Brain-Behavioral Predictors of Interpersonal Stress Generation and Depression Risk in Adolescent Girls

青春期女孩人际压力产生和抑郁风险的大脑行为预测因素

• 批准号: 10591196
• 负责人: Cope Feurer
• 金额: $ 20.21万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10591196
• 关键词: Adolescence; Adolescent; Adult; Affective; Age; Area; Behavior; Behavioral; Behavioral Mechanisms; Biological; Brain; Chicago; Coupled; Cues; Data; Detection; Development; Down-Regulation; Early Diagnosis; Ecological momentary assessment; Enrollment; Environment; Etiology; Exhibits; Family; Female; Female Adolescents; Functional Magnetic Resonance Imaging; Future; Generations; Goals; Grain; Grant; Illinois; Individual; Intervention; Interview; Life Stress; Link; Major Depressive Disorder; Mediating; Mediator of activation protein; Mental Depression; Mentorship; Methodology; Modeling; Moods; Morbidity - disease rate; National Institute of Mental Health; Neurobiology; Nucleic Acid Regulatory Sequences; Onset of illness; Parents; Patient Self-Report; Peripheral; Prevention; Process; Reactive depression; Recording of previous events; Recurrence; Regulation; Reporting; Research; Risk; Risk Factors; Role; Sampling; Social Interaction; Social Processes; Statistical Methods; Stress; Stressful Event; Suicide; Techniques; Testing; Time; Training; Universities; Variant; Work; Youth; affective neuroscience; brain behavior; career; child depression; depression prevention; depressive symptoms; design; disorder risk; follow-up; girls; imaging study; improved; indexing; multilevel analysis; negative affect; neural correlate; neural patterning; neuroimaging; neuromechanism; novel; peer; prospective; relating to nervous system; response; skill acquisition; skills; social; social exclusion; social stress; stressor; translational scientist

Risk for major depressive disorder (MDD) onset dramatically increases during adolescence, particularly for girls. There is a vital need to elucidate the underlying mechanisms of MDD risk to improve early risk detection and targeted preventions. The stress generation model posits interpersonal stress generation (I-StressGen) as a mechanism of risk and proposes that youth with preexisting MDD vulnerabilities actively contribute to the occurrence of interpersonal stressful life events in their lives (i.e., I-StressGen), which in turn exacerbates their risk for MDD. Although the impact of I-StressGen on prospective MDD risk in adolescents is well-established, the precise mechanisms contributing to I-StressGen remain unclear. Self-report research indicates increased affective reactivity during negative social interactions as a promising mechanism contributing to I-StressGen, though this has not been directly tested. The underlying neural mechanisms of I-StressGen also remain unexamined, despite work suggesting that greater social stress is associated with aberrant activation in corticolimbic regions during tasks probing response to negative social interactions. Therefore, the overarching goal of the proposed study is to obtain a fine-grained, mechanistic understanding of the role of brain and behavioral affective reactivity during negative social interactions as it relates to I-StressGen and subsequent MDD risk in female adolescents. The proposed study will enroll a risk-enhanced sample of 90 female adolescents (ages 13-15) and will utilize neuroimaging (fMRI) and ecological momentary assessment (EMA) to examine brain and behavior indices of socio-affective reactivity as predictors of I-StressGen and depression symptoms across a multi-wave one year follow-up. In doing so, the current study will test whether affective reactivity during negative social interactions at the neural (Aim 1) and real-world behavioral (Aim 2) level prospectively predicts I- StressGen, and whether I-StressGen mediates the relation between this socio-affective reactivity and prospective increases in female adolescents’ depression symptoms (Aim 3). The proposed study and parallel training plan will allow the Candidate to build upon her current expertise in adolescent stress and MDD risk and develop new skills in four key areas: (1) fMRI, (2) EMA, (3) advanced statistical multilevel modeling, and (4) professional development. The rich academic environment at the University of Illinois at Chicago coupled with the collective expertise of the Candidate’s mentorship team in fMRI methodology, developmental affective neuroscience, EMA, and advanced statistical techniques will facilitate successful implementation of the proposed study and training plan. The acquisition of these skills will be integral to launching the Candidate’s independent career as a translational scientist focused on delineating brain-behavioral mechanisms of adolescent MDD risk within the context of real-world interpersonal stress. Results from this study will inform the development of future grants focused on characterizing socio-affective brain and behavior mechanisms and aberrant developmental trajectories contributing to the emergence of maladaptive stress processes and MDD onset in adolescence.

青春期期间，重度抑郁症 (MDD) 发病的风险急剧增加，尤其是女孩。 迫切需要阐明 MDD 风险的潜在机制，以改进早期风险检测和预防 有针对性的预防。压力产生模型将人际压力产生（I-StressGen）视为 风险机制，并建议具有 MDD 脆弱性的青年积极为 生活中发生人际压力生活事件（即 I-StressGen），这反过来又加剧了他们的 MDD 的风险。尽管 I-StressGen 对青少年预期 MDD 风险的影响已得到证实， I-StressGen 的确切机制仍不清楚。自我报告研究表明 消极社交互动期间的情感反应是促进 I-StressGen 的一种有前途的机制， 尽管这尚未经过直接测试。 I-StressGen 的潜在神经机制也仍然存在 尽管有研究表明更大的社会压力与异常激活有关，但未经检验 探索对消极社交互动的反应的任务期间的皮质边缘区域。因此，总体 拟议研究的目标是获得对大脑和 消极社交互动期间的行为情感反应，因为它与 I-StressGen 和随后的相关 女性青少年的 MDD 风险。拟议的研究将招募 90 名女性青少年作为风险增强样本 （13-15 岁）并将利用神经影像学 (fMRI) 和生态瞬时评估 (EMA) 来检查大脑 和社会情感反应的行为指数作为 I-StressGen 和抑郁症状的预测因子 多波一年的后续行动。为此，当前的研究将测试消极期间的情感反应是否 神经（目标 1）和现实世界行为（目标 2）水平的社交互动前瞻性地预测 I- StressGen，以及 I-StressGen 是否介导这种社会情感反应与 女性青少年抑郁症状的预期增加（目标 3）。拟议的研究和并行 培训计划将使候选人能够利用她目前在青少年压力和 MDD 风险方面的专业知识， 开发四个关键领域的新技能：(1) fMRI、(2) EMA、(3) 高级统计多级建模，以及 (4) 专业发展。伊利诺伊大学芝加哥分校丰富的学术环境加上 候选人导师团队在功能磁共振成像方法、发展情感方面的集体专业知识 神经科学、EMA 和先进的统计技术将促进拟议的成功实施 学习和培训计划。获得这些技能对于启动候选人的独立项目至关重要 作为一名转化科学家，专注于描绘青少年 MDD 风险的大脑行为机制 在现实世界的人际压力的背景下。这项研究的结果将为未来的发展提供信息 赠款重点关注社会情感大脑和行为机制以及异常发育的特征 导致青春期适应不良压力过程和抑郁症发作的轨迹。