Neuropathology Core

神经病理学核心

• 批准号: 10614010
• 负责人: VAHRAM HAROUTUNIAN
• 金额: $ 27.53万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10614010
• 关键词: Address; Alzheimer' s Disease; Artificial Intelligence; Attention; Autopsy; Biological Markers; Biological Specimen Banks; Body Fluids; Brain; Brain region; Classification; Clinical; Collaborations; Communities; Data; Dementia; Diagnostic; Education; Etiology; Evaluation; Expert Systems; Formulation; Frontotemporal Lobar Degenerations; Future; Genetic; Goals; Human; Laboratories; Lesion; Medical center; National Institute on Alcohol Abuse and Alcoholism; Nerve Degeneration; Neurobiology; Neurosciences; Phenotype; Positioning Attribute; Preparation; Process; Recommendation; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resource Allocation; Sampling; Specimen; Tauopathies; Tissues; Translational Research; Translations; United States Department of Veterans Affairs; age related; biobank; brain research; brain tissue; chronic traumatic encephalopathy; data management; diagnostic platform; exosome; induced pluripotent stem cell; medical schools; microbiome; multiple omics; neuropathology; preservation; training opportunity

Mount Sinai ADRC (Sano): Neuropathology Core (Core D) – Research Summary The overarching aim of the Neuropathology core is to promote research in AD by providing exceptionally well characterized postmortem human brain tissue and related specimens to ADRC and non-ADRC researchers within and outside the Mount Sinai neuroscience community and to support the ADRC cores, including the Clinical, Biomarker, Genetics, Education and Data Management cores. The Core's enduring goal and practice of providing accurate assessments and well-characterized brain tissues and derivatives to the neuroscience community is precisely aligned with the National Plan to Address Alzheimer's Disease. Emerging and potentially paradigm-shifting neuropathological concepts, such as AD subtypes, depend on the availability of well- characterized brains from extensively phenotyped donors for research. Yet, there is an alarming shortage of well annotated specimens and neuropathologists with expertise to support the research community. The overall aim of this core is to continue to maintain and operate the Brain Bank in such a way as to meet the dementia research needs of neuroscience laboratories optimally while providing state-of the art neuropathologic characterization of all brain specimens referred to the bank by the clinical core. In addition, Core D endeavors to anticipate the research needs of the future by banking multiple non-CNS specimens to enable: a) the translation of findings in the CNS to readily accessible biomarkers; and b) studies of systemic and environmental influences on dementia neuropathology. The specific aims of the Brain Bank/Neuropathology Core are to: maintain, manage and expand a large dementia brain biorepository; enable and facilitate state-of-the-art translational research; determine and record quantitatively the extent and distribution of relevant lesions present within each brain specimen; provide training opportunities for new core leaders and neuropathology researchers.

西奈山 ADRC（萨诺）：神经病理学核心（核心 D）——研究摘要 神经病理学核心的总体目标是通过提供非常好的信息来促进 AD 研究 向 ADRC 和非 ADRC 研究人员描述死后人类脑组织和相关标本 西奈山神经科学界内外并支持 ADRC 核心，包括 临床、生物标记、遗传学、教育和数据管理核心。核心的持久目标和实践 为神经科学提供准确的评估和良好表征的脑组织和衍生物 社区与解决阿尔茨海默病国家计划完全一致。新兴的和潜在的 范式转变的神经病理学概念，例如 AD 亚型，取决于良好的可用性 对来自广泛表型捐赠者的大脑进行了表征以供研究。然而，井的短缺却令人担忧 带注释的标本和具有专业知识的神经病理学家来支持研究界。总体目标 这一核心的核心是继续维护和运营脑库，以满足痴呆症研究的需要 满足神经科学实验室的最佳需求，同时提供最先进的神经病理学表征 所有脑标本均由临床核心转交给银行。此外，Core D 努力预测 通过存储多个非中枢神经系统标本来满足未来的研究需求，以便：a）将研究结果转化为 中枢神经系统易于获取的生物标志物； b) 系统和环境对痴呆症影响的研究 神经病理学。脑库/神经病理学核心的具体目标是：维护、管理和扩展 大型痴呆症脑生物储存库；实现并促进最先进的转化研究；确定和 定量记录每个大脑样本中存在的相关病变的范围和分布；提供 为新的核心领导者和神经病理学研究人员提供培训机会。