Circuit dynamics of structuring episodic memories in humans

构建人类情景记忆的电路动力学

基本信息

  • 批准号:
    10590796
  • 负责人:
  • 金额:
    $ 11.89万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-21 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Project summary Our lives unfold over time, weaving rich, dynamic, and multisensory information into a continuous experience. However, we remember this as a series of discrete events. For example, the memory of a two-hour movie consists of a few memorable moments tied to the main story. During encoding, we segment deviant events and associate relevant events. During retrieval, we utilize the temporal association among encoded events to search for specific memory information. The hippocampus (HPC), prefrontal cortex (PFC) and substantia nigra (SN) are thought to support cognitive computations (i.e., conceptual prediction, prediction error detection, temporal association) that are critical for the encoding and retrieval of episodic memory. However, how these three regions work together to facilitate the construction of episodic memory in humans remains unclear. The proposed study aims to address this by identifying neural dynamics in the HPC-PFC-SN network and revealing circuit-level neural mechanisms of event segmentation and its relationship with human episodic memory. The central hypothesis is that event segmentation, which is influential in episodic memory formation and retrieval, emerges from the difference between the HPC perceptual predictions and received sensory inputs, which is tracked by dopaminergic neurons in the SN to update event models stored in the PFC. To test this, I will record both single neuron activity and local field potential signals in the HPC-PFC-SN network while patients, who have depth electrodes implanted for clinical purposes, encode, and retrieve the memory of semi-realistic experience created by well-controlled video clips. I will also build a computational model that can rigorously reproduce the observed behavioral and neural signatures. The trained model will be used as a proxy of the HPC-PFC-SN network to study the causal link between this tripartite network and memory behaviors by simulating computational “lesions”, which will provide insightful guidance for real electrical stimulation. To achieve the proposed goals, I will pursue training mentored by a group of experts in different fields, including the intraoperative recordings (Dr. Ziv Williams and Dr. Adam Mamelak), analyses of inter-regional neural dynamics and electrical stimulation (Dr. Ueli Rutishauser), and computational modeling (Dr. Gabriel Kreiman). The comprehensive analytic approaches spinning from behavior measurements, invasive neural recordings from both microscopic and mesoscopic levels, computational modeling and electrical stimulation will provide valuable opportunities to strengthen our understanding of human episodic memory system. The expected outcomes of this proposal will potentially advance the development of therapeutic interventions for memory-related disorders.
项目总结

项目成果

期刊论文数量(0)
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会议论文数量(0)
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Jie Zheng其他文献

Jie Zheng的其他文献

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{{ truncateString('Jie Zheng', 18)}}的其他基金

Circuit Dynamics of Structuring Episodic Memories in Humans
构建人类情景记忆的电路动力学
  • 批准号:
    10708113
  • 财政年份:
    2022
  • 资助金额:
    $ 11.89万
  • 项目类别:
Noninvasive Monitoring of Hepatic Glutathione Depletion Through Blood Test
通过血液检测无创监测肝脏谷胱甘肽消耗情况
  • 批准号:
    10230423
  • 财政年份:
    2021
  • 资助金额:
    $ 11.89万
  • 项目类别:
Noninvasive Monitoring of Hepatic Glutathione Depletion Through Blood Test
通过血液检测无创监测肝脏谷胱甘肽消耗情况
  • 批准号:
    10552664
  • 财政年份:
    2021
  • 资助金额:
    $ 11.89万
  • 项目类别:
Noninvasive Monitoring of Hepatic Glutathione Depletion Through Blood Test
通过血液检测无创监测肝脏谷胱甘肽消耗情况
  • 批准号:
    10377423
  • 财政年份:
    2021
  • 资助金额:
    $ 11.89万
  • 项目类别:
Glomerular Filtration of Sub-nm Gold Nanoparticles
亚纳米金纳米颗粒的肾小球滤过
  • 批准号:
    10188515
  • 财政年份:
    2018
  • 资助金额:
    $ 11.89万
  • 项目类别:
Surface chemistry for high-contrast fluorescence kidney imaging
高对比度荧光肾脏成像的表面化学
  • 批准号:
    9110279
  • 财政年份:
    2014
  • 资助金额:
    $ 11.89万
  • 项目类别:
Surface chemistry for high-contrast fluorescence kidney imaging
高对比度荧光肾脏成像的表面化学
  • 批准号:
    8753250
  • 财政年份:
    2014
  • 资助金额:
    $ 11.89万
  • 项目类别:
Surface chemistry for high-contrast fluorescence kidney imaging
高对比度荧光肾脏成像的表面化学
  • 批准号:
    8912470
  • 财政年份:
    2014
  • 资助金额:
    $ 11.89万
  • 项目类别:
Develop a Dual Functional Nanoprobe for Integration of Fluorescence microscopy wi
开发用于集成荧光显微镜的双功能纳米探针
  • 批准号:
    8223169
  • 财政年份:
    2011
  • 资助金额:
    $ 11.89万
  • 项目类别:
Develop a Dual Functional Nanoprobe for Integration of Fluorescence microscopy wi
开发用于集成荧光显微镜的双功能纳米探针
  • 批准号:
    8047401
  • 财政年份:
    2011
  • 资助金额:
    $ 11.89万
  • 项目类别:

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