Disrupted Spatial and Temporal Nociceptive Filtering in Adolescents with and Risk for Overlapping Pain Conditions
患有重叠疼痛的青少年的空间和时间伤害性过滤被破坏以及存在重叠疼痛的风险
基本信息
- 批准号:10592728
- 负责人:
- 金额:$ 53.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:Abdominal PainAbsence of pain sensationAdolescentAdultAgeAwarenessBackBehavioralChildhoodChronicClinicControl GroupsDevelopmentDimensionsEarly identificationEnrollmentEventFemaleFoundationsFutureGastroenterologyGoalsIndividualIndividual DifferencesKnowledgeLifeLongevityMedical centerMethodsMigraineMusculoskeletalMusculoskeletal PainNeuraxisNeurosciencesNociceptionPainPain ResearchPain managementParticipantPatientsPatternPhenotypePilot ProjectsPositioning AttributePreventionPublic HealthQuality of lifeRecording of previous eventsResearchRheumatologyRiskRisk FactorsSampling StudiesSensorySleep disturbancesStimulusStressTestingTimeUnited States National Institutes of HealthYouthbasebiopsychosocialchronic painchronic painful conditionclinical infrastructureclinically relevantconditioned pain modulationdaily functioningdesigndisabilityexperiencehigh riskinnovationinsightlongitudinal designmultidisciplinarypatient subsetspreventprogramsprospectivepsychosocialrecruitscreeningsexsomatosensory
项目摘要
PROJECT ABSTRACT
While localized primary pain conditions are prevalent in youth, a significant subset of these patients experience
multiple pain conditions and meet the criteria for chronic overlapping pain conditions (COPCs). COPCs have a
marked negative impact on daily functioning and quality of life in youth and carry a high risk for continued pain
and disability into adulthood. The underlying factors contributing to the development and persistence of
COPCs in youth are unknown. The current proposal offers an innovative and previously unexplored approach
to determine whether disruptions in spatial (concurrent noxious stimuli across the body) and temporal (noxious
stimuli presented over time) filtering of nociceptive processing, reflecting pain amplification (e.g., increased
facilitation and/or reduced inhibition), contribute to COPCs. Several quantitative sensory testing methods are
uniquely positioned to probe disruptions in nociceptive filtering across spatial (spatial summation, SS;
conditioned pain modulation, CPM) and temporal (temporal summation, TS; offset analgesia, OFA) domains.
Our recent pilot studies found evidence for greater disruptions in spatial (CPM) and temporal (TS) filtering in
youth with COPCs. Our primary objective is to determine if spatial and temporal filtering of nociceptive
information differentiate youth with COPCs from those with localized pain and healthy controls and determine
whether distinct profiles of disrupted nociceptive processing are associated with the transition of localized pain
to COPCs. To accomplish this, the current study will leverage expertise and a vast clinical infrastructure
(Migraine, Gastroenterology, Rheumatology and Pain Management clinics) at large pediatric medical center to
enroll 140 youth with a localized pain condition (migraine, abdominal pain, local MSK), and 140 youth with
COPC’s. We will also recruit 140 healthy youth to serve as a control group. Following initial phenotyping to
delineate disruptions in spatial and temporal dimensions of nociceptive processing (Aim 1), participants will be
assessed for changes in pain status (localized to COPCs) every three months for one year (Aim 2). In Aim 1,
we hypothesize that youth with COPCs will show disrupted spatial (reflected by reduced CPM and enhanced
SS) and temporal (reflected by enhanced TS and reduced OFA) processing compared to youth with localized
pain and healthy controls. These findings will delineate specific disruptions of nociceptive processing in
patients with COPCs. For Aim 2, we hypothesize that a subset of youth with localized pain and disrupted
spatial and temporal filtering will develop COPCs. We will examine the stability of spatial and temporal filtering
at clinically relevant timepoints (3-, 6-, and 12-months). We will also explore whether the disrupted filtering and
the transition to COPCs are influenced by factors including concomitant treatments. Our research will provide
the first insight into the presence and impact of disrupted nociceptive filtering related to COPCs and its
naturalistic progression from localized pain. This information will be critical in identifying risk patterns that can
be useful in prevention of progression to COPCs and mitigating long-term risk.
项目摘要
项目成果
期刊论文数量(0)
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Christopher D King其他文献
Christopher D King的其他文献
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{{ truncateString('Christopher D King', 18)}}的其他基金
Disrupted Spatial and Temporal Nociceptive Filtering in Adolescents with and Risk for Overlapping Pain Conditions
患有重叠疼痛的青少年的空间和时间伤害性过滤被破坏以及存在重叠疼痛的风险
- 批准号:
10582930 - 财政年份:2023
- 资助金额:
$ 53.66万 - 项目类别:
Physiological correlates of endogenous pain modulation in healthy individuals and
健康个体内源性疼痛调节的生理相关性
- 批准号:
8531209 - 财政年份:2012
- 资助金额:
$ 53.66万 - 项目类别:
Physiological correlates of endogenous pain modulation in healthy individuals and
健康个体内源性疼痛调节的生理相关性
- 批准号:
8300377 - 财政年份:2012
- 资助金额:
$ 53.66万 - 项目类别:














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