Dynamic circuit motifs underlying multimodal interactions in primate auditory cortex

灵长类听觉皮层多模态相互作用的动态电路基序

• 批准号: 10586804
• 负责人: Stephan Bickel
• 金额: $ 69.82万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10586804
• 关键词: Action Potentials; Anatomy; Animal Model; Area; Attention; Auditory; Auditory Perception; Auditory area; Auditory system; Automobile Driving; Behavior; Behavioral; Brain; Brain Diseases; Cells; Characteristics; Clinical; Communities; Complex; Computer Models; Coupled; Cues; Data; Data Analyses; Data Collection; Decision Making; Electric Stimulation; Electrical Stimulation of the Brain; Electrodes; Electroencephalography; Electrophysiology (science); Elements; Environment; Epilepsy; Equilibrium; Eye Movements; Fingerprint; Functional disorder; Future; Goals; Hearing; Hearing problem; Human; Implant; Link; Location; Maps; Measures; Methods; Modeling; Motivation; Motor; Movement; Neurons; Neurosciences; Operative Surgical Procedures; Patients; Pattern; Performance; Periodicity; Physiological Processes; Play; Primates; Probability; Process; Property; Rodent; Role; Saccades; Sampling; Sensory; Signal Transduction; Study models; Support System; System; Testing; Thalamic structure; Translating; Translations; Visual attention; Waxes; auditory processing; base; data analysis pipeline; design; experimental study; goal oriented behavior; improved; memory recall; multimodality; multisensory; neuronal circuitry; neurophysiology; neuropsychiatry; neuroregulation; nonhuman primate; operation; predictive modeling; relating to nervous system; response; selective attention; success; ultra high resolution; visual motor; visual stimulus

ABSTRACT There is a strong movement within the neuroscience community towards studying the brain under naturalistic conditions, in rich multisensory paradigms and in the context of behaviors observed in natural environments, such as free viewing. This requires transforming our traditional data collection and analysis pipelines, and their underlying theoretical frameworks. Instead of focusing on one specific system supporting a particular brain function, we must conduct multisite recordings targeting multiple, reciprocally connected circuits, which is the main motivation for our project. Fortunately, this is now technically feasible in both human and nonhuman primates. The overarching goal of our project is to define information transmitting (“driving”) vs. “modulatory” circuits of the auditory system. The rationale for this goal is that if only driving circuits existed in the brain, we would not have the ability to focus on behaviorally relevant aspects of our environment. From this perspective, modulatory circuits play as an important role in brain operations as information transmitting ones. Specifically, our project will explore the interaction of four domains of brain function and the distinctive, dynamic circuit motifs (circuits and their spectrotemporal neuronal activity patterns) that underlie them. These brain functions are auditory perception, multisensory interactions within the auditory system, motor sampling of the environment (eye movements), and memory recall. We will utilize electrophysiological recordings during behavioral experiments in non-human and human primates, with computational modeling to bridge the gap between different recording scales (single unit to EEG), and species (non-human primate vs. human). Computational models will also be used to suggest specific target nodes and patterns of the distinct circuits for neuromodulation. Using the spectrotemporal neuronal activity (a key feature of a dynamic circuit motif) and model prediction based intracranial electrical brain stimulation, we will verify each identified circuit’s causal role in producing its unique circuit motifs and in supporting different aspects of behavior.

摘要