Emotion processing, gender identity, and differential risk for anxiety and depression in autistic adults

自闭症成人的情绪处理、性别认同以及焦虑和抑郁的差异风险

• 批准号: 10590108
• 负责人: Goldie Ann McQuaid
• 金额: $ 15.89万
• 依托单位: GEORGE MASON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-08 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10590108
• 关键词: Address; Adolescent; Adult; Affect; Age; Alexithymias; Amygdaloid structure; Anxiety; Attenuated; Awareness; Behavioral; Birth; Brain; Brain imaging; Child; Cognitive; Data Set; Development; Development Plans; Down-Regulation; Ecological momentary assessment; Emotional; Emotions; Environment; Exhibits; Face; Female; Functional Magnetic Resonance Imaging; Gender; Gender Identity; General Population; Goals; Health; Individual; Influentials; Intellectual functioning disability; Intervention; Label; Longevity; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mental Depression; Mental Health; Mentors; Mentorship; Methods; Minority; Modeling; Moods; Outcome; Personal Satisfaction; Phenotype; Population; Positioning Attribute; Predictive Factor; Predisposing Factor; Prefrontal Cortex; Prevalence; Protocols documentation; Psyche structure; Research; Research Design; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Role; Sampling; Scientist; Severities; Shapes; Social Behavior; Stress; Suicide; Symptoms; Training; Up-Regulation; Woman; adult with autism spectrum disorder; aged; anxiety symptoms; autism spectrum disorder; base; biomarker identification; bodily sensation; brain magnetic resonance imaging; career; cisgender; cognitive reappraisal; cohesion; comorbid depression; depressive symptoms; emotion dysregulation; emotion regulation; expectation; experience; gender diversity; improved; individuals with autism spectrum disorder; male; multidisciplinary; multilevel analysis; open data; phenomenological models; programs; psychiatric comorbidity; relating to nervous system; severe mental illness; sex; skills; social; social deficits; social expectations; suicidal; trait; young adult

Project Summary/Abstract Research Project Long-Term Objectives: The project will characterize phenotypic & brain factors related to co-occurring depression & anxiety in adults with autism spectrum disorder [ASD] without intellectual disability, with a focus on understudied populations at elevated risk for these conditions: females [ASDf] and gender diverse [ASDgd] individuals. Results will inform biomarker identification for comorbid depression & anxiety in ASD. Overall research design: 3 samples of ASD young adults (aged 18-30y) will be examined. All samples share phenotyping measures; two samples have a common magnetic resonance imaging [MRI] protocol: i) purposively sampled ASDf, ASDgd & ASD males will undergo phenotyping & MRI; ii) ASDf- & ASDgd-enriched sample will undergo phenotyping; iii) existing phenotyping & MRI dataset from a study that oversampled ASDf. Aim 1: Delineate impacts of emotion identification/awareness (alexithymia) & emotion regulation [ER] on depression & anxiety, and roles of sex & a continuous measure of gender identity in these impacts. Methods: multi-level modeling of depressive & anxious symptoms collected via ecological momentary assessment [EMA] will examine alexithymia as a cognitive factor in depression & anxiety, and its association with ER. Aim 2: Delineate brain networks associated with alexithymia & its impacts on depression/anxiety/ER. Methods: regression modeling will relate structural & functional MRI brain connectivity metrics to alexithymia, ER & depression & anxiety. Health Relatedness: ASD adults experience depression & anxiety at elevated rates. Associated with these conditions, ASD adults show alarmingly elevated levels of suicidality. There is no good understanding of why this is, and there is relatively little research on mechanisms—including cognitive and neural factors—that predispose ASD adults to these serious mental health conditions. Candidate’s Career Goals & Development Plan: Dr. McQuaid’s long-term goal is to become an independent investigator with a research program focused on ASD in adulthood and factors relevant to improving mental health in this population. Her short-term goals are to characterize brain & behavioral/cognitive factors that predict increased vulnerability for depression & anxiety among ASDf & ASDgd adults. Building on her multidisciplinary background, Dr. McQuaid will receive training in 1) ASD presentations, gender diversity, & phenomenology & measurement of mood/anxiety in ASD; 2) EMA & computing skills; 3) professional development & open science. Environment: Dr. McQuaid is supported by a cohesive team of expert scientists with overlapping & complementary research programs. They will provide an intensive, focused, & seamless mentorship experience, and their respective expertise & institutional affiliations will provide Dr. McQuaid with the requisite guidance & resources to achieve the research aims & training goals. Taken together, the research & training, mentor team, & environment afforded by the K01 will serve as a bridge that will successfully transition Dr. McQuaid from her current position to that of a fully independent investigator.

项目总结/摘要 研究项目长期目标：该项目将表征与以下相关的表型和大脑因素： 在没有智力残疾的自闭症谱系障碍[ASD]成人中同时发生抑郁和焦虑， 重点关注这些疾病风险升高的未充分研究人群：女性[ASDf]和性别多样性 [ASDgd]个人。结果将为ASD中共病抑郁和焦虑的生物标志物鉴定提供信息。 总体研究设计：将检查3个ASD年轻成人（年龄18- 30岁）样本。所有样品共享 表型测定;两个样品具有共同的磁共振成像[MRI]方案：i）有目的地 采样的ASDf、ASDgd和ASD男性将经历表型分析和MRI; ii）ASDf-和ASDgd富集的样品将 进行表型分析; iii）来自过采样ASDf的研究的现有表型分析和MRI数据集。目标1： 描述情绪识别/意识（述情障碍）和情绪调节[ER]对抑郁症和 焦虑和性别角色&这些影响中性别认同的持续测量。方法：多层次 通过生态瞬时评估（EMA）收集的抑郁和焦虑症状建模将检查 述情障碍作为抑郁症和焦虑症的认知因素及其与ER的关系目标2：描绘大脑 与述情障碍相关的网络及其对抑郁/焦虑/ER的影响方法：回归模型将 将结构和功能MRI大脑连接指标与述情障碍、ER、抑郁和焦虑相关。 健康相关性：ASD成年人经历抑郁和焦虑的比率升高。与这些 在这种情况下，ASD成年人表现出惊人的自杀倾向。没有很好的理解为什么 这是，有相对较少的研究机制，包括认知和神经因素， 使ASD成年人容易患上这些严重的心理健康状况。 候选人的职业目标和发展计划：麦奎德博士的长期目标是成为一名独立的 研究项目的研究人员专注于成年期ASD和与改善心理健康相关的因素 这个人群的健康。她的短期目标是描述大脑和行为/认知因素， ASDf和ASDgd成年人中抑郁和焦虑的脆弱性增加。基于她的多学科 麦奎德博士将接受1）ASD介绍，性别多样性和现象学的培训， ASD的情绪/焦虑测量; 2）EMA和计算技能; 3）专业发展和开放科学。 环境：麦奎德博士由一个有凝聚力的专家科学家团队提供支持， 补充研究计划。他们将提供一个密集的，集中的，无缝的指导经验， 他们各自的专业知识和机构关系将为麦奎德博士提供必要的指导和 资源，以实现研究目标和培训目标。总的来说，研究和培训，导师团队， K 01提供的环境将作为一座桥梁，成功地将麦奎德博士从她的 目前的职位是完全独立的调查员。