Neuropathology Core
神经病理学核心
基本信息
- 批准号:10614010
- 负责人:
- 金额:$ 27.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-01 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AddressAlzheimer&aposs DiseaseArtificial IntelligenceAttentionAutopsyBiological MarkersBiological Specimen BanksBody FluidsBrainBrain regionClassificationClinicalCollaborationsCommunitiesDataDementiaDiagnosticEducationEtiologyEvaluationExpert SystemsFormulationFrontotemporal Lobar DegenerationsFutureGeneticGoalsHumanLaboratoriesLesionMedical centerNational Institute on Alcohol Abuse and AlcoholismNerve DegenerationNeurobiologyNeurosciencesPhenotypePositioning AttributePreparationProcessRecommendationReportingResearchResearch PersonnelResearch Project GrantsResearch SupportResource AllocationSamplingSpecimenTauopathiesTissuesTranslational ResearchTranslationsUnited States Department of Veterans Affairsage relatedbiobankbrain researchbrain tissuechronic traumatic encephalopathydata managementdiagnostic platformexosomeinduced pluripotent stem cellmedical schoolsmicrobiomemultiple omicsneuropathologypreservationtraining opportunity
项目摘要
Mount Sinai ADRC (Sano): Neuropathology Core (Core D) – Research Summary
The overarching aim of the Neuropathology core is to promote research in AD by providing exceptionally well
characterized postmortem human brain tissue and related specimens to ADRC and non-ADRC researchers
within and outside the Mount Sinai neuroscience community and to support the ADRC cores, including the
Clinical, Biomarker, Genetics, Education and Data Management cores. The Core's enduring goal and practice
of providing accurate assessments and well-characterized brain tissues and derivatives to the neuroscience
community is precisely aligned with the National Plan to Address Alzheimer's Disease. Emerging and potentially
paradigm-shifting neuropathological concepts, such as AD subtypes, depend on the availability of well-
characterized brains from extensively phenotyped donors for research. Yet, there is an alarming shortage of well
annotated specimens and neuropathologists with expertise to support the research community. The overall aim
of this core is to continue to maintain and operate the Brain Bank in such a way as to meet the dementia research
needs of neuroscience laboratories optimally while providing state-of the art neuropathologic characterization of
all brain specimens referred to the bank by the clinical core. In addition, Core D endeavors to anticipate the
research needs of the future by banking multiple non-CNS specimens to enable: a) the translation of findings in
the CNS to readily accessible biomarkers; and b) studies of systemic and environmental influences on dementia
neuropathology. The specific aims of the Brain Bank/Neuropathology Core are to: maintain, manage and expand
a large dementia brain biorepository; enable and facilitate state-of-the-art translational research; determine and
record quantitatively the extent and distribution of relevant lesions present within each brain specimen; provide
training opportunities for new core leaders and neuropathology researchers.
