Training in Clinical and Epidemiological Research for Liberia (TRACER)

利比里亚临床和流行病学研究(示踪剂)培训 (2018 Fogarty D43全球传染病研究培训助学金申请) 摘要 加州大学旧金山分校(UCSF)，与国家公众合作 利比里亚卫生研究所(NPHIL)、利比里亚大学和NIH/VERVIL提出了一个 研究培训计划为利比里亚有抱负的年轻研究人员提供全面的 临床和/或流行病学研究目标的授课、指导和经验性培训 急性发热病(AFI)、新发传染病(EID)/埃博拉和疟疾的病原学。 我们的总体目标是培养一支训练有素的调查人员队伍，他们可以成为 该地区可持续、独立的临床/流行病学研究和培训企业。 2014-2016年的埃博拉疫情突显出严重缺乏医疗基础设施和 该国的人力资源；利比里亚是世界第八个最贫穷的国家。我们的特定 根据我们在利比里亚的经验，目标是该国主要的公共卫生传染病 优先事项和由D71资助的需求评估的结果是：1)培训选定的利比里亚人 在临床/流行病学研究中录取他们进入加州大学旧金山分校临床硕士 流行病学和转化学研究(MCR)(N=2)和博士项目(N=1)； 2)支持毕业实习生在利比里亚从事研究工作并开始教学 其他；3)促进对埃博拉、急性发热性疾病和疟疾的研究，并取得进展 加州大学旧金山分校-利比里亚合作研究；4)支持和培训更先进的利比里亚人 调查人员成为有效的导师，并撰写拨款申请。MCR计划 在过去的20年里，成功地培养了年轻调查人员的技能，包括受训人员 来自中低收入国家，其中近90%的人已经成功地 从事研究工作。MCR和PHD课程都侧重于提供基础和 在研究性研究设计和实施、生物统计学、分析、 流行病学，以及研究成果的出版和发表。我们的经验证明 这一成功需要密集的指导和支持性的国内环境 学员回国后的研究机会。加州大学旧金山分校有很强的疟疾和宰牲节 支持学员的研究社区，并正在使用尖端的元基因组测序 确定AFI原因的技术。我们还将利用现有的研究成果 在利比里亚，NIH/NIH的环境和基础设施占了上风，在NPHIL也是如此。我们的共同愿景是 利比里亚最终制定具有国际竞争力的高质量培训方案 在临床研究中。

Training in Clinical and Epidemiological Research (TRACER) in Liberia (2018 Fogarty D43 Global Infectious Disease Research Training Grant Application) ABSTRACT The University of California, San Francisco (UCSF), in collaboration with the National Public Health Institute of Liberia (NPHIL), the University of Liberia, and NIH/PREVAIL, proposes a research training program to provide aspiring young investigators in Liberia with comprehensive didactic, mentored, and experiential training in clinical and/or epidemiological research targeting the etiology of acute febrile illness (AFI), emerging infectious diseases (EID)/Ebola and malaria. Our overall goal is to develop a cadre of well-trained investigators who can become part of a sustainable, independent clinical/ epidemiological research and training enterprise in the region. The 2014-2016 Ebola epidemic highlighted the severe lack of health care infrastructure and human resources in the country; Liberia is the 8th poorest country in the world. Our specific aims, based on our experience in Liberia, the country’s main public health infectious disease priorities, and the results of a D71-funded needs assessment, are to: 1)Train selected Liberians in clinical/epidemiological research by enrolling them into the UCSF Master’s in Clinical Research (MCR) (N=2) and the PhD program in Epidemiology and Translational Science (N=1); 2) Support graduated trainees to pursue their research careers in Liberia, and to begin teaching others; 3) Promote research on EID/Ebola, acute febrile illness, and malaria, and advance UCSF-Liberian collaborative research; 4) Support and train more advanced Liberian investigators to become effective mentors, and to write grant applications. The MCR program has successfully developed skills of young investigators for the last 20 years, including trainees from lower and middle income countries, nearly 90% of whom have gone onto successful research careers. Both the MCR and PhD programs focus on providing fundamental and advanced skills in research study design and implementation, biostatistics, analysis, epidemiology, and publication and presentation of research. Our experience has demonstrated that success requires intensive mentorship and a supportive in-country environment with research opportunities when trainees return home. UCSF has a strong malaria and EID research community to support trainees and is using cutting-edge metagenomics sequencing technology to determine causes of AFI. We will also make use of the existing research environment and infrastructure at NIH/PREVAIL in Liberia, and at NPHIL. Our shared vision is for Liberia to ultimately develop its own internationally competitive high-quality training program in clinical research.