理生物学。一群年迈的、卡路里受限的实验室啮齿动物，具有明确的遗传背景和健康状况，是NIA老龄化研究计划的组成部分。这个项目的目的是开发、维护和分布一个固定的老化、卡路里限制的啮齿类动物群体，供研究人员在衰老研究中使用。

Caloric restriction, in which the calories are restricted to maintain a stable adult body weight but all other nutritional needs are met, is the only proven intervention to extend life span and improve health. Calorically restricted rodents are used to investigate the cellular and physiological biology of normal aging. A colony of aged, calorically restricted laboratory rodents, of defined genetic backgrounds and health status, is an integral part of the NIA's program of research on aging. The purpose of this project is to develop, maintain and distribute a standing colony ofaged, calorically restricted rodents ofdefined strains for use by investigators in studies of aging.