西奈山ADRC(SANO):神经病理学核心(D核心)--研究综述
神经病理学核心的首要目标是通过提供特别好的
向ADRC和非ADRC研究人员描述死后人脑组织和相关标本
在西奈山神经科学界内外,并支持ADRC的核心,包括
临床、生物标记、遗传学、教育和数据管理核心。核心的永恒目标和实践
为神经科学提供准确的评估和良好的脑组织及其衍生品
社区与应对阿尔茨海默氏症的国家计划完全一致。新兴的和潜在的
改变范式的神经病理概念,如AD亚型,依赖于良好-
表征来自广泛表型捐赠者的大脑,用于研究。然而,油井短缺令人担忧。
带注释的标本和具有支持研究社区的专业知识的神经病理学家。总体目标
其中的核心是继续维护和运营脑库,以满足痴呆症研究的需要
最大限度地满足神经科学实验室的需求,同时提供最先进的
所有的脑组织标本都由临床核心提交给了银行。此外,Core D努力预测
通过储存多个非中枢神经系统标本来满足未来的研究需要,以实现:a)将研究结果翻译成
中枢神经系统到容易获得的生物标志物;以及b)系统和环境对痴呆症影响的研究
神经病理学。脑库/神经病理核心的具体目标是:维护、管理和扩展
大型痴呆症脑生物信息库;支持和促进最先进的翻译研究;确定和
定量记录每个脑组织标本中存在的相关病变的范围和分布;提供
为新的核心领导者和神经病理学研究人员提供培训机会。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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VAHRAM HAROUTUNIAN其他文献
VAHRAM HAROUTUNIAN的其他文献
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{{ truncateString('VAHRAM HAROUTUNIAN', 18)}}的其他基金
NIH BRAIN AND TISSUE RESPOSITORY (NBTR)
美国国立卫生研究院 (NIH) 脑和组织存储库 (NBTR)
- 批准号:
10916989 - 财政年份:2023
- 资助金额:
$ 27.53万 - 项目类别:
The adaptive-innate immune interactome across multiple tissues in Alzheimer's disease
阿尔茨海默病跨多个组织的适应性先天免疫相互作用组
- 批准号:
10662733 - 财政年份:2023
- 资助金额:
$ 27.53万 - 项目类别:
Single-nucleus transcriptome profiling across multiple brain regions in Parkinson's Disease
帕金森病多个脑区的单核转录组分析
- 批准号:
10372330 - 财政年份:2021
- 资助金额:
$ 27.53万 - 项目类别:
Elevated FSH - A Driver for Sex Differences in Alzheimer's Disease
FSH 升高——阿尔茨海默病性别差异的驱动因素
- 批准号:
10302046 - 财政年份:2021
- 资助金额:
$ 27.53万 - 项目类别:
Elevated FSH - A Driver for Sex Differences in Alzheimer's Disease
FSH 升高——阿尔茨海默病性别差异的驱动因素
- 批准号:
10685326 - 财政年份:2021
- 资助金额:
$ 27.53万 - 项目类别:
Elevated FSH - A Driver for Sex Differences in Alzheimer's Disease
FSH 升高——阿尔茨海默病性别差异的驱动因素
- 批准号:
10495197 - 财政年份:2021
- 资助金额:
$ 27.53万 - 项目类别:
THE PURPOSE OF THIS CONTRACT IS TO ESTABLISH COLLECTION SITES(S) (I.E., THE NIH BRAIN AND TISSUE REPOSITORY (NBTR)) TO PROVIDE SERVICES THAT WILL ACTIVELY ACQUIRE, RECEIVE, PROCESS, STORE, CURATE, PRE
本合同的目的是建立收集站点(即 NIH 大脑和组织存储库 (NBTR)),以提供积极获取、接收、处理、存储、整理、预检的服务
- 批准号:
10473437 - 财政年份:2020
- 资助金额:
$ 27.53万 - 项目类别:
Understanding the protective and neuroinflammatory role of human brain immune cells in Alzheimer Disease
了解人脑免疫细胞在阿尔茨海默病中的保护和神经炎症作用
- 批准号:
10412322 - 财政年份:2020
- 资助金额:
$ 27.53万 - 项目类别:
THE PURPOSE OF THIS CONTRACT IS TO ESTABLISH COLLECTION SITES(S) (I.E., THE NIH BRAIN AND TISSUE REPOSITORY (NBTR)) TO PROVIDE SERVICES THAT WILL ACTIVELY ACQUIRE, RECEIVE, PROCESS, STORE, CURATE, PRE
本合同的目的是建立收集站点(即 NIH 大脑和组织存储库 (NBTR)),以提供积极获取、接收、处理、存储、整理、预检的服务
- 批准号:
10685914 - 财政年份:2020
- 资助金额:
$ 27.53万 - 项目类别:
Understanding the protective and neuroinflammatory role of human brain immune cells in Alzheimer Disease
了解人脑免疫细胞在阿尔茨海默病中的保护和神经炎症作用
- 批准号:
10643264 - 财政年份:2020
- 资助金额:
$ 27.53万 - 项目类别: