The Nathan Schnaper Intern Program in Translational Cancer Research

检测和治疗方面的重大进展降低了癌症死亡率;然而， 2019年报告的癌症新病例和60万例死亡，预计它仍然是一个主要的健康问题， 超过心血管疾病成为美国的主要死因到2020年增长的部分 65岁以上和癌症风险升高的人口增加了这种疾病的负担。这些数据 强调需要新的方法来治疗癌症和癌症幸存者的管理， 预计到2026年将超过2000万。我们对基本生物学机制的理解进展 在人类癌症中被破坏以促进肿瘤发生的基因以前所未有的速度发展， 为满足这一需求所需的新型治疗干预提供了一个温床。目前的挑战是 缩小实验室发现与临床应用之间日益扩大的差距。 事实上，创建一个精简的翻译管道是癌症登月计划的优先事项。尽管有这些 在影响患者结果的前所未有的机会中，缺乏年轻的科学家和临床医生 具有强大的癌症生物学背景，预计对肿瘤学家的需求将超过供应， 到2025年，这一领域的医生。因此，激励和培训下一代癌症研究人员， 肿瘤学家是加速将研究突破转化为新诊断的核心， 治疗学Nathan Schnaper Intern Program in Translational Research（NISP） 马里兰州Greenebaum综合癌症中心寻求通过三个具体目标实现这一目标： 1)招募有才华且多元化的本科实习生，对癌症研究和/或 临床肿瘤学的研究。2)整合指导研究、教育模块和 临床接触，为实习生提供转化癌症研究的实践经验，让他们兴奋不已 3）评估项目成果，并传播这一成果。 信息，以确定和分享最佳实践，跟踪实习生校友的进展作为计划的关键指标 并发展能力建设伙伴关系。NSIP在培训实习生方面有着悠久的历史， 对癌症生物学的开创性贡献目前的建议建立在这一历史和第一次成功的基础上 在供资期内，通过增加具有创新性的人口科学组成部分的强有力的夏季课程。新 癌症流行病学，差异和生存率模块为实习生提供了更广阔的视角， 癌症研究、护理和就业机会。此外，作为扩大癌症教育管道的一部分， NSIP现在由九个项目组成，NSIP实习生通过联合论坛从近同行网络中受益 这些信息会影响他们的教育和职业道路决定。将创新的新模块与 在下一个资助期内，已建立的NSIP组件将完成研究，教育，培训和劳动力 癌症研究教育赠款计划的发展目标是NCI使命的组成部分。

Significant progress in detection and treatment has reduced cancer mortality rates; however, with over 1.7 million new cases and 600,000 deaths from cancer reported in 2019, it remains a major health concern that is predicted to surpass cardiovascular disease as the major cause of death in the US. by 2020. The growing segment of the population that is over 65 years of age and at elevated risk for cancer adds to this disease burden. These data highlight the need for new approaches to cancer treatment and its management in cancer survivors who are projected to exceed 20 million by 2026. Advances in our understanding of fundamental biological mechanisms that are disrupted in human cancers to promote oncogenesis have progressed at an unparalleled rate and provide a seedbed for the novel therapeutic interventions required to fill this need. The current challenge is to close this widening gap between laboratory discoveries and their clinical applications in the fight against cancer. Indeed, creating a streamlined translational pipeline is a priority of the Cancer Moonshot Initiative. Despite these unprecedented opportunities to impact patient outcomes, there is a shortage of young scientists and clinicians with a strong background in cancer biology and the demand for oncologists is predicted to outpace the supply of clinicians in this field by 2025. Thus, inspiring and training the next generation of cancer researchers and oncologists is central to accelerating the translation of research breakthroughs into new diagnostics and therapeutics. The Nathan Schnaper Intern Program in Translational Research (NISP) at the University of Maryland Greenebaum Comprehensive Cancer Center seeks to achieve this goal through three specific aims: 1) Recruit talented and diverse cohorts of undergraduate interns with an interest in cancer research and/or clinical oncology from institutions across the US. 2) Integrate mentored research, educational modules and clinical exposure to provide interns with hands-on experience in translational cancer research, excite them about careers in this field and foster their success on this path. 3) Evaluate program outcomes and disseminate this information to identify and share best practices, track the progress of intern alumni as a key metric of program success and develop capacity-building partnerships. The NSIP has a strong history of training interns who make seminal contributions to cancer biology. The current proposal builds upon this history, and successes of the first funding period, by augmenting a robust summer curriculum with innovative population science components. New modules in cancer epidemiology, disparities, and survivorship provide interns with a broader perspective of cancer research, care and career opportunities. Furthermore, as part of an expanded cancer education pipeline that is now comprised of nine programs, NSIP interns benefit from near peer networking through joint forums that inform and impact their educational and career path decisions. Incorporation of innovative new modules with established NSIP components in the next funding period will fulfill the research, education, training and workforce development goals of the Cancer Research Education Grants Program that are integral to the NCI mission.