Pilot and Feasibility Program

总结 试点/可行性（P/F）计划是哥伦比亚大学消化系统的核心组成部分， 肝病研究中心（CU-DLDRC）。其主要目标将是促进高度创新的 研究和扩大消化系统疾病相关的研究机会，以新的研究人员。P/F 该计划建立在哥伦比亚成功的试点资金和初级PI职业建设的悠久历史之上 大学医学中心（CUIMC）。我们在2019年成功建立了这个项目，并资助了七个 到目前为止，研究人员在获得NIH或同等资金方面的成功率很高， 25倍的回报率。P/F由两名在成人和儿科消化道领域具有杰出专业知识的主任领导 疾病研究和管理，Kara Margolis博士和Utpal Pajvani博士P/F计划将提供 每年三笔2.5万美元的赠款，两笔来自CU-DLDRCC基金，另一笔来自机构支持， 使合格的研究者能够探索与CU-DLDRCC的两个中心主题之一相关的假设， 为了收集足够的数据，以制定研究计划和资助申请同行评审 校外资助P/F奖按优先顺序资助不同的轨道。途径1：新的调查人员寻求 初步支持。轨道2：新的或已建立的研究人员，旨在追求创新的高风险，高回报 消化系统疾病的项目。途径3：来自其他领域的知名调查人员， 消化系统疾病的研究。P/F计划将与其他预防性措施高度协同 以及CUIMC的以临床为重点的内部资助机制。P/F获奖者将享受额外的 这些好处将大大促进他们的研究，包括生物医学核心补贴，远远超出 资助期限;通过丰富的整合到我们的综合学术导师计划 项目整合以及CU-DLDRC在研究和教育方面的活动，如临床基础团队， 讲习班和研讨会。P/F计划将通过三个方面为CU-DLRDC的使命做出贡献 具体目标：征集和严格的同行评审申请，从而支持高度创新的研究 以及消化研究的后起之秀（目标1）;通过以下方式最大限度地提高P/F资助研究人员的成功率 科学互动、教育、培训和指导的机会以及CU-DLDRC核心补贴 (Aim 2）;并通过长期跟踪获奖者，有效监督P/F计划的成果 出版物和赠款（目标3）。我们预计P/F计划将促进高度多样化的发展， 基础和临床人才，并促进创新的影响力科学超越目前的消化 research.这三个目标将在增加多样性，公平和包容性（DEI）的目标下，通过 与丰富计划，其DEI代表和广泛的DEI资源在哥伦比亚的合作。 我们已经取得了初步的成功，利用CU-DLDRC和机构合作和资源。

SUMMARY The Pilot/Feasibility (P/F) Program represents a central component of the Columbia University Digestive and Liver Disease Research Center (CU-DLDRC). Its primary objectives will be the promotion of highly innovative research and the expansion of digestive disease-related research opportunities to new investigators. The P/F Program is built on a long history of successful pilot funding and career building of junior PIs within Columbia University Medical Center (CUIMC). We successfully established this program in 2019 and have funded seven investigators thus far, who have enjoyed a high rate of success in obtaining NIH or equivalent funding, providing a >25-fold rate of return. The P/F is led by two directors with outstanding expertise in adult and pediatric digestive disease research and administration, Drs. Kara Margolis and Dr. Utpal Pajvani. The P/F Program will provide three grants of $25k each year, two from CU-DLDRCC funds and another from institutional support, that will enable eligible investigators to explore hypotheses related to one of the two central themes of the CU-DLDRCC, in order to gather sufficient data to develop research programs and grant applications for peer-reviewed extramural funding. The P/F awards fund different tracks, in prioritized order. Track 1: New investigators seeking initial support. Track 2: New or established investigators aiming to pursue innovative high-risk, high-reward projects in digestive disease. Track 3: Established investigators from other fields who seek to apply their expertise to research in digestive disease. The P/F Program will be highly synergistic with other translationally and clinically focused intramural internal funding mechanisms at CUIMC. P/F awardees will enjoy additional benefits that will substantially promote their research, including Biomedical Core subsidies that go far beyond the funding duration; integration into our comprehensive academic mentorship program via the Enrichment Program integration as well as into CU-DLDRC activities in research and education such as clinical-basic teams, workshops and seminars. The P/F program will contribute to the mission of the CU-DLRDC through three Specific Aims: To solicit and rigorously peer review applications, thereby supporting highly innovative research as well as rising stars in digestive research (Aim 1); to maximize the success of P/F-funded researchers through opportunities for scientific interactions, education, training and mentorship as well as CU-DLDRC core subsidies (Aim 2); and to provide efficient oversight of P/F program outcomes through long-term tracking of awardees publications and grants (Aim 3). We anticipate the P/F program to enhance the development of the highly diverse basic and clinical talent and to promote innovative impactful science beyond the horizon of current digestive research. These three Aims will be under the goal of increasing Diversity, Equity and Inclusion (DEI), through collaboration with the Enrichment Program, its DEI delegate and the wide range of DEI resources at Columbia. We have achieved initial success already, leveraging CU-DLDRC and institutional collaborations and resources.