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"Cortical control of facial expression production"

“皮质控制面部表情的产生”

基本信息

批准号：
10614635
负责人：
Geena Ianni
金额：
$ 5.27万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-04 至 2024-05-03
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10614635
关键词：
Affective Anatomy Area Behavior Behavioral Biological Models Body part Brain Brain region Categories Cells Characteristics Clinical Code Communication Complex Data Disease Dissociation Doctor of Philosophy Electrodes Emotional Emotions Expressed Emotion Face Facial Expression Facial Expression Perception Facial Muscles Facial nerve nucleus Fellowship Food Functional Magnetic Resonance Imaging Goals Human Lateral Life Macaca Maps Measures Medial Mental disorders Methodology Methods Monitor Monkeys Mood Disorders Motivation Motor Motor Neurons Movement Muscle National Institute of Mental Health Neuroanatomy Neurons Neuropsychology Neurosciences Outcome Physicians Population Primates Production Property Public Health Research Resolution Schizophrenia Scientist Signal Transduction Social Controls Social Environment Social Network Social Well-Being Societies Specificity Stereotyping Stimulus System Testing Time Training Universities Update Vocabulary Well in self With laterality Work autism spectrum disorder base career human data innovation medical schools microstimulation neural neural circuit neural model neuromechanism neurophysiology neuropsychiatric disorder novel peer programs receptive field showing emotion skills social social communication spatiotemporal

项目摘要

Updated Project Summary: There is a fundamental gap in understanding how the brain produces social communication signals. Facial expressions are a vital social signal in societies, communicating internal affective state and valence of external stimuli. The continued existence of this gap is an important problem because until it is filled, it will be impossible to understand the neural principles that allow us to express emotions, exchange social information, and communicate with peers. Past work has been critically limited to properties of few cells in a single brain region. The recent discovery of the functional network for social communication signal production, when paired with multichannel electrode arrays, allows for simultaneous recordings from populations of cells which compose this distributed network. The long-term goal is to understand how the brain produces socially communicative acts. The overall objective is to elucidate how neural populations in discrete cortical areas control socially communicative facial movements. The central hypothesis is communicative facial movements are controlled by the coordinated activity of a set of functionally specific cortical regions, each containing cells with characteristic spatiotemporal receptive fields. The rationale is this proposal will determine the mechanisms of facial expression production from the level of single cells to cortical territories, enabling mechanistic study of socioemotional expression and its deficit. The hypothesis will be tested by pursuing three specific aims: 1) determine single-cell contributions to facial movement in different nodes of facial expression production network, 2) determine the functional specificity of different nodes of the facial expression production network, and 3) determine whether or not facial expressions result from discrete cortical states. Under the first and third aims, multichannel electrode arrays targeted to fMRI-localized regions will measure the simultaneous activity of neurons across multiple regions of the facial expression production network during socially communicative behavior. In Aim 2, the applicant will use these arrays to deliver intracortical microstimulation in order to causally determine each region’s functional specificity. The proposed research is innovative as it combines two cutting-edge neurophysiological methods in a novel model system of social communication to generate the first mechanistic descriptions of the cortical control of facial expressions. This research is significant because it 1) produces a mechanistic understanding from the level of single cells to a cortical network, of how the brain produces social communication signals through the face, and 2) forms a new model system in which hypotheses related to socioemotional expression and its deficit can be rigorously tested. The applicant’s career goal is to be an academic physician-scientist with a research program aimed at bringing the theoretical motivations and methodologies of systems neuroscience to bear on complex behaviors, in both healthy and disease states. She is pursuing MD-PhD training at Weill Cornell Medical College and The Rockefeller University, and will develop research, scientific communication, and clinical expertise skills during this fellowship.

更新后的项目总结：