1/2 Predictors and Course of Postpartum Obsessions and Compulsions

1/2 产后强迫症的预测因素和过程

• 批准号: 10614541
• 负责人: Jonathan S. Abramowitz
• 金额: $ 22.02万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10614541
• 关键词: Adverse effects; Allopregnanolone; Anxiety; Attitude; Belief; Biological; Biological Factors; Biological Markers; Biological Phenomena; Budgets; CSF3 gene; Characteristics; Child; Child Rearing; Childbirth; Childhood; Clinical; Clinical Research; Clinical Trials; Data Analyses; Data Analytics; Development; Disease susceptibility; Empirical Research; Ensure; Estradiol; Frequencies; Fright; Future; Granulocyte-Macrophage Colony-Stimulating Factor; IL8 gene; Individual; Infant; Infant Health; Inflammatory; Infrastructure; Interleukin-15; Interleukin-6; Life; Life Stress; Link; Locales; Long-Term Effects; Maternal Health; Mediator; Mental Depression; Mental Health; Mental disorders; Mothers; Nature; Negative Valence; Newborn Infant; North Carolina; Obsession; Outcome; Patient Self-Report; Perinatal; Personal Satisfaction; Phenotype; Physiology; Postpartum Period; Pregnancy; Prevention; Prevention program; Progesterone; Prospective Studies; Psychological Factors; Public Health; Research; Research Domain Criteria; Research Personnel; Risk; Risk Factors; Risk Reduction; Ritual compulsion; Role; Rural; Sampling; Severities; Site; Symptoms; TNF gene; Time; Training; United States National Institutes of Health; Universities; Woman; Work; adverse outcome; antenatal; anxious; chemokine; compulsion; cytokine; data management; depressive symptoms; evidence base; experience; improved; interest; maternal stress; middle childhood; multidisciplinary; obstetric outcomes; perinatal period; peripartum depression; postnatal; prenatal; prospective; psychologic; psychosocial; recruit; response; screening program; treatment program; unborn child

Project Summary/Abstract Obsessional anxiety and compulsive rituals arising during pregnancy and the postpartum have a significant detrimental short-term impact on the well-being of the mother, the pregnancy, the unborn child, and the newborn infant. They also can have negative long-term effects on maternal and infant health, as well as on the mother- infant relationship and on into childhood. Although research has focused on perinatal depressive and anxious states, there is now strong evidence that obsessions and compulsions (OCS) are precipitated or exacerbated by pregnancy and childbirth and may have a deleterious impact on mother and infant. Despite an increased risk of developing OCS during pregnancy and postnatally (i.e., the perinatal period), there is almost no empirical research on its predictors and precursors, how it is related to other postpartum negative valence states such as anxiety and depression, or the specific impact of postpartum OCS on the mother. Accordingly, we will prospectively examine the predictive utility of psychological and biological phenomena (e.g., self-report, physiology) empirically linked to perinatal/postpartum OCS (pOCS), anxiety, and depression, and how these states relate with one another. We also aim to evaluate the extent to which pOCS manifest adverse effects on functionally-related outcomes of significant public health concern, such as obstetric outcomes, maternal health, maternal attitudes, and parenting behaviors during the first year of life. Consistent with the Research Domain Criteria (RDoC) framework, women will be screened antenatally for diatheses empirically demonstrated to predispose to the development or exacerbation of pOCS; and that are thus hypothesized to also put one at risk for pOCS. High- and low-risk groups will be followed during pregnancy and for 6 months postpartum, and repeatedly assessed to identify those experiencing more frequent, intense, and prolonged pOCS and the variables associated with such problems. The two recruitment sites for this study are the University of North Carolina (UNC) at Chapel Hill and Johns Hopkins University (JHU). JHU will provide data management and analytic support. Considering estimates of the high rates of pOCS, together with the limited available information on this subject, the results of this study will help clinicians and researchers 1) use psychological and biological markers elucidated in the current study to identify women at increased risk of developing OCD and its adverse consequences, and 2) reduce the risk of developing OC symptoms in pregnancy, and its adverse consequences, by modifying these psychological and biological factors prior to pregnancy, and in the early prenatal period. Moreover, the risk factors elucidated in this study may be applicable to development of non-pregnancy-related OC symptoms.

