The Nathan Schnaper Intern Program in Translational Cancer Research

内森·施纳珀 (Nathan Schnaper) 转化癌症研究实习生计划

• 批准号: 10089616
• 负责人: BRET A HASSEL
• 金额: $ 32.42万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10089616
• 关键词: Age-Years; Biological; Cancer Biology; Cancer Detection; Cancer Survivor; Cardiovascular Diseases; Career Choice; Caring; Cause of Death; Cessation of life; Clinical; Clinical Oncology; Comprehensive Cancer Center; Data; Detection; Educational Curriculum; Exposure to; Fostering; Funding; Goals; Grant; Health; Human; Institution; Internships; Joints; Laboratories; Learning Module; Malignant Neoplasms; Maryland; Mentors; Mission; Oncologist; Outcome; Patient-Focused Outcomes; Population; Population Sciences; Recording of previous events; Reporting; Research; Research Personnel; Scientist; Seminal; Talents; Training; Training and Education; Translational Research; Universities; Workforce Development; anticancer research; burden of illness; cancer education; cancer epidemiology; cancer risk; cancer therapy; career; clinical application; cohort; education pathway; education research; experience; fight against; innovation; interest; mortality; next generation; novel diagnostics; novel strategies; novel therapeutic intervention; novel therapeutics; peer networks; programs; recruit; success; survivorship; translational cancer research; translational pipeline; tumorigenesis; undergraduate student

Significant progress in detection and treatment has reduced cancer mortality rates; however, with over 1.7 million new cases and 600,000 deaths from cancer reported in 2019, it remains a major health concern that is predicted to surpass cardiovascular disease as the major cause of death in the US. by 2020. The growing segment of the population that is over 65 years of age and at elevated risk for cancer adds to this disease burden. These data highlight the need for new approaches to cancer treatment and its management in cancer survivors who are projected to exceed 20 million by 2026. Advances in our understanding of fundamental biological mechanisms that are disrupted in human cancers to promote oncogenesis have progressed at an unparalleled rate and provide a seedbed for the novel therapeutic interventions required to fill this need. The current challenge is to close this widening gap between laboratory discoveries and their clinical applications in the fight against cancer. Indeed, creating a streamlined translational pipeline is a priority of the Cancer Moonshot Initiative. Despite these unprecedented opportunities to impact patient outcomes, there is a shortage of young scientists and clinicians with a strong background in cancer biology and the demand for oncologists is predicted to outpace the supply of clinicians in this field by 2025. Thus, inspiring and training the next generation of cancer researchers and oncologists is central to accelerating the translation of research breakthroughs into new diagnostics and therapeutics. The Nathan Schnaper Intern Program in Translational Research (NISP) at the University of Maryland Greenebaum Comprehensive Cancer Center seeks to achieve this goal through three specific aims: 1) Recruit talented and diverse cohorts of undergraduate interns with an interest in cancer research and/or clinical oncology from institutions across the US. 2) Integrate mentored research, educational modules and clinical exposure to provide interns with hands-on experience in translational cancer research, excite them about careers in this field and foster their success on this path. 3) Evaluate program outcomes and disseminate this information to identify and share best practices, track the progress of intern alumni as a key metric of program success and develop capacity-building partnerships. The NSIP has a strong history of training interns who make seminal contributions to cancer biology. The current proposal builds upon this history, and successes of the first funding period, by augmenting a robust summer curriculum with innovative population science components. New modules in cancer epidemiology, disparities, and survivorship provide interns with a broader perspective of cancer research, care and career opportunities. Furthermore, as part of an expanded cancer education pipeline that is now comprised of nine programs, NSIP interns benefit from near peer networking through joint forums that inform and impact their educational and career path decisions. Incorporation of innovative new modules with established NSIP components in the next funding period will fulfill the research, education, training and workforce development goals of the Cancer Research Education Grants Program that are integral to the NCI mission.

在检测和治疗方面取得的重大进展降低了癌症死亡率；然而，有170多万人 2019年报告的癌症新增病例和60万人死亡，预计仍是一个主要的健康问题 超过心血管疾病成为美国的主要死亡原因。到2020年。不断增长的细分市场 65岁以上和癌症风险较高的人群增加了这种疾病的负担。这些数据 强调需要新的癌症治疗方法及其对癌症幸存者的管理 预计到2026年将超过2000万。我们对基本生物学机制的认识进展 在人类癌症中被干扰以促进肿瘤形成的基因以前所未有的速度进展， 为满足这一需求所需的新型治疗干预措施提供苗床。目前的挑战是 缩小实验室发现与抗癌临床应用之间日益扩大的差距。 事实上，创建一条精简的翻译管道是癌症登月倡议的优先事项。尽管如此 影响患者预后的前所未有的机会，年轻科学家和临床医生短缺 拥有强大的癌症生物学背景，预计对肿瘤学家的需求将超过供应 到2025年这一领域的临床医生。因此，激励和培训下一代癌症研究人员和 肿瘤学家是加速将研究突破转化为新诊断和新技术的核心 治疗学。内森·施纳普翻译研究实习生项目(NISP) 马里兰州格林鲍姆综合癌症中心寻求通过三个具体目标实现这一目标： 1)招聘对癌症研究和/或有兴趣的本科生实习生，这些人才华横溢，形式多样 来自美国各地机构的临床肿瘤学。2)整合有指导的研究、教育模块和 临床暴露为实习生提供转化性癌症研究的实践经验，使他们对 在这一领域的职业，并促进他们在这条道路上的成功。3)评估计划成果并进行宣传 确定和分享最佳实践的信息，跟踪实习生校友的进展情况，作为计划的关键指标 取得成功，发展能力建设伙伴关系。NSIP有很强的实习生培训历史，这些实习生 对癌症生物学的开创性贡献。目前的提议建立在这一历史的基础上，第一次的成功 在资助期内，通过采用创新的人口科学内容来加强强有力的暑期课程。新的 癌症流行病学、差异和生存方面的模块为实习生提供了更广阔的视角 癌症研究、护理和职业机会。此外，作为扩大癌症教育渠道的一部分 现在由九个项目组成，NSIP实习生通过联合论坛受益于近距离对等网络 为他们的教育和职业道路决策提供信息并产生影响。将创新的新模块与 在下一个资助期建立的NSIP组成部分将满足研究、教育、培训和劳动力 癌症研究教育资助计划的发展目标是国家癌症研究所使命的组成部分。