Training in Clinical and Epidemiological Research for Liberia (TRACER)

利比里亚临床和流行病学研究培训（TRACER）

• 批准号: 10614458
• 负责人: JEFFREY N MARTIN
• 金额: $ 24.42万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-10 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10614458
• 关键词: Acute; Applications Grants; Biometry; California; Clinical; Clinical Research; Collaborations; Communicable Diseases; Communities; Country; Doctor of Philosophy; Ebola; Educational process of instructing; Emerging Communicable Diseases; Enrollment; Environment; Epidemic; Epidemiology; Etiology; Fever; Funding; Goals; Healthcare; Home; Human Resources; Infectious Diseases Research; Infrastructure; International; Liberia; Liberian; Malaria; Mentors; Mentorship; Needs Assessment; Public Health; Publications; Research; Research Design; Research Personnel; Research Training; San Francisco; Targeted Research; Technology; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Vision; Writing; career; epidemiology study; experience; investigator training; low and middle-income countries; metagenomic sequencing; programs; research study; skills; success

Training in Clinical and Epidemiological Research (TRACER) in Liberia (2018 Fogarty D43 Global Infectious Disease Research Training Grant Application) ABSTRACT The University of California, San Francisco (UCSF), in collaboration with the National Public Health Institute of Liberia (NPHIL), the University of Liberia, and NIH/PREVAIL, proposes a research training program to provide aspiring young investigators in Liberia with comprehensive didactic, mentored, and experiential training in clinical and/or epidemiological research targeting the etiology of acute febrile illness (AFI), emerging infectious diseases (EID)/Ebola and malaria. Our overall goal is to develop a cadre of well-trained investigators who can become part of a sustainable, independent clinical/ epidemiological research and training enterprise in the region. The 2014-2016 Ebola epidemic highlighted the severe lack of health care infrastructure and human resources in the country; Liberia is the 8th poorest country in the world. Our specific aims, based on our experience in Liberia, the country’s main public health infectious disease priorities, and the results of a D71-funded needs assessment, are to: 1)Train selected Liberians in clinical/epidemiological research by enrolling them into the UCSF Master’s in Clinical Research (MCR) (N=2) and the PhD program in Epidemiology and Translational Science (N=1); 2) Support graduated trainees to pursue their research careers in Liberia, and to begin teaching others; 3) Promote research on EID/Ebola, acute febrile illness, and malaria, and advance UCSF-Liberian collaborative research; 4) Support and train more advanced Liberian investigators to become effective mentors, and to write grant applications. The MCR program has successfully developed skills of young investigators for the last 20 years, including trainees from lower and middle income countries, nearly 90% of whom have gone onto successful research careers. Both the MCR and PhD programs focus on providing fundamental and advanced skills in research study design and implementation, biostatistics, analysis, epidemiology, and publication and presentation of research. Our experience has demonstrated that success requires intensive mentorship and a supportive in-country environment with research opportunities when trainees return home. UCSF has a strong malaria and EID research community to support trainees and is using cutting-edge metagenomics sequencing technology to determine causes of AFI. We will also make use of the existing research environment and infrastructure at NIH/PREVAIL in Liberia, and at NPHIL. Our shared vision is for Liberia to ultimately develop its own internationally competitive high-quality training program in clinical research.

利比里亚临床和流行病学研究培训 (2018 Fogarty D43全球传染病研究培训补助金申请） 摘要 加州大学旧金山分校弗朗西斯科（UCSF）与国家公共 利比里亚卫生研究所（NPHIL），利比里亚大学和NIH/PREVAIL，提出了一个 研究培训计划，为利比里亚有抱负的年轻研究人员提供全面的 针对临床和/或流行病学研究的教学、指导和体验式培训 急性发热性疾病（AFI）、新发传染病（EID）/埃博拉和疟疾的病因。 我们的总体目标是培养一支训练有素的调查人员队伍， 在该区域开展可持续、独立的临床/流行病学研究和培训活动。 2014-2016年的埃博拉疫情凸显了医疗基础设施的严重缺乏， 利比里亚是世界上第八个最贫穷的国家。我们的具体 根据我们在利比里亚的经验， 优先事项和D 71资助的需求评估结果是：1）培训选定的利比里亚人 在临床/流行病学研究通过招收他们进入加州大学旧金山分校硕士临床 研究（MCR）（N=2）和流行病学和转化科学博士课程（N=1）; 2)支持毕业学员在利比里亚从事研究工作，并开始教学 3）促进对EID/埃博拉病毒、急性发热性疾病和疟疾的研究， UCSF-利比里亚合作研究; 4）支持和培训更先进的利比里亚人 研究人员成为有效的导师，并写补助金申请。MCR计划 在过去的20年里，成功地培养了年轻调查员的技能，包括受训人员。 来自低收入和中等收入国家，其中近90%的人已经成功地 研究生涯。MCR和博士课程都侧重于提供基础和 在研究设计和实施，生物统计，分析， 流行病学，以及研究的出版和介绍。我们的经验表明， 这一成功需要密集的指导和支持性的国内环境， 研究机会，当学员返回家园。加州大学旧金山分校有很强的疟疾和EID 研究社区，以支持学员，并正在使用尖端的宏基因组测序 确定AFI原因的技术。我们还将利用现有的研究 利比里亚NIH/PREVAIL和NPHIL的环境和基础设施。我们的共同愿景是 利比里亚最终发展自己具有国际竞争力的高质量培训计划 在临床研究中。