Clinical Core

约翰霍普金斯大学CFAR临床核心（CC）旨在促进生成， 成熟，并实施新的以患者为导向的临床和转化研究， 重点关注NIH支持的艾滋病科学研究的关键领域。我们的模型是基于 我们的前提是，当研究人员可以讨论临床挑战时， 当这些问题在高度支持的知识分子中孵化时，就会成为成功的研究 环境，可以提供充足的临床研究资源。总体目标 的CC是通过提供环境，资源， 开展HIV相关临床和转化研究所需的关键支持。 解决艾滋病毒相关的合并症和合并感染仍然是一个高度优先领域， CC已经在约翰霍普金斯的一些科学和临床资源之间建立了桥梁。混合 艾滋病毒，老龄化和物质使用影响我们的病人突出了日益增长的重要性， 艾滋病毒的神经认知并发症，这一领域将具有更独特的作用， 将我们的中枢神经系统功能障碍科学工作组的工作纳入CC。的CC 还建立了支持临床研究的能力和专业知识， 终止艾滋病毒流行的目标，包括研究通过以下途径预防艾滋病毒传播 提供治疗，促进艾滋病毒治愈，减少艾滋病毒护理提供方面的差距， 结果。在这一框架内，我们的具体目标是：1）支持新的和已建立的 研究人员在进行艾滋病毒患者为基础的临床研究。这将通过提供 协调使用设施和已建立的数据库， 由经验丰富的协调员进行研究，并利用专业知识的广度和深度， 约翰霍普金斯的器官系统研究，2）促进跨学科的艾滋病毒临床研究 通过协调新的和建立的研究方法和思想之间的交流 investigators.具体做法是促进思想交流， 通过每周一次的艾滋病毒临床研究系列研讨会和其他活动， 场地，以及3）为初级和中级教师提供指导，以培养下一代 HIV临床研究者通过从方案制定、IRB 审批、数据收集、分析和稿件准备，并由初级 通过我们的系列研讨会和直接培训，将调查员介绍给资深调查员。 所有这些都是与其他CFAR核心和SWG合作完成的， 在我们机构的整个CFAR和科学界的投入和合作。

The Johns Hopkins University CFAR Clinical Core (CC) is designed to promote the generation, maturation, and implementation of new patient-oriented, clinical and translational investigation, with a focus on key areas for NIH-supported HIV scientific research. Our model is grounded in our premise that new research arises when investigators can discuss clinical challenges and these questions become successful research when incubated in a highly supportive intellectual environment and where ample clinical research resources can be provided. The overarching goal of the CC is to foster new HIV clinical research by providing the environment, the resources, and the critical support necessary for the conduct of HIV-associated clinical and translational studies. Addressing HIV-associated comorbidities and co-infections continues to be a high-priority area in which the CC has bridged a number of scientific and clinical resources at Johns Hopkins. The mix of HIV, aging, and substance use affecting our patients highlights the growing importance of neurocognitive complications in HIV, an area that will have a more distinctive role with an integration of the work of our CNS Dysfunction Scientific Working Group into the CC. The CC has also established the capacity and expertise to support clinical research in areas that support the goals of Ending the HIV Epidemic, including research to prevent HIV transmission through provision of treatment, to promote HIV cure, and to reduce disparities in HIV care delivery and outcomes. Within this framework, our Specific Aims are to: 1) Support new and established investigators in conducting HIV patient-based clinical research. This will be done by providing coordinated access to facilities and established databases, direct assistance in the conduct of research by experienced coordinators, and leveraging the breadth and depth of expertise in organ-system research at Johns Hopkins, 2) Promote interdisciplinary HIV clinical research through coordinated exchanges of research methods and ideas among new and established investigators. This will be done by specifically fostering the exchange of ideas and the development of new research through a weekly HIV clinical research seminar series and other venues, and, 3) Provide mentoring to junior and mid-level faculty to develop the next generation of HIV clinical investigators through each step of the process from protocol development, IRB approval, data collection, analysis and manuscript preparation, and by the linkage of junior investigators to established senior investigators through our seminar series and direct training. All of this is done in collaboration with the other CFAR Cores and SWGs to maximize intellectual input and collaboration across the entire CFAR and scientific community at our institution.