项目概要/摘要 怀孕期间和产后出现的强迫性焦虑和强迫性仪式对女性有显着影响。 对母亲、怀孕、未出生的孩子和新生儿的健康产生不利的短期影响 婴儿。它们还可能对孕产妇和婴儿健康以及母亲产生长期负面影响。 婴儿关系一直延续到童年。尽管研究主要集中在围产期抑郁和焦虑 状态，现在有强有力的证据表明强迫观念和强迫症（OCS）是由 怀孕和分娩可能对母亲和婴儿产生有害影响。尽管风险增加 在怀孕期间和产后（即围产期）发展OCS，几乎没有经验 对其预测因子和前体的研究，以及它与其他产后负价态的关系，例如 焦虑和抑郁，或产后 OCS 对母亲的具体影响。据此，我们将 前瞻性地研究心理和生物现象的预测效用（例如，自我报告、 生理学）根据经验与围产期/产后 OCS (pOCS)、焦虑和抑郁相关，以及这些如何 各国之间相互联系。我们还旨在评估 pOCS 对以下方面产生不利影响的程度： 重大公共卫生问题的功能相关结果，例如产科结果、孕产妇健康、 出生第一年的母亲态度和养育行为。与研究领域一致 标准（RDoC）框架，将对女性进行产前筛查，以根据经验证明其素质 容易发生或恶化 pOCS；因此假设这也会使人处于危险之中 对于 pOCS。高风险组和低风险组将在怀孕期间和产后 6 个月内进行随访，并且 反复评估以确定那些经历更频繁、更强烈和更长时间的 POCS 的人，以及 与此类问题相关的变量。本研究的两个招聘地点是北方大学 卡罗莱纳州 (UNC) 教堂山分校和约翰·霍普金斯大学 (JHU)。 JHU 将提供数据管理和 分析支持。考虑到对 pOCS 高发生率的估计以及有限的可用信息 关于这个主题，本研究的结果将帮助临床医生和研究人员1）利用心理和生物 当前研究中阐明的标记物可识别罹患强迫症及其不利风险增加的女性 后果，以及 2) 降低怀孕期间出现 OC 症状的风险及其不良后果， 通过在怀孕前和产前早期改变这些心理和生物因素。 此外，本研究阐明的危险因素可能适用于非妊娠相关的疾病的发展 OC 症状。

项目成果

Co-occurring depression and obsessive-compulsive disorder: A dimensional network approach.

共存的抑郁症和强迫症：维度网络方法。

• DOI: 10.1016/j.jad.2022.08.101
• 发表时间: 2022
• 期刊: Journal of affective disorders
• 影响因子: 6.6
• 作者: Hellberg,SamanthaN;Abramowitz,JonathanS;Ojalehto,HeidiJ;Butcher,MeganW;Buchholz,JenniferL;Riemann,BradleyC
• 通讯作者: Riemann,BradleyC

The contribution of guilt sensitivity in the prediction of obsessive-compulsive disorder symptom dimensions: Replication and extension.

内疚敏感性在强迫症症状维度预测中的贡献：复制和延伸。

• DOI: 10.1016/j.janxdis.2023.102728
• 发表时间: 2023
• 期刊: Journal of anxiety disorders
• 影响因子: 10.3
• 作者: Hellberg,SamanthaN;DuBois,Chase;Myers,NicholasS;Rodriguez,Carly;Butcher,Megan;Ojalehto,HeidiJ;Riemann,Bradley;Abramowitz,JonathanS
• 通讯作者: Abramowitz,JonathanS